CAS: 70362-47-9; 2,2',4,5-Tetrachlorobiphenyl
该化合物是其化学文摘社(CAS)编号70362-47-9所知道的PCB 48,是多氯联苯(PCB)家族的成员,该家族由一组由碳,氢和氯原子组成的合成有机化学品组成,多氯联苯的特征是其双苯结构,其中两个苯环由一个单一的联结连接,氯化程度不同.PCB 48具体具有多种氯分体,影响其物理和化学特性,如稳定性,溶解性和毒性.一般而言,多氯联苯因其水隐性质而闻名,使其在环境中具有持久性,能够在生物体内产生生物累积性.它们还因其电绝缘特性而得到承认,从而导致它们在许多国家由于环境和健康问题而被禁用之前广泛用于电气设备和其他工业用途.PCB 48与其他多氯联苯一样,可能对人类健康和生态系统构成危险,需要小心处理和处置.
- 英文名称2,2',4,5-Tetrachlorobiphenyl
- 中文名称2,2'4,5-四氯联苯
- IUPAC名称1,2,4-trichloro-5-(2-chlorophenyl)benzene
- 其它别名2,2',4,5-Tetrachlorobiphenyl; 2,4,5,2'-Tetrachlorobiphenyl; PCB 48
- CAS编号70362-47-9
- MFCD编号:MFCD00152836
- FDA UNII编号:3287671514
- 分子式:C12H6Cl4分子量:291.99
- 产品CID: 1697634
- 产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: XBTHILIDLBPRPM-UHFFFAOYSA-N
- 1S/C12H6Cl4/c13-9-4-2-1-3-7(9)8-5-11(15)12(16)6-10(8)14/h1-6H
- 计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0
MSDS等安全信息
- 危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website. - 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
上下游产品
2,2',4,4',5,5'-Hexachlorobiphenyl合成工艺路线路线简述
📜邻氯苯胺,三氯苯置于sodium Acetate,亚硝酸体系中,化学反应生成 2,2'4,5-四氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4
海关参考信息
- 2903911000-邻二氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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📌 第三方产品分析报告
合成参考文献
摘要:T14: Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
摘要:L4: ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for polychlorinated biphenyls. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L135: International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
摘要:T6: World Health Organization (1993). Environ Health Criteria 140: Polychlorniated Biphenyls and Terphenyls.
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