专利号:WO-2015198349-A1 优先权日:2014-06-25 标 题 :A one pot synthesis of 3-substituted quinoline carboxylates and its derivatives 发明人:GADAKH SUNITA KHANDERAO; SUDALAI ARUMUGAM 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides a one pot, simple, cost effective and industrially feasible catalytic synthesis of quinolines or substituted quinolines from anilines with yield >80% yield. The present invention also discloses a process for the synthesis of oxolinic acid using quinolines with yield > 45%.
专利号:US-9346743-B2 优先权日:2012-10-15 标题 :Processes for the synthesis of 2-amino-4,6-dimethoxybenzamide and other benzamide compounds 发明人:THAKKAR AMIT; ZEILER ANDREW G; SKUFCA ANTHONY F; SPRINGER JAMES J; ASSINK BRYCE KELLY; LOZANOV MARIO E 权利人:ALBEMARLE CORP 摘要:This invention provides a method for the synthesis of a 2-amino-4,6-dimethoxybenzamide and other benzamides of Compound I: wherein R 1 , R 2 , R 3 , and R 4 each independently represent a hydrogen, a C 1 -C 6 alkyl, or a C 1 -C 6 alkoxy; and wherein R 6 and R 7 each independently represent a hydrogen, a C 1 -C 6 alkyl, a protecting group, or a directing group.
专利号:US-8884046-B2 优先权日:2012-10-15 标 题:Compounds useful in the synthesis of benzamide compounds 发明人:LOZANOV MARIO EMILOV; SKUFCA ANTHONY FRANK; ZEILER ANDREW GEORGE 权利人:LOZANOV MARIO EMILOV; SKUFCA ANTHONY FRANK; ZEILER ANDREW GEORGE; RESVERLOGIX CORP 摘要:Compounds that are useful in the synthesis of 2-amino-4,6-dimethoxybenzamide derivatives and other benzamide compounds.
专利号:WO-9931124-A1 优先权日:1997-12-12 标 题:Cholic acid-based scaffolds for multidimensional molecular presentation of peptides 发明人:HOEEG-JENSEN THOMAS 权利人:NOVO NORDISK AS; HOEEG JENSEN THOMAS 摘要:A solid phase method for the synthesis of a plurality of differently substituted cholic acid scaffolds with a wide variety of peptide chain, pseudo-peptide chain or peptoid chain substitutents, as leads or compounds of potential therapeutic interest. The substituted cholic acids are prepared by initial solution synthesis of a scaffold holding amino acids with 3 orthogonal protecting groups. Subsequent solid-phase synthesis provides the build-up of the target molecules, either as discretes or in mixture. The molecules may be screened on the resin or cleaved from the resin and then screened in solution. The method disclosed here provides an easy and fast access to highly diverse compounds, potential peptide mimetics and potential leads for compounds of therapeutic interest. The method is amenable to automatization.
专利号:US-11130764-B2 优先权日:2017-02-17 标题 :Analogs of vincamine and uses thereof 发明人:HUIGENS III ROBERT WILLIAM; NORWOOD IV VERRILL M; LUESCH HENDRIK 权利人:UNIV FLORIDA 摘要:The present disclosure provides compounds of any one of Formulae (I′), (I), (IA), (II′), (II), (IIA), (IIIA), (III″), (III′), (III), (IIIA), (IV), (V′), (V), (VI), (VII), (VIII′), (VIII), (IX′), (IX), and (X). The compounds described herein may be useful in treating and/or preventing a broad range of diseases (e.g., proliferative disease (e.g., cancers (e.g., non-small cell lung cancer, or glioma), inflammatory diseases, autoimmune diseases), CNS disorder (e.g., drug addiction), metabolic disorder (e.g., diabetes), or infectious disease (e.g., bacterial infection or parasitic infection (e.g., malaria))). Also provided in the present disclosure are pharmaceutical compositions, methods of synthesis of a compound described herein, kits, methods, and uses including or using a compound described herein.
专利号:US-6045755-A 优先权日:1997-03-10 标题 :Apparatus and method for combinatorial chemistry synthesis 发明人:LEBL MICHAEL; POKORNY VIT; KRCHNAK VIKTOR 权利人:TREGA BIOSCIENCES INC 摘要:In a first embodiment, this invention includes an integrated robot apparatus for performing combinatorial chemistry synthesis protocols and having interchangeable work-stations, robot arm tools, and reaction vessels and reaction vessel arrays. The work-stations and tools are specialized to perform tasks necessary for the synthesis in a plurality of the reaction vessels grouped in a plurality of the reaction vessel arrays. Preferably, these elements function interchangeably because they have standardized sizes and conformation. The work-stations and tools include those for fluid dispensing or aspirating from individual reaction vessels or from all the reaction vessels in an array simultaneously. The reaction vessels can include, alternatively, stackable, ball-sealed reaction vessels, microtitre-like reaction vessel arrays, arrays of independent reaction vessels, valve-sealed reaction vessels, septum-sealed reaction vessels, and syringe reaction vessels. In alternative embodiments, this invention includes these work-stations, tools, reaction vessels and reaction vessel arrays in various combinations or sub-combinations either for use in partially integrated robots or for manual or standalone use.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 322. 摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 89. 摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 78. 摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 338. 摘要:Kang, F.-A.; Yang, S.-M., Science of Synthesis Knowledge Updates, (2015) 2, 204.