CAS: 71-67-0; Bromosulfophthalein Sodium
该化合物是一种合成有机化合物,主要用作染料和生物标记,其特征为:硫磺二溴二苯丁烯结构上的磺酸和溴代二苯替代物,有助于其在水中的溶解性,以及吸收特定波长光的能力.该化合物看起来像一种深红至紫固体,在水中溶解,使其在各种应用中有用,包括医疗诊断,特别是在肝功能测试中.BSP因其能够被肝细胞吸收并随后排出薄膜,在评估肝功能方面的作用而著名.其化学结构允许其进行电离化,这可能会影响其颜色和吸收特性,取决于溶液的pH值.安全考虑包括潜在的毒性和适当处理的必要性,以及许多化学物质.
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
海关参考信息
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专利信息
专利号:US-4256727-A
优先权日:1978-09-18
标 题:Synthesis and use of diagnostic radio-pharmaceuticals comprising radioactive isotopes of bromine with dyes
发明人：TRIPLETT JOHN W; SMITH RANDALL B
权利人:UNIV KENTUCKY RES FOUND
摘要:A process for preparing bromine-containing dyes labelled with gamma-emitting isotopes of bromine, and the product thereof which is useful as an imaging agent for the hepato-biliary system, particularly in dynamic imaging methods. The dyes prepared are from the class of triarylmethane dyes, and also from the phthalein subclass of the class of xanthene dyes, and the labelling thereof is effected with 76Br, 77Br or 82Br. The process for preparing these dyes involves reacting the non-brominated dye precursor with either 76Br2, 77Br2 or 82Br2. This is a substitution type of reaction in which a ring hydrogen is substituted by either 76Br, 77Br or 82Br.
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主要参考文献
1. Consortium, I.T., Giacomini, K.M., Huang, S.M., et al. Membrane transporters in drug development. Nat. Rev. Drug Dis. 9(3), 215-236 (2010). 2. Izumi, S., Nozaki, Y., Komori, T., et al. Substrate-dependent inhibition of organic anion transporting polypeptide 1B1: Comparative analysis with prototypical probe substrates estradiol-17β-glucuronide, estrone-3-sulfate, and sulfobromophthalein. Drug Metab. Dispos. 41(10), 1859-1866 (2013). 3. Karlgren, M., Vildhede, A., Norinder, U., et al. Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): Influence of protein expression on drug-drug interactions. J. Med Chem. 55(10), 4740-4763 (2012). 4. Patik, I., Székely, V., Német, O., et al. Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of organic anion-transporting polypeptides, OATP1B1/1B3 and 2B1. Sci. Rep. 8(1), 2630 (2018). 5. Zhang, J., Zhang, M., Sun, B., et al. Hyperammonemia enhances the function and expression of P-glycoprotein and Mrp2 at the blood-brain barrier through NF-κB. J. Neurochem. 131(6), 791-802 (2014). 6. Matsson, P., Pedersen, J.M., Norinder, U., et al. Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs. Pharm Res. 26(8), 1816-1831 (2009). 7. Itoh, T., Itagaki, S., Sasaki, K., et al. Pharmacokinetic modulation of irinotecan metabolites by sulphobromophthalein in rats. J. Pharm. Pharmacol. 56(6), 809-812 (2004). 8. Oh, J.H., Park, S.E., Shim, C.K., et al. Biliary clearance of bromosulfophthalein in anesthetized and freely moving conscious rat. Biopharm. Drug. Dispos. 30(2), 94-98 (2009). 9. McGuire, J.C., Taylor, P., and Greene, L.A. A modified bromosulfalein assay for the quantitative estimation of protein. Anal. Biochem. 83(1), 75-81 (1977).合成参考文献
摘要:American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 36:44
参考文献:10.1023/a:1018838405987
摘要:Tokui T, Nakai D, Nakagomi R, Yawo H, Abe T, Sugiyama Y. Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2. Pharm Res. 1999 Jun;16(6):904–8. doi: 10.1023/a:1018838405987.
参考文献:10.1007/s002800050954
摘要:Vahrmeijer AL, van Dierendonck JH, Schutrups J, van de Velde CJ, Mulder GJ. Potentiation of the cytostatic effect of melphalan on colorectal cancer hepatic metastases by infusion of buthionine sulfoximine (BSO) in the rat: enhanced tumor glutathione depletion by infusion of BSO in the hepatic artery. Cancer Chemother Pharmacol. 1999;44(2):111–6. doi: 10.1007/s002800050954.
参考文献:10.1007/bf02231364|10.1007/bf02231377|10.1007/bf02231381
摘要:HIGHTOWER NC, BRODERS AC, HAINES RD, McKENNEY JF, SOMMER AW. Chronic ulcerative colitis. I. Diagnostic considerations. Am J Dig Dis. 1958 Oct;3(10):722–33. doi: 10.1007/bf02231364.
参考文献:10.1007/bf02232147
摘要:SEPULVEDA B, JINICH H, BASSOLS F, MUNOZ R. Amebiasis of the liver; diagnosis, prognosis, and treatment. Am J Dig Dis. 1959 Jan;4(1):43–64. doi: 10.1007/bf02232147.
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