专利号:US-6828466-B2 优先权日:2002-07-19 标题:Process for the synthesis of phenols from arenes 发明人:MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG 权利人:UNIV MICHIGAN STATE 摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.
专利号:US-5149814-A 优先权日:1987-09-30 标 题:Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds 发明人:COOPER KELVIN; FRAY MICHAEL J; RICHARDSON KENNETH; STEELE JOHN 权利人:PFIZER 摘要:Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R 3 is lower alkyl; Y is 1,4-phenylene and X is 2-alkylimidazopyridyl.
专利号:US-2004030197-A1 优先权日:2002-07-19 标 题 :Process for the synthesis of phenols from arenes
专利号:US-5070205-A 优先权日:1987-09-30 标 题:Alkyl 2-benzylidene-4-(benzimidazol-1-yl) benzoylacetate esters as intermediates 发明人:COOPER MELVIN; FRAY MICHAEL J; RICHARDSON KENNETH; STEELE JOHN 权利人:PFIZER 摘要:Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R 3 is lower alkyl; Y is 1,4-phenylene and X is a benzimidazol-1-yl.
专利号:RU-2072990-C1 优先权日:1992-03-31 标 题:Method of synthesis of 2,6-dimethyl-3,5-dichloro-4(1h)-pyridone