CAS: 7521-41-7; 2-Aminonicotinaldehyde

上下游产品

pyridine-3-carbonitrile 3-cyano-1-methylpyridinium iodide N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide 2-(3-Iminomethyl-pyridin-2-yl)-isoindole-1,3-dione 2-(3-pyridyl)-1,8-naphthyridine (2-Hydroxy-phenyl)-(2-phenyl-[1,8]naphthyridin-3-yl)-methanone 2-(2-hydroxyphenyl)-1,8-naphthyridine 2-Methyl-[1,8]naphthyridine-3-carboxylic acid (2-methoxy-phenyl)-amide

烟酰胺置于盐酸,氨基磺酸铵体系中,用 水 作为反应溶剂,化学反应 16.0H,反应生成 2-氨基-3-吡啶甲醛
参考文献:2-氨基烟碱醛及其金属配合物的合成,表征,生物学筛选和分子对接研究
标题:2-氨基烟碱醛及其金属配合物的合成,表征,生物学筛选和分子对接研究
摘要:配位体的邻氨基醛醛家族的生物学和光学重要性激发了我们评估2-氨基烟碱醛(ana)的配位性能和生物学活性的想法.在这里,我们使用各种分析和光谱技术报告了ana及其金属配合物ni(II),Pd(II),Co(II)和cu(II)的合成,表征,生物学筛选和分子对接研究.ana的单晶x射线衍射研究通过经典的n-h...o / N分子间/分子间和非经典的c-h...o解释了固态组装和有趣的超分子鲱鱼骨堆积模式/ N分子间氢键.筛选ana及其金属配合物的体外抗癌,抗微生物和抗氧化活性.测试了抗hela,Mcf-7和hek293人癌细胞系的抗癌活性.2 Cl 2]配合物对hela和mcf-7,[pd(ana)2 Cl 2]和[cu(ana)2 Cl 2]配合物对hela以及[co(ana)2 Cl 2]具有非常好的活性.针对mcf-7的复合物.在抗菌筛选中,[co(ana)2 Cl 2]和[cu(ana)2
DOI:10.1007/s11164-017-3089-Y

专利信息

专利号:US-9834556-B2
优先权日:2014-03-24
标题 :Process of preparing 3-(3-(4-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-YL)pyridin-2-amine
发明人：BATES CRAIG; CHEN JIAN-XIE; MAO JIANMIN; REED DAVID P
权利人:ARQULE INC
摘要:The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine:

专利号:US-6262268-B1
优先权日:1999-11-10
标 题 :Process and intermediates to a tetrahydro-[1,8]-naphthyridine
发明人：PALUCKI MICHAEL; HUGHES DAVID L; YANG CHUNHUA; YASUDA NOBUYOSHI
权利人:MERCK & CO INC
摘要:A novel process is provided for the preparation of 3-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)-propylamine which is useful in the synthesis of alphav integrin receptor antagonists. Also provided are useful intermediates obtained from the process.

专利号:WO-2008022467-A1
优先权日:2006-08-25
标 题 :2-substituted azain doles and 2 substituted thienopyrroles, their precursors and novel processes for the preparation thereof
发明人：LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
权利人:LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
摘要:The present invention relates generally to processes for the chemical synthesis of azaindole and thienopyrrole compounds, in particular azaindole and thienopyrrole compounds that are substituted at the 2-position of the azaindole or thienopyrrole ring, and optionally at additional locations of the azaindole or thienopyrrole ring such as the 1- and/or 3-position, compounds prepared by such processes, and synthetic precursors of such processes. More particularly, the present invention relates to the preparation of 2- substituted azaindoles from an ortho-gem-dihalovinylaminopyridine or from an ortho- gem-dihalovinylaminopyridine N-oxide compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to the preparation of 2-substituted thienopyrroles from an ortho-gem-dihalovinylthiophene compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to processes for the production of ortho-gem- dihalovinylaminopyridines which are useful as starting materials in the production of 2- substituted azaindoles, and novel compounds prepared by the processes. The present invention also relates to processes for the production of ortho-gem-dihalovinylthiophenes which are useful as starting materials in the production of 2-substituted thienopyrroles, and novel compounds prepared by the processes. Formulae (V) and (VII).

专利号:US-6423845-B1
优先权日:1999-11-23
标题 :Process and intermediates to a tetrahydro-[1,8]- Naphthyridine
发明人：RIVERA NELO R; XIAO YI; YASUDA NOBUYOSHI
权利人:MERCK & CO INC
摘要:A novel process is provided for the preparation of 3-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)-propylamine which is useful in the synthesis of alphav integrin receptor antagonists. Also provided are useful intermediates obtained from the process.

专利号:WO-2005051904-A2
优先权日:2003-10-23
标题 :Novel processes for the synthesis of cyclopropyl compounds

专利号:US-9670230-B2
优先权日:2012-11-29
标题 :Heteroaryl compounds and methods of use thereof
发明人：CAMPBELL JOHN EMMERSON; JONES PHILIP
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.