CAS: 877133-54-5; 4-Bromo-2,6-Diethylpyridine

该化合物是一种有机化合物,其特征是其环,这是一个六人组成的芳香热循环,含有一个氮原子;在环的2和6个位置上存在两个乙基组,造成其疏水性,影响其在有机溶剂中的溶解性;4号位置的溴替代成分引入一种卤素,它可以增强化合物的再活动,特别是在核生殖反应中.这种化合物一般是无色的,不光色的黄色液体或固体,视其体温的物理状态而定.其分子结构允许有机合成,制药和农用化学品的潜在应用.此外,溴原子的存在可能带来具体的生物活动,引起对医药化学的兴趣.与许多有机化合物一样,在处理4-溴-2,6-二乙基-丙烯时,由于潜在的毒性和环境影响,应当采取安全防范措施.

结构式图片

相似化合物

156761-88-5 908267-63-0 935-28-4

物理性质

MSDS等安全信息

上下游产品

4-bromo-2,6-diethyIpyridine 1-oxide 2,6-diethylpyridin-4-ol acetonedicarboxylic acid propionic acid anhydride 2,6-Diethyl-4-cyanopyridin

合成工艺路线路线简述

  • 1115035-61-4 = 877133-54-5
    反应条件:1.1 Reagents: Pentabromophosphorane Solvents: Chloroform; 1 H,60 °C1.2 8 H,120 °C; Cooled1.3 Reagents: Sodium Hydroxide Solvents: Water
    标题:Discovery Of (R)-6-Cyclopentyl-6-(2-(2,6-Diethylpyridin-4-Yl)Ethyl)-3-((5,7-Dimethyl-[1,2,4]Triazolo[1,5-A]Pyrimidin-2-Yl)Methyl)-4-Hydroxy-5,6-Dihydropyran-2-One (Pf-00868554) As A Potent And Orally Available Hepatitis C Virus Polymerase Inhibitor
    作者:Li,Hui; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(5) 页码:1255-1258]

    1035267-63-0 = 877133-54-5
    反应条件:1.1 Reagents: Phosphorus Tribromide Solvents: Dichloromethane
    标题:Synthetic Route Optimization Of Pf-00868554,An Hcv Polymerase Inhibitor In Clinical Evaluation
    作者:Johnson,Sarah; Et Al
    参考文献:Synlett 日期:2010 卷标:(5) 页码:796-800]

    1115035-61-4 = 877133-54-5
    反应条件:1.1 Reagents: Phosphoric Tribromide Solvents: Dimethylformamide; 120 °C
    标题:Synthetic Route Optimization Of Pf-00868554,An Hcv Polymerase Inhibitor In Clinical Evaluation
    作者:Johnson,Sarah; Et Al
    参考文献:Synlett 日期:2010 卷标:(5) 页码:796-800]

    1115035-61-4 = 877133-54-5
    反应条件:1.1 Reagents: Phosphoric Tribromide; 90 Min,130 °C
    标题:Di-Substituted Pyridinyl Aminohydantoins As Potent And Highly Selective Human β-Secretase (Bace1) Inhibitors
    作者:Malamas,Michael S.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2010 卷标:18(2) 页码:630-639]

    542-05-2 = 877133-54-5
    反应条件:1.1 Reagents: Sulfuric Acid; 100 °C1.2 Reagents: Acetic Acid,Sodium Bicarbonate Solvents: Water; 100 °C; 100 °C -> Rt1.3 Reagents: Chloroform; Reflux1.4 Reagents: Ammonia Solvents: Water; 50 °C1.5 Reagents: Pentabromophosphorane; 120 °C
    标题:A New Fluorogenic Small-Molecule Labeling Tool For Surface Diffusion Analysis And Advanced Fluorescence Imaging Of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Based On Silicone Rhodamine: Sir-Bace1
    作者:Karch,Sandra; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2018 卷标:61(14) 页码:6121-6139]

    542-05-2 = 877133-54-5
    反应条件:1.1 Reagents: Sulfuric Acid; 100 °C1.2 Reagents: Sodium Sulfate; 100 °C1.3 Reagents: Hydrochloric Acid; 100 °C1.4 Reagents: Ammonium Hydroxide; 50 °C2.1 Reagents: Phosphoric Tribromide Solvents: Dimethylformamide; 120 °C
    标题:Synthetic Route Optimization Of Pf-00868554,An Hcv Polymerase Inhibitor In Clinical Evaluation
    作者:Johnson,Sarah; Et Al
    参考文献:Synlett 日期:2010 卷标:(5) 页码:796-800]

    542-05-2 = 877133-54-5
    反应条件:1.1 Reagents: Sulfuric Acid1.2 Reagents: Acetic Acid,Sodium Carbonate1.3 Reagents: Hydrochloric Acid2.1 Reagents: Ammonium Hydroxide2.2 Reagents: Methyl Iodide,Lithium Diisopropylamide Solvents: Tetrahydrofuran3.1 Reagents: Phosphoric Tribromide; 90 Min,130 °C
    标题:Di-Substituted Pyridinyl Aminohydantoins As Potent And Highly Selective Human β-Secretase (Bace1) Inhibitors
    作者:Malamas,Michael S.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2010 卷标:18(2) 页码:630-639]

