CAS: 97455-65-7; 6-Ethoxynicotinic Acid

该化合物是一种多用途的七环化合物,其特点是碳酸和乙氧功能组,使其成为有机合成和制药应用中有价值的中间体.它的核提供了稳定性和再活性,而乙氧替代成分则增强了溶解性和调制电子特性. 碳oxylic酸组允许进一步衍生,从而能够形成氨化物,酯或其他衍生物. 该化合物在药用化学中特别有助于生物活性分子,农用化学化学物和化学协调的开发. 其明确界定的结构和功能组的兼容性使它成为研究和工业应用的可靠建筑.

结构式图片

相似化合物

97455-61-3 223127-05-7 106853-78-5

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号64-17-5 乙醇 | CAS号1198164-31-6 6-ethoxy-N-meth... | CAS号5326-23-8 6-氯烟酸

合成工艺路线路线简述

  • 5326-23-8 = 97455-65-7
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Dimethyl Sulfoxide; Rt; 22 H,70 - 80 °C; 80 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,Cooled
    标题:6-Substituted Nicotinic Acid Analogues,Potent Inhibitors Of Caiii,Used As Therapeutic Candidates In Hyperlipidemia And Cancer
    作者:Mohammad,Haneen K.; Alzweiri,Muhammed H.; Khanfar,Mohammad A.; Al-Hiari,Yusuf M.
    参考文献:Medicinal Chemistry Research 日期:2017 卷标:26(7) 页码:1397-1404]

    49608-01-7 = 97455-65-7 + 1016756-23-2
    反应条件:1.1 Reagents: Potassium Tert-Butoxide Solvents: Tetrahydrofuran; 5 Min,0 °C1.2 0 °C; 0 °C -> Rt; 2 H,Rt1.3 Reagents: Sodium Chloride Solvents: Water1.4 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; Overnight,35 °C1.5 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
    标题:Preparation Of Heteroarylchromenylbenzamide Derivatives And Analogs As Voltage-Gated Sodium Channel Modulators
    参考文献:World Intellectual Property Organization]

    5326-23-8 = 97455-65-7
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Ethanol,Dimethyl Sulfoxide; Rt; 21 H,100 °C
    标题:Preparation Of Triazine-Oxadiazoles For The Treatment Of Chronic Pain
    参考文献:World Intellectual Property Organization]

    5326-23-8 = 97455-65-7 [标题:Reaction Conditions
    标题:Preparation Of N-Pyridylalkyl-1-[(Hetero)Aryl]Aminoethanols As Animal Growth Stimulants And Antiobesity Agents
    参考文献:European Patent Organization]

    5326-23-8 = 97455-65-7 [标题:Reaction Conditions
    标题:Preparation Of Nitromethylene Derivatives And Their Intermediates As Insecticides
    参考文献:Japan]

    = 97455-65-7 [标题:Reaction Conditions
    标题:Nitromethylene Derivatives,Intermediates,And Their Preparation As Insecticides
    参考文献:European Patent Organization
📜6-氯烟酸 反应生成 6-乙氧基烟酸
参考文献:Shiokawa,Kozo;Tsuboi,Shinichi;Kagabu,Shinzo;Moriya,Koichi
标题:Shiokawa,Kozo;Tsuboi,Shinichi;Kagabu,Shinzo;Moriya,Koichi

海关参考信息

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1016/j.bbrc.2023.08.050
摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.
参考文献:10.1021/acsmedchemlett.4c00190
摘要:Citarella A, Cavinato M, Rosini E, Shehi H, Ballabio F, Camilloni C, Fasano V, Silvani A, Passarella D, Pollegioni L, Nardini M. Nicotinic Acid Derivatives As Novel Noncompetitive α-Amylase and α-Glucosidase Inhibitors for Type 2 Diabetes Treatment. ACS Med. Chem. Lett. 2024 Aug 05;15(9):1474–81. doi: 10.1021/acsmedchemlett.4c00190.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知