相似化合物
5407-04-5 114326-14-6 365432-21-9物理性质
- 熔点168 °C
- 沸点130.7°C at 760 mmHg
- 闪点32.8±22.6°C
- 密度0.9±0.1 g/cm3
- pKa:9.24±0.28(预测)
- PSA:3.24
- LogP:1.1769
- 折射率1.434
- 蒸汽压9.6±0.2 mmHg at 25°C
- 溶解性Chloroform (Sparingly), Methanol (Slightly)
- 敏感性空气敏感
- 外观形态无色液体
- 储存条件惰性气氛,存放于冰箱中, -20°C
- 产品应用氯丙嗪,炎痛静,泰尔登,丙咪嗪,多虑平,阿米替丁的中间体.
- 性质描述液体.沸点140°C,33-35°C/2.4kPa,折光率1.4502,有刺激性.盐酸盐为结晶,熔点142°C,吸湿,有刺激性.
欧盟法规
REACH注册ECHA物质C&L通报REACH预注册上下游产品
CAS号5407-04-5 3-二甲氨基氯丙烷盐酸盐 | CAS号124-40-3 二甲胺 | CAS号109-70-6 1-溴-3-氯丙烷 | CAS号3179-63-3 3-二甲氨基-1-丙醇 | CAS号20904-57-8 N,N-dimethyl-3-... | CAS号17268-49-4 3-氯-N,N-二甲基丙酰胺 | CAS号30340-95-5 N,N-Dimethylaze... | CAS号926-63-6 N,N-二甲基丙胺 | CAS号67-66-3 氯仿 | CAS号7782-50-5 氯气 | CAS号10404-34-9 5-(dimethylamin... | CAS号3529-10-0 N,N-二甲基1,4-丁二胺 | CAS号50-53-3 氯丙嗪 | CAS号19607-03-5 2-chloro-10-met... | CAS号63615-79-2 10-烯丙基-2-氯吩噻嗪 | CAS号18029-54-4 5-[3-(二甲基氨基)丙基]... | CAS号50-49-7 米帕明 | CAS号91430-80-7 N,N-二甲基-3-(4-硝基... | CAS号3926-64-5 2-羟基丙嗪 | CAS号5118-29-6 美利蒽合成工艺路线路线简述
- 合成目标产物 3-Chloro-1-(N,N-Dimethyl)Propylamine 主要起始原料 3-(Dimethylamino)Propyl Chloride Hydrochloride
- (文献来源)合成步骤主要原料 3-(Dimethylamino)Propyl Chloride Hydrochloride
N,N-Dimethylazetidinium-Chlorid 反应生成N,N-二甲基-3-氯丙胺
参考文献:Lapshin,N.M. Et Al.,Journal Of Organic Chemistry Ussr (English Translation),1970,Vol. 6,# 10,P. 2035-2037
标题:Lapshin,N.M. Et Al.,Journal Of Organic Chemistry Ussr (English Translation),1970,Vol. 6,# 10,P. 2035-2037
专利信息
专利号:US-2008119662-A1
优先权日:2004-02-16
标 题:One Spot Synthesis of Citalopram from 5-Cyanophthalide
发明人:NARAHARI BABU AMBATI; SRINIVAS GOUD VUDDAMARI; GAONKAR SANTOSH LAXMAN; MANJUNATHA SULUR G; KULKARNI ASHOK KRISHNA; KULKARNI MADHARI A
权利人:JUBILANT ORGANOSYS LIMTED
摘要:A process for one pot synthesis of citalopram is disclosed. The process comprises subjecting 5-cyano phthalide to Grignard reduction followed cyclization and followed by C-alkylation reaction to obtain citalopram without isolation and purification of any intermediates. In another embodiment, 5-cyano phthalide is subjected to sequential Grignard reactions followed by cyclization to obtain citalopram without isolation and purification of any intermediate stages.
专利号:US-7576234-B2
优先权日:2002-05-15
标题 :Synthesis of 2-alkyl amino acids
发明人:CHORGHADE MUKUND S; GURJAR MUKUND K; MOHAPATRA DEBENDRA K
权利人:GENZYME CORP
摘要:Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.
专利号:US-2024324437-A1
优先权日:2023-03-22
标题 :Tunable polymer transport materials for application in perovskite solar cells
发明人:SELLINGER ALAN; ASTRIDGE DANIEL; LEVIN JACOB
权利人:COLORADO SCHOOL OF MINES
摘要:Polymer transport materials for application in perovskite solar cells capable of being tuned or manipulated to achieve desired properties, are provided herein. The present disclosure is directed to methods, systems, and compositions for achieving polymer transport materials (i.e., hole transport materials (HTMs)) with desirable properties such as solution processability, energy level tuning (i.e., adjusting), high thermal properties, tunable (i.e., adjustable) wettability, and perovskite defect passivation. In some aspects of the present disclosure, the synthesis of such HTMs may be implemented via relatively simple and inexpensive processes.
专利号:US-8399502-B2
优先权日:2008-09-17
标 题 :Analogs of indole-3-carbinol and their use as agents against infection
发明人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN
权利人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN; STANFORD RES INST INT
摘要:Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.
专利号:US-5432163-A
优先权日:1992-11-13
标题:Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides
发明人:AKHTAR M NAYEEM; THOMSON DAVID S; ARORA SUDERSHAK K
权利人:GREENWICH PHARMA
摘要:Compounds of this invention are derivatives of pentose monosaccharides which exhibit anti-proliferative and anti-inflammatory activity as well as intermediates for the synthesis of these compounds. Methods of preparation, pharmaceutical compositions containing the compounds and methods of treating inflammatory and/or autoimmune disorders employing the compounds are disclosed.
专利号:US-5344924-A
优先权日:1991-02-20
标 题 :Solvent-free synthesis of ethereally substituted blocked monosaccharides and the selective hydrolysis thereof
发明人:ARORA SUDERSHAN K
权利人:GREENWICH PHARMA
摘要:A solvent-free method for synthesizing an ethereally-substituted, blocked monosaccharide comprising the steps of: n 1) mixing, in the absence of solvent, a partially blocked monosaccharide unblocked at one position, an alkyl halide or a substituted alkyl halide, and an anhydrous alkali base; n 2) heating the mixture to a temperature sufficient to allow the mixture to react; n 3) maintaining the mixture at a suitable temperature for a time sufficient to form an ethereally-substituted blocked monosaccharide and drive off any water produced; n 4) removing any unreacted alkyl halide or substituted alkyl halide from the mixture; n 5) recovering the ethereally-substituted blocked monosaccharide product from the mixture; and, optionally, n 6) selectively hydrolyzing the ethereally-substituted blocked monosaccharide product to remove one or more of the acetal blocking groups.