CAS: 2430-16-2; 6-Phenylhexan-1-Ol

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6-phenyl-hexanoic acid methyl ester ethylmagnesium bromide 1-chloro-3-hydroxypropane 2,3-dichlorotetrahydro-2H-pyran (6-bromohexyl)benzene 6-phenyl-1-hexylchloride 6-Methyl-naphthalene-2-sulfonic acid 6-phenyl-hexyl ester 3-phenyl-propionaldehyde

📜1,5-已二烯置于双氧水,Potassium Hydroxide体系中,用 四氢呋喃,水 用作溶剂,化学反应 5.5H,反应生成苯已醇
参考文献:使用 B-Thexylboracyclanes 通过顺序 Suzuki-Miyaura 偶联合成不对称末端双官能化烷烃
标题:使用 B-Thexylboracyclanes 通过顺序 Suzuki-Miyaura 偶联合成不对称末端双官能化烷烃
摘要:报道了使用 B-Thexylboracyclanes 的一锅顺序 Suzuki-Miyaura 偶联 (Smc).我们专注于硼环烷,它带有一个庞大的 B 取代基,相当于一个末端异二硼烷功能化的间隔基.由于环外 B 取代基的位阻提供硼酸,硼环烷的第一个 Smc 通过内环 B-C 键裂解进行.这些随后在更苛刻的条件下通过转移受阻较小的伯烷基进行第二次smc,以提供不对称双官能化的烷基链.七至五元硼环烷适用于顺序 Smc 反应以提供末端双功能烷烃,尽管五元硼环烷的转化效率比其他的差.为了证明该方法的实用性,
Doi:10.1002/ejoc.201600392

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-9388345-B2
优先权日:2012-07-03
标题:Hydrocarbon synthesis methods, apparatus, and systems
发明人：MCNEFF CLAYTON V; MCNEFF LARRY C; NOWLAN DANIEL THOMAS; YAN BINGWEN; GREUEL PETER G
权利人:SARTEC CORP
摘要:Embodiments of the invention include apparatus and systems for hydrocarbon synthesis and methods regarding the same. In an embodiment, the invention includes a process for creating a hydrocarbon product stream comprising reacting a reaction mixture in the presence of a catalyst inside of a reaction vessel to form a product mixture, the reaction mixture comprising a carbon source and water. The temperature inside the reaction vessel can be between 450 degrees Celsius and 600 degrees Celsius and the pressure inside the reaction vessel can be above supercritical pressure for water. In an embodiment, the invention includes an extrusion reactor system for creating a hydrocarbon product stream. The temperature inside the extrusion reactor housing between 450 degrees Celsius and 600 degrees Celsius. Pressure inside the reaction vessel can be above supercritical pressure for water. Other embodiments are also included herein.

专利号:US-2025282818-A1
优先权日:2022-04-25
标 题:Syrbactin macrolactams and unnatural analogs as proteasome inhibitors for the treatment of multiple myeloma and chemoenzymatic synthesis thereof
发明人：RENATA HANS; AMATUNI ALEXANDER; ADIBEKIAN ALEXANDER; SHUSTER ANTON
权利人:UNIV FLORIDA
摘要:One aspect of the invention is any compound, or salt thereof, described herein. Another aspect is a method of treating a disease, disorder, or symptom thereof, in a subject, comprising administration to the subject of a compound, or salt thereof, herein. Another aspect is a method of inhibiting a proteasome in a subject, comprising administration to the subject of a compound, or salt thereof, herein. Another aspect is a method of making a compound, or salt thereof, described herein using one or more reagents, chemical transformations, or chemical intermediate compounds as described herein.

专利号:US-7811556-B2
优先权日:2003-03-24
标题 :Polymeric modifiers and pharmaceutical compositions
发明人：KASUYA YUJI; HONMA MASASHI
权利人:SANKYO CO
摘要:A copolymer or a pharmacologically acceptable salt thereof is provided, which contains, as constitutional units, (a) one or more structural units of formula (I): wherein m is an integer of from 3 to 100, Alk represents alkyline, and R 1 and R 2 are the same or different and each represents hydrogen or optionally substituted alkyl, and (b) one or more structural units of formula (II): wherein R 3 represents hydroxyl, optionally substituted alkoxy, optionally substituted aryloxy, or a group represented by the formula —NR 4 R 5 , wherein R 4 and R 5 are the same or different and each represents hydrogen or optionally substituted alkyl. There is further provided a pharmaceutical composition comprising said copolymer, a protein modifier comprising said copolymer, a complex of said copolymer with a protein, and method of preventing or treating diseases using said complex, use of said complex in the manufacture of a medicament for preventing or treating diseases and methods for the synthesis of said copolymers and said complexes.

专利号:CN-110746377-A
优先权日:2019-11-07
标 题 :Method for the synthesis of 1-substituted pyrrolidine/piperidine derivatives under supported metal catalysis

专利号:US-7312347-B2
优先权日:2005-09-22
标题 :Substituted optically active disphosphine compound
发明人：FUJIWARA TAKAHIRO; YOKOZAWA TOHRU
权利人:TAKASAGO PERFUMERY CO LTD
摘要:Provided is a method for producing an optically active compound, in more detail, for producing an optically active compound by asymmetric hydrogenation in a high yield and asymmetric yield. The present invention also provides a catalyst for asymmetric synthesis for the above production method, especially a catalyst for asymmetric hydrogenation, containing a transition metal complex. Further, the present invention provides a new diphosphine compound useful as a ligand of the above transition metal complex and a new transition metal complex containing the above diphosphine compound. n The present invention relates to a diphosphine compound represented by the following formula (1): n na transition metal complex using the compound, a catalyst for asymmetric synthesis comprising the above transition metal complex and a method for producing an optically active compound using the above catalyst for asymmetric synthesis.