CAS: 6807-83-6; (2S,3R,4S,5S,6R)-2-(((6Ar,12Ar)-6A,12A-Dihydro-6H-[1,3]Dioxolo[4',5':5,6]Benzofuro[3,2-C]Chromen-3-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol

该化合物是一种裂变胶质,这意味着它由一种与糖分子相连的裂变素细胞组成,以其潜在的生物活动闻名,包括抗氧化特性,有助于消除生物系统中的自由基质.Trifolirhizin已经研究过它可能的健康惠益,包括防炎和保护心的效应.它存在于极地溶剂中,许多裂变胶胶胶质的典型特征就是这种溶解剂,其稳定性可能受到诸如pH和温度等因素的影响.该化合物的结构允许它与各种生物目标相互作用,使其对药理学研究感兴趣.然而,还需要进一步研究,以充分阐明其行动和潜在治疗应用的机制.与许多自然产品一样,提取和净化过程可以对其产量和生物活性产生重大影响.

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C&L通报

上下游产品

UDP-glucose (-)-maackiain uridine-5'-diphosphoglucose trifolirhizin 6''-O-malonatetrifolirhizin tetraacetate

合成工艺路线路线简述

    📜尿苷(5')二氢二磷酰(1)-Alpha-D-葡萄糖,高丽槐素置于glycosyltransferase From Carthamus Tinctorius (L.) (Honghua) Recombinant体系中,用 二甲基亚砜 作为反应溶剂,化学反应 12.0H,以2.9 Mg的收率获得产物三叶豆紫檀苷
    参考文献:Exploring The Catalytic Promiscuity Of A New Glycosyltransferase From Carthamus Tinctorius
    标题:Exploring The Catalytic Promiscuity Of A New Glycosyltransferase From Carthamus Tinctorius
    摘要:The Catalytic Promiscuity Of A New Glycosyltransferase (Ugt73Ae1) From Carthamus Tinctorius Was Explored. Ugt73Ae1 Showed The Capability To Glucosylate A Total Of 19 Structurally Diverse Types Of Acceptors And To Generate O-,S-,And N-Glycosides,Making It The First Reported Trifunctional Plant Glycosyltransferase. The Catalytic Reversibility And Regioselectivity Were Observed And Modeled In A One-Pot Reaction Transferring A Glucose Moiety From Icariin To Emodin. These Findings Demonstrate The Potential Versatility Of Ugt73Ae1 In The Glycosylation Of Bioactive Natural Products.
    DOI:10.1021/ol502380P

    专利信息


    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Wang Y, Fang Y. Trifolirhizin targets PTK6 to induce autophagy and exerts antitumor effects in nasopharyngeal carcinoma. Drug Dev Res. 2024 Nov;85(7):e70000. doi: 10.1002/ddr.70000. 10(14):e34250. doi: 10.1016/j.heliyon.2024.e34250.
    3: Huang J, Song D, Xu M, Gan K, Wang C, Chen L, Huang Q, Chen J, Su Y, Xu J, Zhao J, Liu Q. Trifolirhizin reduces osteoclast formation and prevents inflammatory osteolysis by inhibiting RANKL-induced activation of NF-κB and MAPK signaling pathways and ROS. Phytother Res. 2024 Sep;38(9):4650-4666. doi: 10.1002/ptr.8299. Epub 2024 Aug 4. 24(1):287. doi: 10.1186/s12906-024-04593-0.
    5: Swargiary A, Daimari M, Swargiary A, Biswas A, Brahma D, Singha H. Identification of phytocompounds as potent inhibitors of sodium/glucose cotransporter-2 leading to diabetes treatment. J Biomol Struct Dyn. 2024 Feb

    合成参考文献


    参考文献:10.1248/cpb.34.2094
    摘要:Ohmoto T, Aikawa R, Nikaido T, Sankawa U, Wu LJ, Ueno A, Fukushima S. Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by components of Sophora flavescens Aiton. Chem Pharm Bull (Tokyo). 1986 May;34(5):2094–9. doi: 10.1248/cpb.34.2094.
    参考文献:10.1007/bf02994750
    摘要:Park JA, Kim HJ, Jin C, Lee KT, Lee YS. A new pterocarpan, (-)-maackiain sulfate, from the roots of Sophora subprostrata. Arch Pharm Res. 2003 Dec;26(12):1009–13. doi: 10.1007/bf02994750.
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