CAS: 76757-90-9; Boc-D-Tyr-Ome

相似化合物

1080-06-4 3417-91-2 4326-36-7

上下游产品

tert-butyl dicarbonatedi-tert-butyl dicarbonate D-tyrosine methyl ester D-tyrosine methylester hydr°Chloride tyrosine(R)-2-tert-Butoxycarbonylamino-3-(4-ethoxy-phenyl)-propionic acid methyl ester B°C-D-Tyr(i-Pr) B°C-D-Tyr(n-Pr) (R)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid

L-酪氨酸置于氯化亚砜,三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 66.5H,反应生成 丁氧羰基-D-酪氨酸-甲氧基酯
参考文献: Novel Prodrugs And Combinations For Treatment Of Hypertension And Cardiovascular Diseases[fr] Nouveaux Pro-Médicaments Et Combinaisons Pour Le Traitement De L'Hypertension Et De Maladies Cardiovasculaires
标题: Novel Prodrugs And Combinations For Treatment Of Hypertension And Cardiovascular Diseases[fr] Nouveaux Pro-Médicaments Et Combinaisons Pour Le Traitement De L'Hypertension Et De Maladies Cardiovasculaires
摘要:该发明涉及一种药物组合物,包括(i)nep抑制剂的前药,(II)at1受体拮抗剂和nep抑制剂的相互前药,(iii)at1受体拮抗剂前药和nep抑制剂的组合,以及(iv)包括at1受体拮抗剂前药,Nep抑制剂前药和利尿药的组合,(v)包括at1受体拮抗剂,Nep抑制剂前药和钙通道阻滞剂的组合.at1受体拮抗剂选自阿利沙坦,依利沙坦,坎地沙坦,依普沙坦,厄贝沙坦,洛卡特普,沙普利沙坦,他索坦,替米沙坦和缬沙坦等组中选择的组.该发明还包括一种治疗高血压,心力衰竭(急性和慢性)充血性心力衰竭,左心室功能障碍和肥厚型心肌病,糖尿病性心肌病,心房和心室心律失常,心房颤动,心房扑动,有害的血管重塑,心肌梗死及其后遗症,动脉粥样硬化,心绞痛(无论不稳定还是稳定),肾功能不全(糖尿病和非糖尿病),心力衰竭,心绞痛,糖尿病,继发性醛固酮分泌亢进,原发性和继发性肺动脉高压,肾功能衰竭病情,如糖尿病性肾病,肾小球肾炎,硬皮病,肾小球硬化,原发性肾脏疾病的蛋白尿,以及肾脏血管性高血压,糖尿病视网膜病变,其他血管疾病的管理,如偏头痛,周围血管疾病,雷诺病,管腔内增生,认知功能障碍(如阿尔茨海默病),青光眼和中风的方法.

专利信息

专利号:US-2014309424-A1
优先权日:2011-06-30
标题:Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f] fluoromethyl) tyrosine
发明人：BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN
权利人:BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN; PIRAMAL IMAGING SA
摘要:The invention describes novel direct synthesis methods for converting a precursor into a PET-tracer with a 18 F-fluoromethoxy-group. The invention is also directed to novel and stable precursors for the direct radiosynthesis of protected derivatives of O—([ 18 F]Fluoromethyl)tyrosines.

专利号:US-9242927-B2
优先权日:2008-09-24
标题 :Process for the manufacture of N-acylbiphenyl alanine
发明人：ZHU GUOLIANG; SHI DESONG; WEI JUNHUI; TAO FENGFENG
权利人:ZHU GUOLIANG; SHI DESONG; WEI JUNHUI; TAO FENGFENG; ZHEJIANG JIUZHOU PHARM CO LTD; NOVARTIS AG
摘要:The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.

专利号:US-9181175-B2
优先权日:2009-01-13
标 题:Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid
发明人：ZHU GUOLIANG; YANG LIJUN; LIN YING; YING JIE
权利人:ZHU GUOLIANG; YANG LIJUN; LIN YING; YING JIE; ZHEJIANG JIUZHOUS PHARMACEUTICAL CO LTD
摘要:The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.

专利号:CN-118109528-A
优先权日:2024-04-10
标题 :A method for biocatalytic synthesis of sacubitril intermediate (2R, 4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylvaleric acid

专利号:CN-118516422-A
优先权日:2024-04-10
标 题:A method for biocatalytic synthesis of sacubitril intermediates

专利号:CN-117736117-A
优先权日:2023-11-13
标题:A kind of synthesis method of sacubitril drug intermediate