34635-34-2 = 13505-32-3 + 86117-53-5 反应条件:1.1 Reagents: (3R,5R,6S,8R)-1,3,4,5,6,7,8,10-Octahydro-5,6-Bis(2-Hydroxyphenyl)-3,8-Bis(Phenyl... Solvents: Chloroform-D; Rt 标题:Synthesis Of Macrocycles And Their Application As Chiral Solvating Agents In The Enantiomeric Recognition Of Carboxylic Acids And α-Amino Acid Derivatives 作者:Guo,Shengnan; Et Al 参考文献:Tetrahedron: Asymmetry 日期:2013 卷标:24(8) 页码:480-491
N-(对甲苯磺酰基)苯丙氨酸(9-甲氧基-3-氧代-3H-苯并[f]苯并吡喃-1-基)甲酯 以 乙腈 用作溶剂,化学反应生成N-(对甲苯磺酰)-L-苯丙氨酸 参考文献:氧代苯并[ F ]苯并吡喃类作为新的对羧基具有功能的荧光光不稳定保护基 标题:氧代苯并[ F ]苯并吡喃类作为新的对羧基具有功能的荧光光不稳定保护基 摘要:研究了三个氧代苯并[ F ]苯并吡喃类作为新的对氨基酸的羧基官能团的光不稳定保护基的性质.荧光氨基酸缀合物得到了有效的制备和表征.这些化合物的光脱保护是通过在300,350和419 Nm处进行辐照进行的,最短的辐照时间和非常好的脱保护收率是最合适的波长是350 Nm. Doi:10.1016/j.Tet.2006.09.085
专利号:US-7588887-B2 优先权日:1998-08-31 标题 :Stable isotope metabolic labeling for analysis of biopolymers 发明人:FRANZA JR B ROBERT; ROCHON YVAN P 权利人:UNIV WASHINGTON 摘要:Methods for the determination of the rate of synthesis of biopolymer synthesis and degradation in cells, tissues, or cell-free systems using monomer which has been labeled with a stable isotope are provided. Further, the present invention provides methods for the determination or identification of an unknown biopolymer and for the identification of an unknown cell type, a physiological state of a cell or tissue. Also, the present invention provides a database of descriptors which can be used to define an organism, tissue type, cell type, and the like, and which database can be used in conjunction with other public and private databases to identify or characterize an organism, tissue type, cell type, state of differentiation, or physiologic state of an organism, or tissue or cell sample.
专利号:US-10947231-B2 优先权日:2009-05-27 标题:Processes for the preparation of substituted tetrahydro beta-carbolines 发明人:HWANG PETER SEONGWOO; MOON YOUNG-CHOON; TAMIL ARASU; QI HONGYAN; ALMSTEAD NEIL 权利人:PTC THERAPEUTICS INC 摘要:Provided herein are improved processes for the synthesis of substituted tetrahydro beta-carboline derivatives. In particular, provided herein are improved processes useful for the preparation of (S)-4-chlorophenyl 6-chloro-1-(4-methoxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate. Formula (I):
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
摘要:Aitken, R. A.; Meehan, A., Science of Synthesis Knowledge Updates, (2014) 3, 149. 参考文献:10.1007/bf02478922 摘要:Uematsu Y, Tanaka Y, Shimizu M, Oobayashi S, Fujita K, Nakai K, Itakura T, Moriwaki H, Kamei I. Histogenesis and proliferative activity of central neurocytomas. Brain Tumor Pathol. 2001;18(1):29–36. doi: 10.1007/bf02478922. 参考文献:10.1023/a:1014880403970 摘要:Leal RB, Sim AT, Gonçalves CA, Dunkley PR. Tyrosine hydroxylase dephosphorylation by protein phosphatase 2A in bovine adrenal chromaffin cells. Neurochem Res. 2002 Mar;27(3):207–13. doi: 10.1023/a:1014880403970. 参考文献:10.1007/978-1-61779-126-0_7 摘要:Davey J, Ladds G. Heterologous expression of GPCRs in fission yeast. Methods Mol Biol. 2011;746():113–31. doi: 10.1007/978-1-61779-126-0_7. 参考文献:10.1023/b:cbto.0000004975.36521.c8 摘要:Chadebech P, Goidin D, Jacquet C, Viac J, Schmitt D, Staquet MJ. Use of human reconstructed epidermis to analyze the regulation of beta-defensin hBD-1, hBD-2, and hBD-3 expression in response to LPS. Cell Biol Toxicol. 2003 Oct;19(5):313–24. doi: 10.1023/b:cbto.0000004975.36521.c8.