专利号:US-9995750-B2 优先权日:2013-12-05 标 题:Methods of detecting and measuring glutamine and analogues thereof, and methods related thereto 发明人:ACKERLEY DAVID FRANCIS; BROWN ALISTAIR SINCLAIR; ROBINS KATHERINE JANE 权利人:VICTORIA LINK LTD 摘要:Method for the detection of glutamine and its analogs are provided by the present disclosure. Also provided are methods for measuring the levels of glutamine and its analogs, including diagnostic methods. Further provided are methods that utilize glutamine analogs for the synthesis of colored pigments and other useful agents. The methods comprise the use of a nonribosomal peptide synthetase (NRPS) under conditions to produce an indigoidine or indigoidine-related pigment.
专利号:US-7163917-B2 优先权日:2002-06-17 标 题:Synthesis method of alanylglutamine 发明人:ZHAO YUFEN; TANG GUO; ZHOU NING; HU LIMING; CHEN YONG 权利人:ZHAO YUFEN; TANG GUO; ZHOU NING; HU LIMING; CHEN YONG 摘要:A synthesis method of alanyl-glutamine includes the steps of: The N-terminal protected alanine reacts with triphenylphosphine and hexachloroethane in organic solvent to form active ester, the active ester reacts with glutamine in a solution mixture containing organic solvent and aqueous solution of inorganic base, the resultant mixture is acidified with inorganic acid, and then the N-terminal protecting group is removed. In this method, the raw materials are cheap, the synthesis technique is simple, no disposals of separation and purification are needed, the product is easy to be separated and purified, the toxicities of all the reagents used in the course of production are minimal, it is advantageous to environment protection.
专利号:US-2024400861-A1 优先权日:2021-10-01 标题 :Triazole- And/Or Triazolium-Based Polymers And Copolymers As Additives For Chemical Mechanical Planarization Slurries 发明人:LARBIG GREGOR; KIRSCH PEER; HENGST MATTHIAS; SHI XIAOBO; STENDER MATTHIAS 权利人:VERSUM MAT US LLC 摘要:Synthesis of triazole- and/or triazolium-based polymers is disclosed. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising triazole- and/or triazolium-based polymers; and water. The use of the synthesized triazole- and/or triazolium-based polymers in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.
专利号:WO-2024073211-A1 优先权日:2022-09-29 标题:Guanidinium-based polyionic liquids and their use as additives for chemical mechanical planarization slurries 发明人:LARBIG GREGOR; KIRSCH PEER; SHI XIAOBO 权利人:VERSUM MAT US LLC 摘要:Synthesis of guanidinium-based polymers is disclosed. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising guanidinium-based polymers; and water. The use of the synthesized guanidinium-based polymers in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.
专利号:US-2025215130-A1 优先权日:2022-04-11 标 题:Polycationic Polymer Or Copolymer Having Different Cation Types For Slurries In Chemical Mechanical Planarization 发明人:LARBIG GREGOR; SHI XIAOBO 权利人:MERCK PATENT GMBH; VERSUM MAT US LLC 摘要:Synthesis of polycationic polymer or copolymer is disclosed. The polycationic polymer or copolymer are formed by at least one first cationic monomer and at least one second cationic monomer wherein the first cationic monomer and the second cationic monomer have different cationic groups; such as imidazolium group and non-imidazolium group. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising polycationic polymer or copolymer; and water are also disclosed. The use of the synthesized polycationic polymer or copolymer in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.
专利号:US-4656249-A 优先权日:1982-06-10 标题 :Peptides with relaxin activity 发明人:TREGEAR GEOFFREY W; DU YU-CANG; NIALL HUGH D 权利人:FLOREY HOWARD INST 摘要:A method for the synthesis of porcine relaxin or modified forms or analogues thereof, which comprises the steps of reducing a mixed solution of the S-sulfonated A and B peptide chains, or modified forms or analogues thereof; precipitating the reduced peptides with acetone; washing the mixed peptides; oxidizing the mixed peptides in the presence of aqueous sodium chloride; and isolating the relaxin thus produced. n Also claimed are modified forms and analogues of porcine relaxin analogues which comprise shortened forms of the natural B and/or A peptide chains, and/or in which one or both of A and B chains in the full length or shortened form has been chemically modified.
1: Fang YC, Wan HT, Yu L, Yin F, Yang JH, Zhou HF, He Y. [Pharmacokinetics of main activ ingredients of Guhong injection in cerebral ischemia rats]. Zhongguo Zhong Yao Za Zhi. 2018 May;43(9):1940-1945. doi: 10.19540/j.cnki.cjcmm.20180206.001. Chinese. doi: 10.3389/fphar.2018.00493. eCollection 2018. 3: Li D, Chen YG, Zhang CJ, Tian J, Li X. Safflower Extract and Aceglutamide Injection Promoting Recovery of Peripheral Innervations via Vascular Endothelial Growth Factor-B Signaling in Diabetic Mice. Chin Med J (Engl). 2017 Dec 5;130(23):2829-2835. doi: 10.4103/0366-6999.219143. 4: Ai J, Wan H, Shu M, Zhou H, Zhao T, Fu W, He Y. Guhong injection protects against focal cerebral ischemia-reperfusion injury via anti-inflammatory effects in rats. Arch Pharm Res. 2017 May;40(5):610-622. doi: 10.1007/s12272-016-0835-4. Epub 2016 Sep 13. doi: 10.3233/RNN-150509. doi: 10.1093/chromsci/bmu123. Epub 2014 Sep 19. doi: 10.1002/humu.21272. Spanish. Japanese.
合成参考文献
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:International Journal of Toxicology 36(Suppl. 1):17-56, 2017 参考文献:10.1016/j.jmb.2004.07.023|10.2210/pdb1xpy/pdb|10.2210/pdb1xs2/pdb 摘要:Wang WC, Chiu WC, Hsu SK, Wu CL, Chen CY, Liu JS, Hsu WH. Structural basis for catalytic racemization and substrate specificity of an N-acylamino acid racemase homologue from Deinococcus radiodurans. J Mol Biol. 2004 Sep 03;342(1):155–69. doi: 10.1016/j.jmb.2004.07.023. 参考文献:10.1159/000079179 摘要:Racine SX, Le Toumelin P, Adnet F, Cohen Y, Cupa M, Hantz E, Le Moyec L. N-acetyl functions and acetate detected by nuclear magnetic resonance spectroscopy of urine to detect renal dysfunction following aminoglycoside and/or glycopeptide antibiotic therapy. Nephron Physiol. 2004;97(4):p53–7. doi: 10.1159/000079179. 参考文献:10.1021/ac051316y 摘要:Schirm M, Schoenhofen IC, Logan SM, Waldron KC, Thibault P. Identification of unusual bacterial glycosylation by tandem mass spectrometry analyses of intact proteins. Anal Chem. 2005 Dec 01;77(23):7774–82. doi: 10.1021/ac051316y.