专利号:US-2025026643-A1 优先权日:2021-12-03 标题 :Production of anhydrous quaternary ammonium hydroxides 发明人:ZHOU HUI; ZHANG KE 权利人:HUNTSMAN PETROCHEMICAL LLC 摘要:A method for the synthesis of anhydrous quaternary ammonium hydroxides having the formula (NR 1 R 2 R 3 R 4 ) OH, wherein R 1 , R 2 , R 3 and R 4 are the same as or different from one another and are each individually selected from H, C 1 -C 10 alkyls including linear or cyclo alkyls, and C 6 -C 12 aryls by reacting an alkylene oxide with a tertiary amine having the formula R 1 R 2 R 3 N wherein R 1 , R 2 , and R 3 are the same or different and are each individually selected from C 1 -C 10 alkyls including linear and cyclo alkyls, C 1 -C 10 hydroxyalkyls, C 6 -C 12 aryls, and formulations having anhydrous quaternary ammonium hydroxides.
专利号:US-2024287084-A1 优先权日:2021-10-28 标 题 :Synthesis of [1,2,3]triazolo[4,5-d]pyrimidines 发明人:ADAM JEAN-MICHEL; GRETHER UWE; MOESSNER CHRISTIAN; TOSATTI PAOLO 权利人:HOFFMANN LA ROCHE 摘要:The present invention relates to a process for the preparation of [1,2,3]triazolo[4,5-d]pyrimidine derivatives useful as pharmaceutically active compounds, in particular 1-[5-tert-butyl-3-[(1-methyltetrazol-5-yl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol.
专利号:WO-2011148392-A1 优先权日:2010-05-28 标题 :Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof 发明人:SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY 权利人:MSN LAB LTD; SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY 摘要:The present invention relates to a process for the preparation of (2S,4S,5S,7S)-N-(2- Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxy propoxy )phenyl]-octanamide compound of formula- 1 and its pharmaceutically acceptable salts thereof. Further, relates to the processes for the preparation of (R)-4-(2-(halomethyl)-3- methylbutyl)-l-methoxy-2-(3-methoxypropoxy) benzene and (R)-2-(4-methoxy-3-(3-methoxy propoxy) benzyl)-3-methyIbutan-l-ol useful intermediates in the synthesis of compound of formula- 1.
专利号:WO-8503665-A1 优先权日:1984-02-15 标题:Synthesis of polyurethane products 发明人:HOSTETTLER FRITZ 权利人:PIRRI JAQUELYN P; HOSTETTLER FRITZ 摘要:Wide range of polyurethane products, e.g., cellular, dense elastomer, and integral skin microcellular products, obtained by the reaction of (a) a polyisocyanate compound, (b) a polyol, (c) optionally a chain extender and/or blowing agent with/without other known additives, (d) in the presence of a nonhydroxyl flow modifier characterized by carbon and hydrogen atoms, at least one and, generally, a plurality of oxyalkylene groups, and at least one urethane, $(1,5)omicronp. Several of the polyurethane products exhibit unique properties, e.g., foamed articles with capability to conduct static electricity, soft elastomers characterized by improved coefficient of friction, etc. Several classes of the flow modifiers are novel per se. The polyurethane products can be synthesized via the one shot or prepolymer process. Multipackage systems, in particular, two and three component systems are useful in molding operations, e.g., manufacture of shoe soles.
专利号:US-8168556-B2 优先权日:2007-10-25 标 题 :Racemoselective synthesis of ansa-metallocene compounds, ansa-metallocene compounds, catalysts comprising them, process for producing an olefin polymer by use of the catalysts, and olefin homo- and copolymers 发明人:SCHULTE JOERG; SELL THORSTEN; THORN MATTHEW GRANT; WINTER ANDREAS; DIMESKA ANITA 权利人:SCHULTE JOERG; SELL THORSTEN; THORN MATTHEW GRANT; WINTER ANDREAS; DIMESKA ANITA; LUMMUS NOVOLEN TECHNOLOGY GMBH 摘要:A metallocene compound with the 4- and 7-positions on the indenyl moiety possessing large aromatic substituents is prepared in accordance with a method which produces substantially 100 percent racemic isomer. Advantageously, polymerization catalysts including the metallocene of the invention provide superior olefin polymerization results.
专利号:US-2016122450-A1 优先权日:2013-05-08 标题:Synthesis of a substituted furan 发明人:ZHANG YUGEN; TEONG SIEW PING; YI GUANGSHUN 权利人:AGENCY SCIENCE TECH & RES 摘要:The present invention provides a polymer comprising an aliphatic backbone having a plurality of aromatic rings bonded thereon, said plurality of aromatic rings comprising a first aromatic ring type that has an alkyl halide group substitution on the aromatic ring and a second aromatic ring type that has an optionally substituted ammonium halide group substitution on the aromatic ring. The present invention also provides a method for making an optionally substituted furan, the method comprising the step of subjecting a sugar to a dehydration reaction in the presence of a catalyst comprising said polymer.
参考标题:Synthesis Of Novel Intermediate(S) For Preparing Rivastigmine 摘要:The Present Invention Relates To Novel Intermediate(S), Which Are Useful For The Preparation Of Rivastigmine Compound Of Formula (I) And Its Pharmaceutically Acceptable Salts. The Present Invention Further Relates To The Processes For The Preparation Of Such Novel Intermediate(S) And Preparation Of Rivastigmine Using Such Novel Intermediate(S).
合成参考文献
摘要:Margaretha, P., Science of Synthesis Knowledge Updates, (2010) 4, 411. 摘要:Claver, C.; Peñafiel, I.; Urrutigoïty, M.; Kalck, P., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2018) 2, 318. 摘要:Li, H.; Wang, Y.; Liu, Q., Science of Synthesis: Base-Metal Catalysis, (2023) 2, 555.