CAS: 59711-96-5; Etimicin

📜,乙醛置于盐酸,三乙酰氧基硼氢化钠,哌啶体系中,用 水,二甲基亚砜 作为反应溶剂,化学反应 3.0H,反应生成 依替米星
参考文献:一种硫酸依替米星的制备方法
标题:一种硫酸依替米星的制备方法
摘要:本发明公开了一种硫酸依替米星的制备方法.本发明采用fmoc‑cl保护庆大霉素c1A的3,2',6',3"位氨基,经纯化,蒸干后得到四芴甲氧羰基庆大霉素c1A;然后在酸性条件下加入乙醛水溶液n‑乙基化,再采用三乙酰氧基硼氢化钠进行还原;最后加入哌啶/dmso溶液脱保护;反应液用大孔吸附树脂柱初步纯化后,再经弱酸性阳离子吸附树脂二次纯化,纯化的产物加入硫酸反应制得硫酸依替米星.该方法上保护基时选择性高,副反应少;整个反应过程,反应条件温和,操作简便,更易于工业化的生产;产物纯度高,收率高.

专利信息

专利号:WO-2022222249-A1
优先权日:2021-04-24
标 题:Method for obtaining 1-n-ethyl gentamicin c1a by using pipeline reaction hydrolysis
发明人：WANG BIN; JIANG YINGQING; YOU LAN; YUAN WENJUN; LI PEIPENG
权利人:WUXI JIYU SHANHE PHARMACEUTICAL CO LTD
摘要:Involved is a method for obtaining 1-N-ethyl gentamicin C1a by using hydrolysis in a pipeline reactor. The method comprises the following steps: 1) pumping an etimicin synthesis solution and a NaOH solution into a temporary storage tank to be hydrolyzed, and mixing to obtain a reaction mixed solution; 2) opening a pipeline reactor to enable the temperature of a pipeline to reach about 100°C; 3) pumping the reaction mixed solution in step 1) into the pipeline reactor, controlling the temperatures of the inlet and outlet of a first reaction pipeline (1) to be 95-100°C, controlling the temperatures of the inlet and outlet of a second reaction pipeline (2) to be 100-110°C, keeping the temperature of the solution at 100-105°C, and performing hydrolysis for 6 hours; 4) after the reaction is completed, opening the circulating water supply valve and the circulating water return valve of a clamping sleeve on the pipeline reactor (3), and cooling to be close to room temperature; and 5) pumping a hydrolyzed reaction solution into a hydrolysis storage tank from the pipeline reactor (3).

专利号:CN-117567226-A
优先权日:2023-11-15
标 题:Synthesis method of alpha-amino acid compound