专利号:WO-2024256322-A1 优先权日:2023-06-13 标题 :Synthesis of non-ionic radiographic contrast agents by means of reactive extrusion 发明人:LATTUADA LUCIANO; SEBASTIANO ROBERTO; LEONARDI GABRIELLA; CRAVOTTO GIANCARLO; BARGE ALESSANDRO; BUCCIOL FABIO 权利人:BRACCO IMAGING SPA; MILANO POLITECNICO 摘要:The present invention relates to the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a process for the synthesis of lopamidol using a reactive extrusion process in continuous which enable an efficient conversion of the relevant key intermediates, preferably in the absence of any solvent. The invention further relates to the preparation of radiographic X-rays contrast agents or key intermediates thereof by exploiting the technology of reactive extrusion.
专利号:US-5122566-A 优先权日:1989-10-06 标 题 :Latex for coatings having reduced blushing characteristics 发明人:BURROWAY GARY L; GESENHUES ALBERT M; BRADEN JENNIFER T 权利人:GOODYEAR TIRE & RUBBER 摘要:This invention relates to the synthesis of a latex which can be formulated into coatings having improved water resistance for both moisture vapor transmission and water spotting. Coatings which are formulated with the latex of this invention are particularly useful for coating metal substrates because they provide excellent rust and corrosion resistance. The subject invention more specifically discloses a process for producing a neutralized latex that is useful in the manufacture of water reducible coatings which comprises: (1) free radical aqueous emulsion polymerizing at a pH of less than about 3.5 a monomer mixture which comprises, based on 100 weight percent monomers: (a) from about 45 to about 85 weight percent vinyl aromatic monomers, (b) from about 15 to about 50 weight percent of at least one alkyl acrylate monomer, and (c) from about 1 to about 6 weight percent of at least one unsaturated carbonyl compound; in the presence of about 0.5 to 4.0 phm at least one phosphate ester surfactant and in the presence of about 0.5 to 4.0 phm of at least one water insoluble nonionic surface active agent to produce a latex; and (2) neutralizing the latex with ammonia to a pH which is within the range of about 7 to a bout 10.5 to produce the neutralized latex.
专利号:CN-109790382-B 优先权日:2016-09-28 标 题:Solvent systems for the synthesis of poly(amic acid) and polyimide polymers
专利号:US-4968741-A 优先权日:1989-10-06 标题:Latex for coatings having reduced blushing characteristics 发明人:BURROWAY GARY L; GESENHUES ALBERT M; BRADEN JENNIFER T 权利人:GOODYEAR TIRE & RUBBER 摘要:This invention relates to the synthesis of a latex which can be formulated into coatings having improved water resistance for both moisture vapor transmission and water spotting. Coatings which are formulated with the latex of this invention are particularly useful for coating metal substrates because they provide excellent rust and corrosion resistance. The subject invention more specifically discloses a process for producing a neutralized latex that is useful in the manufacture of water reducible coatings which comprises: n (1) free radical aqueous emulsion polymerizing at a pH of less than about 3.5 a monomer mixture which comprises, based on 100 weight percent monomers: (a) from about 45 to about 85 weight percent vinyl aromatic monomers, (b) from about 15 to about 50 weight percent of at least one alkyl acrylate monomer, and (c) from about 1 to about 6 weight percent of at least one unsaturated carbonyl compound; in the presence of about 0.5 to 4.0 phm at least one phosphate ester surfactant and in the presence of about 0.5 to 4.0 phm of at least one water insoluble nonionic surface active agent to produce a latex; and n (2) neutralizing the latex with ammonia to a pH which is within the range of about 7 to about 10.5 to produce the neutralized latex.
专利号:CN-107099560-A 优先权日:2017-04-24 标题 :A kind of method and application of microwave-assisted enzymatic synthesis of kojic acid lauric acid monoester in ionic liquid
专利号:US-11332462-B2 优先权日:2012-02-08 标 题 :Heteroaryl compounds and methods of use thereof 发明人:CAMPBELL JOHN EMMERSON; CAMPBELL UNA; HANANIA TALEEN G; SHAO LIMING 权利人:SUNOVION PHARMACEUTICALS INC; PGI DRUG DISCOVERY LLC 摘要:Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
1: Zhang SH, Shen YX, Li L, Fan TT, Wang Y, Wei N. Phthalate exposure and high blood pressure in adults: a cross-sectional study in China. Environ Sci Pollut Res Int. 2018 Jun;25(16):15934-15942. doi: 10.1007/s11356-018-1845-1. Epub 2018 Mar 27. doi: 10.1016/j.ecoenv.2016.08.028. Epub 2016 Sep 10. doi: 10.1371/journal.pone.0161167. eCollection 2016. 5: Hu JH, Feng T, Li WL, Zhai H, Liu Y, Wang LY, Hu CL, Xie MX. Surface molecularly imprinted polymers with synthetic dummy template for simultaneously selective recognition of nine phthalate esters. J Chromatogr A. 2014 Feb 21;1330:6-13. doi: 10.1016/j.chroma.2014.01.008. Epub 2014 Jan 13. doi: 10.1111/j.1574-695X.2007.00355.x. Epub 2007 Dec 20.
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