    114960-28-0 = 877133-54-5
    反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid2.1 Reagents: Acetyl Bromide Solvents: Acetic Acid3.1 Reagents: Phosphorus Tribromide Solvents: Dichloromethane
    标题:Synthetic Route Optimization Of Pf-00868554,An Hcv Polymerase Inhibitor In Clinical Evaluation
    作者:Johnson,Sarah; Et Al
    参考文献:Synlett 日期:2010 卷标:(5) 页码:796-800]

    14774-14-2 = 877133-54-5
    反应条件:1.1 Reagents: Ammonium Hydroxide1.2 Reagents: Methyl Iodide,Lithium Diisopropylamide Solvents: Tetrahydrofuran2.1 Reagents: Phosphoric Tribromide; 90 Min,130 °C
    标题:Di-Substituted Pyridinyl Aminohydantoins As Potent And Highly Selective Human β-Secretase (Bace1) Inhibitors
    作者:Malamas,Michael S.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2010 卷标:18(2) 页码:630-639]

    14774-14-2 = 877133-54-5
    反应条件:1.1 Reagents: Ammonia Solvents: Water; Overnight,50 °C; 50 °C -> Rt2.1 Reagents: Pentabromophosphorane Solvents: Chloroform; 1 H,60 °C2.2 8 H,120 °C; Cooled2.3 Reagents: Sodium Hydroxide Solvents: Water
    标题:Discovery Of (R)-6-Cyclopentyl-6-(2-(2,6-Diethylpyridin-4-Yl)Ethyl)-3-((5,7-Dimethyl-[1,2,4]Triazolo[1,5-A]Pyrimidin-2-Yl)Methyl)-4-Hydroxy-5,6-Dihydropyran-2-One (Pf-00868554) As A Potent And Orally Available Hepatitis C Virus Polymerase Inhibitor
    作者:Li,Hui; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(5) 页码:1255-1258]

    457919-59-4 = 877133-54-5
    反应条件:1.1 Reagents: Acetyl Bromide Solvents: Acetic Acid2.1 Reagents: Phosphorus Tribromide Solvents: Dichloromethane
    标题:Synthetic Route Optimization Of Pf-00868554,An Hcv Polymerase Inhibitor In Clinical Evaluation
    作者:Johnson,Sarah; Et Al
    参考文献:Synlett 日期:2010 卷标:(5) 页码:796-800]

    935-28-4 = 877133-54-5
    反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Solvents: Chloroform2.1 Reagents: Sulfuric Acid,Nitric Acid3.1 Reagents: Acetyl Bromide Solvents: Acetic Acid4.1 Reagents: Phosphorus Tribromide Solvents: Dichloromethane
    标题:Synthetic Route Optimization Of Pf-00868554,An Hcv Polymerase Inhibitor In Clinical Evaluation
    作者:Johnson,Sarah; Et Al
    参考文献:Synlett 日期:2010 卷标:(5) 页码:796-800]

    2402-78-0 + 925-90-6 = 877133-54-5
    反应条件:1.1 Catalysts: Dichloro[1,1′-(1,3-Propanediyl)Bis[1,1-Diphenylphosphine-Kp]]Nickel Solvents: Diethyl Ether2.1 Reagents: M-Chloroperbenzoic Acid Solvents: Chloroform3.1 Reagents: Sulfuric Acid,Nitric Acid4.1 Reagents: Acetyl Bromide Solvents: Acetic Acid5.1 Reagents: Phosphorus Tribromide Solvents: Dichloromethane
    标题:Synthetic Route Optimization Of Pf-00868554,An Hcv Polymerase Inhibitor In Clinical Evaluation
    作者:Johnson,Sarah; Et Al
    参考文献:Synlett 日期:2010 卷标:(5) 页码:796-800
📜4-Bromo-2,6-Diethyipyridine 1-Oxide置于三溴化磷体系中,用 二氯甲烷 作为反应溶剂,以64%的收率获得产物4-溴-2,6-二乙基吡啶
参考文献:Synthetic Route Optimization Of Pf-00868554,An Hcv Polymerase Inhibitor In Clinical Evaluation
标题:Synthetic Route Optimization Of Pf-00868554,An Hcv Polymerase Inhibitor In Clinical Evaluation
摘要:本文介绍了为提供多克级 Pf-00868554 而进行的优化工作,Pf-00868554 是一种 Hcv 聚合酶抑制剂,目前正处于二期临床评估阶段.
DOI:10.1055/s-0029-1219352

海关参考信息

专利信息


专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

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合成参考文献


参考文献:10.1055/s-0029-1219352
摘要:Li H, Johnson S, Drowns M, Tatlock J, Linton A, Gonzalez J, Hoffman R, Jewell T, Patel L, Blazel J, Tang M. Synthetic Route Optimization of PF-00868554, An HCV Polymerase Inhibitor in Clinical Evaluation. Synlett. 2010 Jan 25;2010(05):796–800. doi: 10.1055/s-0029-1219352.
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