CAS: 1445-91-6; (S)-1-Phenylethanol

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CAS号98-86-2 苯乙酮 | CAS号292638-84-7 phenylene-ethylene | CAS号585-74-0 间甲基苯乙酮 | CAS号51276-65-4 diphenyl(1-phen... | CAS号98-85-1 苏合香醇 | CAS号75-24-1 三甲基铝 | CAS号100-52-7 苯甲醛 | CAS号544-97-8 二甲基锌 | CAS号38053-74-6 1-phenyl-1-tric... | CAS号108-22-5 醋酸异丙烯酯 | CAS号10531-50-7 (R)-(-)-Α-三氟甲基苄醇 | CAS号340-06-7 (S)-(+)-Α-三氟甲基苄醇 | CAS号98-85-1 苏合香醇 | CAS号536-50-5 1-(4-甲基苯基)乙醇 | CAS号98-86-2 苯乙酮 | CAS号292638-84-7 phenylene-ethylene | CAS号93-92-5 乙酸苏合香酯 | CAS号492-37-5 2-苯基丙酸

D-扁桃酸置于吡啶,Lithium Aluminium Tetrahydride,硼烷四氢呋喃络合物体系中,用 四氢呋喃 用作溶剂,化学反应 12.0H,反应生成(S)-(-)-1-苯乙醇
参考文献:大鼠肝谷胱甘肽s-转移酶同工酶催化的共轭反应的立体化学方面.
标题:大鼠肝谷胱甘肽s-转移酶同工酶催化的共轭反应的立体化学方面.
摘要:用大鼠肝脏部分纯化的同工酶研究了谷胱甘肽s-转移酶催化的卤代苯乙基卤化物结合中的底物对映选择性.测试的所有同工酶均具有与苯乙基氯可测量的活性.转移酶a是测试最活跃的同工酶.每种同工酶都表现出高度的底物对映选择性,其中转移酶a是最对映选择性的同工酶.通过酶促形成的非对映体产物的高压液相色谱分析确定对映选择性.研究了限制谷胱甘肽浓度对转移酶的立体化学结果的影响.手性底物(S)-苯乙基氯化物(4 Mm)催化了偶联反应.在低至25 Microm的谷胱甘肽浓度下,酶促反应的立体化学过程没有明显改变.共轭作用的主要产物在苄基碳上具有相反的立体化学,表明该反应主要以构型反转进行.研究了谷胱甘肽共轭物s-[((R)-1-苯基乙基]谷胱甘肽,S-[((S)-1-苯基乙基]谷胱甘肽,S-苄基谷胱甘肽和s-甲基谷胱甘肽)作为转移酶a抑制剂的催化共轭1-氯-2,4-二硝基苯.抑制效力的顺序是:S-[((S)-1
Doi:10.1021/jm00355A014

专利信息

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:US-6451727-B2
优先权日:1997-11-12
标题:Catalysts for use in asymmetric synthesis comprising transition metals and chiral amine oxazolinyl ligands
发明人：ZHANG XUMU
权利人:PENN STATE RES FOUND
摘要:The invention is drawn to transition metal catalysts for the practical synthesis of important chiral molecules. The transition metal catalysts comprise chiral ligands based on chiral amine oxazolinyl ligands. The invention includes methods of making the catalysts, and methods of performing reactions using the catalysts.

专利号:US-6380416-B2
优先权日:1997-06-13
标题:Asymmetric synthesis catalyzed by transition metal complexes with rigid chiral ligands
发明人：ZHANG XUMU
权利人:PENN STATE RES FOUND
摘要:This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.

专利号:US-8350042-B2
优先权日:2008-01-31
标题 :Antiviral compounds for the treatment of HCV infection
发明人：HERMANN THOMAS C; CARNEVALI MAIA
权利人:UNIV CALIFORNIA; HERMANN THOMAS C; CARNEVALI MAIA
摘要:Disclosed are compounds and methods of synthesis of Formula I for the development of antiviral drugs for the treatment of HCV infection.

专利号:US-5097051-A
优先权日:1989-02-10
标题 :Cyclic triketone compounds and trimethylsilyloxy butadiene compounds and their use in the preparation of daunomycinone derivatives
发明人：SCHEEREN JOHAN W; DEBIE JOANNES F M; DEVOS DIRK
权利人:PHARMACHEMIE BV
摘要:The invention provides novel cyclic triketone compounds of the formulae wherein S is H, alkyl or alkoxy and R* is a group of the formule wherein R<1> is methyl and R2 is an alkyl group containing at least 2 carbon atoms, or R<1> is an alkyl group having 1-4 carbon atoms and R<2> is an aryl group, a hetero aryl group, a -CH2OR min , a -CH2N @@ group, a -CH2SR sec group or a -CH2CH=CH2 group, wherein R min and R sec are alkyl groups having 1-4 carbon atoms. These compounds can be used for preparing daunomycinone and derivatives thereof. Daunomycinone is used for preparing daunomycin and adriamycin. By introducing chirality at C-1 of ring A in the preparation of said novel compounds by using a novel diene of formula (1) in a Diels-Alder reaction for said preparation, the chirality of C-3 is established in the subsequent reaction with LiC IDENTICAL CSi(CH3)3 in the synthesis of daunomycinone and derivatives thereof. This last reaction leads to the desired compound wherein OH at C-3 and OR at C-1 are in the cis-position with respect to each other.

专利号:US-5183913-A
优先权日:1989-02-10
标 题 :Cyclic triketone compounds and trimethylsilyoxy butadiene compounds and their use in the preparation of daunomycinone derivatives
发明人：SCHEEREN JOHAN W; MARTINUS DE BIE JOANNES F; DE VOS DIRK
权利人:PHARMACHEMIE BV
摘要:The invention provides novel cyclic triketone compounds of the formulae (2) (3) wherein S is H, alkyl or alkoxy and R* is a group of the formule wherein R1 is methyl and R2 is an alkyl group containing at least 2 carbon atoms or R1 is an alkyl group having 1-4 carbon atoms and R2 is an aryl group, a hetero aryl group, a -CH2OR' group, a -CH2N (1) This last reaction leads to the desired compound wherein OH at C-3 and OR at C-1 are in the cis-position with respect to each other.