CAS: 156478-71-6; 2-(4-(Tert-Butoxycarbonyl)Piperazin-1-yl)Acetic Acid
该化合物是有机合成的多用途中间体,在制药和丙酸化学中特别有用,其主要结构特征包括:一种受保护的管状素运动和一种箱状酸功能组,能够有选择地修改和同化反应.乙型丁氧碳基(Boc)组在基本条件下提供稳定性,同时允许在温和的酸性条件下进行非保护,使之适合于渐进式合成战略.乙酸侧链会提高溶性,并促进进一步衍生,例如氨化联动.这种化合物通常用于制作生物活性分子,在受控合成应用的再活性和处理稳定性之间求得平衡.
- 英文名称2-(4-(Tert-Butoxycarbonyl)Piperazin-1-yl)Acetic Acid
- 中文名称4-Boc-1-哌嗪乙酸
- IUPAC名称2-(4-(tert-butoxycarbonyl)piperazin-1-yl)acetic acid
- 其它别名4-Boc-1-Piperazineacetic Acid; 2-(4-Boc-1-Piperazinyl)Acetic Acid; 2-[4-[(2-Methylpropan-2-yl)Oxycarbonyl]Piperazin-1-Ium-1-Yl]Acetate; Wzbhmxrbxxcedd-Uhfffaoysa-N; [4-(Tert-Butoxycarbonyl)-1-Piperazinyl]Ace
- CAS编号156478-71-6
- MFCD编号:MFCD02682402
- EINECS号:673-817-9
- FDA UNII编号:QH6363V54T
- 分子式:C11H20N2O4分子量:244.29
- 产品CID: 779188
- 产品分类有机原料→分子砌块→脂肪杂环类化合物→哌嗪类化合物
相似化合物
54699-92-2 1153907-60-8 37478-58-3物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2
严重眼刺激 类别2A
急性毒性 类别5(经口) - 警示词Warning(警告)
- 危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H303 |May be 吞咽有害 - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- 危险等级IRRITANT
- UN编号NONH for all modes of transport
- 危险品标志Xi
- 安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- WGK Germany3
欧盟法规
C&L通报上下游产品
CAS号209667-59-4 4-(2-乙氧基-2-氧代乙基... | CAS号7646-93-7 硫酸氢钾 | CAS号57260-71-6 1-B°C-哌嗪合成工艺路线路线简述
- 合成目标产物 4-Boc-1-Piperazineacetic Acid 主要起始原料 1-Boc-4-Ethoxycarbonylmethylpiperazine
- (文献来源)合成步骤主要原料 1-Boc-4-Ethoxycarbonylmethylpiperazine
📜1-Boc-4-乙氧基羰基甲基哌嗪置于氢氧化钾,水体系中,用 四氢呋喃 用作溶剂,化学反应 2.0H,以37%的收率获得4-Boc-1-哌嗪乙酸
参考文献: Diazepinoindole Derivatives As Kinase Inhibitors[fr] Derives De Diazepinoindole En Tant Qu'Inhibiteurs De Kinase
标题: Diazepinoindole Derivatives As Kinase Inhibitors[fr] Derives De Diazepinoindole En Tant Qu'Inhibiteurs De Kinase
摘要:蛋白激酶,如chk-1,抑制以下式的三环化合物(其中r2,R3和r4如规范中定义)的药物组合物,含有所述化合物或其盐的有效量,可用作单一药剂或与抗肿瘤药剂或具有抗肿瘤效果的治疗放射剂结合,用于治疗疾病或病况,如癌症.
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2023295613-A1
优先权日:2020-02-14
标 题:Long chain carbon and cyclic amino acids substrates for genetic code reprogramming
发明人：JEWETT MICHAEL C; LEE JOONGOO; MOORE JEFFREY S; SCHWARZ KEVIN J
权利人:UNIV NORTHWESTERN; UNIV ILLINOIS
摘要:Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.
专利号:US-11814621-B2
优先权日:2018-06-01
标题 :Expanding the chemical substrates for genetic code reprogramming
发明人：JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; MOORE JEFFREY S; SCHWIETER KENNETH E; SCHWARZ KEVIN JEROME
权利人:UNIV NORTHWESTERN; UNIV ILLINOIS
摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.
