CAS: 15486-33-6; 3,5-Dihydroxy-7-Methoxy-2-(4-Methoxyphenyl)-4H-Chromen-4-One

上下游产品

4'-O-methylkaempferol dimethyl sulfate kaempferol 5,7,4'-trimethyl ether t,5-dihydroxy-7-methoxy-2r-(4-methoxy-phenyl)-chroman-4-one(+/-)-3t,5-dihydroxy-7-methoxy-2r-(4-methoxy-phenyl)-chroman-4-one 5-hydroxy-3,4',7-trimethoxyflavone 3,4',5,7-tetramethoxyflavone

📜山奈酚置于吡啶,咪唑,N-甲基吡咯烷酮,Potassium Carbonate,苯硫酚体系中,用 甲醇,丙酮 用作溶剂,化学反应 37.0H,反应生成3,5-二羟基-4',7-二甲氧基黄酮
参考文献:Selective Methylation Of Kaempferol Via Benzylation And Deacetylation Of Kaempferol Acetates
标题:Selective Methylation Of Kaempferol Via Benzylation And Deacetylation Of Kaempferol Acetates
摘要:开发了一种选择性对卡培菲醇进行单甲基化,二甲基化和三甲基化的策略,主要基于对卡培菲醇醋酸酯的选择性苄基化和可控的去乙酰化.通过对卡培菲醇四乙酰酸酯(1)的选择性去乙酰化和苄基化,分别得到了3,4',5-三乙酰卡培菲醇(2)和7-苄基-3,4'5-三乙酰卡培菲醇(8).通过可控的去乙酰化,然后对这两种中间体进行选择性或直接的甲基化,从卡培菲醇中总产率为51-77%制备了八种甲基化卡培菲醇.
Doi:10.3762/bjoc.11.33

专利信息

专利号:US-7816544-B2
优先权日:2004-03-23
标 题:Synthesis of rocaglamide natural products via photochemical generation of oxidopyrylium species
发明人：JONES II GUILFORD; GERARD BAUDOUIN; PORCO JR JOHN A
权利人:UNIV BOSTON
摘要:The present invention provides new strategies for the synthesis of compounds of the rocaglamide family and related natural products. In particular, the new biomimetic synthetic approach involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile. This approach can be used for the formation of adducts containing an aglain core structure. Methods for the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-κB-dependent conditions.

专利号:US-8404088-B2
优先权日:2006-05-22
标 题:Asymmetric synthesis of rocaglamides via enantioselective photocycloaddition mediated by chiral bronsted acids
发明人：PORCO JR JOHN A; GERARD BAUDOUIN
权利人:PORCO JR JOHN A; GERARD BAUDOUIN; UNIV BOSTON
摘要:The present invention provides a new strategies for the synthesis of compounds of the rocaglamide family and related natural products. The synthetic approach generally involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by an enantioselective 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile in the presence of a TADDOL derivative. This approach can be used for the formation of adducts containing an aglain core structure. Methods of the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-κB-dependent conditions.

专利号:US-2008177093-A1
优先权日:2004-03-23
标题 :Synthesis of Rocaglamide Natural Products Via Photochemical Generation of Oxidopyrylium Species

专利号:WO-2005092876-A1
优先权日:2004-03-23
标 题 :Synthesis of rocaglamide natural products via photochemical generation of oxidopyrylium species

专利号:US-2011065786-A1
优先权日:2004-03-23
标题:Synthesis of rocaglamide natural products via photochemical generation of oxidopyrylium species

专利号:US-2012238766-A1
优先权日:2006-05-22
标题:Asymmetric synthesis of rocaglamides via enantioselective photocycloaddition mediated by chiral bronsted acids