CAS: 5470-66-6; 4-Nitro-2-Picoline N-Oxide

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碳酸甲丙酯置于硫酸,双氧水,硝酸,溶剂黄146体系中,化学反应 40.0H,反应生成 2-甲基-4-硝基吡啶-N-氧化物
参考文献:基于亚胺的铁络合物催化的ch键氧化反应:机理研究
标题:基于亚胺的铁络合物催化的ch键氧化反应:机理研究
摘要:制备,表征了一系列基于亚胺的非血红素铁(II)配合物(lx)2 Fe(otf)2,并用作ch氧化催化剂.配体lx(x = 1,2,3,和4)静置由2-Pycolyl胺和4-取代的-2-吡啶甲基醛自发缩合得到的三齿配体的亚胺.仅在乙腈溶液中以2:2:1的比例混合醛,胺和fe(otf)2时,即可快速,定量地形成络合物.(l1)2 Fe(otf)(clo 4)和(l 3)2 Fe(otf)2被报道,显示出低旋转的八面体铁中心,其配体以子午线的方式排列.1 H NMR分析表明固态结构和自旋态保留在溶液中.这些分析还表明存在胺-亚胺互变异构平衡.(lx)2 Fe(otf)2利用H2O 2有效催化烷基c-h键的氧化作为末端氧化剂.亚胺配体的电子性质的控制对氧化过程的效率和选择性只有很小的影响.进行了一项机理研究,提供了c-h氧化是基于金属的证据.反应在羟基碳上以立体保留的方式发生,并在叔碳氢键上
DOI:10.1021/acs.Inorgchem.5B01500

专利信息

专利号:US-5998451-A
优先权日:1987-10-19
标 题 :Substituted tetralins, chromans and related compounds in the treatment and related compounds in the treatment of asthma, arthritis and related diseases
发明人：EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S
权利人:PFIZER
摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compositions thereof, a method of treatment therewith, and to intermediates useful in the synthesis thereof.

专利号:EP-1875239-B1
优先权日:2005-04-27
标题 :A method for the preparation of imaging probes using click chemistry
发明人：KOLB HARTMUTH C; MOCHARLA VANI P; WALSH JOSEPH C
权利人:SIEMENS MEDICAL SOLUTIONS
摘要:The invention provides a method for identifying a candidate imaging probe, the method comprising: a) contacting a first library of candidate compounds with a target biomacromolecule, b) identifying a first member from the first library exhibiting affinity for the first binding site; c) contacting the first member identified from the first library affinity for the first binding site with the target biomacromolecule; d) contacting a second library of candidate compounds with the first member and the target biomacromolecule, e) reacting the complementary first functional group with the second functional group via a biomacromolecule induced click chemistry reaction to form the candidate imaging probe; f) isolating and identifying the candidate imaging probe; g) preparing the candidate imaging probe by chemical synthesis; and h) for imaging applications, converting the candidate imaging probe into an imaging probe.

专利号:CN-104610138-A
优先权日:2015-01-09
标题 :Synthesis of ethylenediaminetetraacetic acid probes for protein paramagnetic labeling

专利号:US-5084458-A
优先权日:1987-05-14
标 题 :Substituted 2-acylpyridine-β-(N)-hetaryl-hydrazones and medicaments containing the same
发明人：SCHAPER KLAUS-JUERGEN; SEYDEL JOACHIM K
权利人:SCHAPER KLAUS JUERGEN; SEYDEL JOACHIM K
摘要:PCT No. PCT/DE88/00289 Sec. 371 Date Mar. 7, 1989 Sec. 102(e) Date Mar. 7, 1989 PCT Filed May 14, 1988 PCT Pub. No. WO88/08842 PCT Pub. Date Nov. 17, 1988.Substituted 2-acylpyridine- alpha -(N)-hetarylhydrazones are described, which are suitable as active substances for the treatment of antimicrobial and in particular antimycobacterial diseases, as well as active substances for the treatment of malaria or malignant tumours. The compounds have a marked synergistic activity combined with inhibitors of folate synthase, dihydrofolic acid reductase, DNA-synthesis and RNA-synthesis.

专利号:US-2004180938-A1
优先权日:2001-07-03
标题 :Novel butadiene derivatives, process for preparation of the same and intermediates for the synthesis thereof
发明人：OHTANI AKIO; OGIKU TSUYOSHI; YAMADA YASUHIRO
摘要:A butadiene derivative having an excellent inhibitory activity on the PAI-1, which is represented by the general formula [I]: n n n wherein R 1 is a hydrogen atom or a lower alkyl group, R 2 is a lower alkyl group, R 3 is a lower alkoxy group, R 4 is a hydrogen atom or a lower alkyl group, R 5 is a lower alkyl group, or a pharmaceutically acceptable salt thereof, a process a process for preparing the same and an intermediate thereof.

专利号:EP-1403252-A1
优先权日:2001-07-03
标题 :Novel butadiene derivatives, process for preparation of the same and intermediates for the synthesis thereof