专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
专利号:US-7482059-B2 优先权日:2004-05-10 标 题:Semiconductor nanocrystal complexes comprising a metal coating and methods of making same 发明人:PENG ADAM; LIU WEI 权利人:EVIDENT TECHNOLOGIES 摘要:A semiconductor nanocrystal complex including a metal layer formed on the outer surface of a semiconductor nanocrystal core after synthesis of the semiconductor nanocrystal core and a method for preparing a nanocrystal complex comprising forming a metal layer on a semiconductor nanocrystal core after synthesis of the semiconductor nanocrystal core. The metal layer may passivate the surface of the semiconductor nanocrystal core and protect the semiconductor nanocrystal core from the effects of oxidation. Also provided is a semiconductor nanocrystal complex with a shell grown onto the metal layer formed on the semiconductor nanocrystal core. In this embodiment, the metal layer may prevent lattice mismatch between the semiconductor shell and the semiconductor nanocrystal core.
专利号:US-2011229397-A1 优先权日:2008-10-03 标 题:Process and apparatus for continuous flow synthesis of nanocrystals 发明人:BARTEL JOSEPH; MCKENZIE LALLIE 权利人:LIFE TECHNOLOGIES CORP 摘要:Novel reactor, systems and methods of preparing nanocrystals in a continuous flow-through process are provided. The novel reactor is highly configurable and can be modified to achieve desired reaction times of a flow through mixture. The reactor is designed to provide uniform, efficient heating of the reaction mixture.
专利号:US-11629137-B2 优先权日:2017-04-24 标 题:Methods of manufacturing of niraparib 发明人:STEWART ALISTAIR; TOTO ANTHONY JOSEPH; CHEN FRANK XING; WU GEORGE 权利人:TESARO INC 摘要:Disclosed herein are methods and processes of preparing niraparib and pharmaceutically acceptable salts thereof, and intermediates and their salts useful for the synthesis of niraparib.
专利号:US-9073761-B2 优先权日:2013-03-11 标题 :Controlled synthesis of nanoparticles using ultrasound in continuous flow 发明人:PALANISAMY BARATH; PAUL BRIAN K; ELURI RAVINDRANADH TAGORE 权利人:UNIV OREGON STATE; OREGON STATE 摘要:Apparatuses and methods for synthesizing nanoparticles are provided. Methods for synthesizing nanoparticles are provided comprising mixing at least two solutions comprising the components of the nanoparticles within a micromixer; exposing the resultant mixed, unreacted, azeotropic solution to ultrasound; and collecting the generated nanoparticles. Apparatuses are also provided for synthesizing nanoparticles comprising a micromixer in fluid connection with a continuous reactor comprising at least one inlet, at least one outlet, and an ultrasound horn oriented such that the acoustic energy is transferred to the fluid within the continuous reactor.
专利号:WO-2008044544-A1 优先权日:2006-10-04 标题 :Fine particle of hydroxide and/or oxide and process for producing the same 发明人:HORIGUCHI SHINICHI; ARIZONO JYUNICHI; OOSHIMA YASUHIRO 权利人:NISSHIN SPINNING; HORIGUCHI SHINICHI; ARIZONO JYUNICHI; OOSHIMA YASUHIRO 摘要:Fine particles of a hydroxide and/or oxide which are produced by electrodialysis; and a process for producing the fine particles. A conductive liquid which is a poor solvent for the hydroxide and/or oxide to be generated in a synthesis chamber is used as a synthesis-chamber liquid. The synthesis chamber is used in combination with a desalting chamber separated from the synthesis chamber by a cation-exchange membrane, the desalting chamber being filled with an aqueous electrolyte solution containing metal ions as a raw material for the hydroxide and/or oxide. A voltage not lower than the theoretical water electrolysis voltage is applied to the chambers. The fine hydroxide and/or oxide particles, which are produced through electrodialysis, are reduced in equipment cost and production cost.
摘要:A19: Zang Y, Odwin-Dacosta S, Yager JD: Effects of cadmium on estrogen receptor mediated signaling and estrogen induced DNA synthesis in T47D human breast cancer cells. Toxicol Lett. 2009 Jan 30;184(2):134-8. doi: 10.1016/j.toxlet.2008.10.032. Epub 2008 Nov 11. 摘要:L468: Wikipedia. Cadmium hydroxide. Last Updated 22 May 2009. http://en.wikipedia.org/wiki/Cadmium_hydroxide