CAS: 50773-41-6; (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-(((2S,3R,4R,5S)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Oxy)-4-Hydroxy-6-(Hydroxymethyl)-2-(((4S,5'R,6Ar,6Bs,8As,8Br,9S,10R,11As,12As,12Bs)-5',6A,8A,9-Tetramethyl-1,3,3',4,4',5,5',6,6A,6B,6',7,8,8A,8B,9,11A,12,12A,12B-Icosahydrospiro[naphtho[2',1':4,5]Indeno[2,1-B]Furan-10,2'-Pyran]-4-yl)Oxy)Tetrahydro-2H-Pyran-3-yl)Oxy)-6-Methyltetrahydro-2H-Pyran-3,4,5-Triol
该化合物是一种天然的血清素,主要来自巴黎多氯素植物物种,以其传统医药用途著称;该化合物的特点是其复杂的甘醇结构,其中包括一种与多种糖糖糖有关的类固醇脊;多氯苯丙胺A展示了一系列生物活动,包括抗炎,抗癌和抗微生物特性,使其成为药理研究的课题;其行动机制往往涉及将聚性中毒引入癌症细胞和调节各种信号路径;此外,多氯丙酮A具有提高其他治疗剂生物利用率的潜力,但使用该物质的同时,还考虑到毒性和副作用,需要进一步研究,以充分了解其安全情况和治疗潜力;总体而言,多氟丙胺是天然产品和药理化学领域的一个重要化合物,凸显了植物衍生物质在药物发现中的重要性.
- 英文名称(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-(((2S,3R,4R,5S)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Oxy)-4-Hydroxy-6-(Hydroxymethyl)-2-(((4S,5'R,6Ar,6Bs,8As,8Br,9S,10R,11As,12As,12Bs)-5',6A,8A,9-Tetramethyl-1,3,3',4,4',5,5',6,6A,6B,6',7,8,8A,8B,9,11A,12,12A,12B-Icosahydrospiro[naphtho[2',1':4,5]Indeno[2,1-B]Furan-10,2'-Pyran]-4-yl)Oxy)Tetrahydro-2H-Pyran-3-yl)Oxy)-6-Methyltetrahydro-2H-Pyran-3,4,5-Triol
- 中文名称重楼皂苷I
- IUPAC名称(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-(((2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-4-hydroxy-6-(hydroxymethyl)-2-(((4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
- 其它别名Polyphyllin D ; Diosgenyl α-L-Rhamnopyranosyl-(1–2)-[β-L-Ara-Binofuranosyl-(1–4)-β-D-Glucopyranoside] ; Polyphyllin I
- CAS编号50773-41-6
- MFCD编号:MFCD12407435
- 分子式:C44H70O16
- 分子量:855.03
- 产品CID: 1496122
- 产品分类生物化工
物理性质
MSDS等安全信息
上下游产品
CAS号122089-71-8 2,3,4-tri-O-ace... | CAS号14144-06-0 地索苷； 延龄草苷； 延年草甙 | CAS号19057-67-1 薯蓣次苷A | CAS号512-04-9 薯蓣皂苷元合成工艺路线路线简述
Diosgenyl 4,6-O-Benzylidene-3-O-Pivaloyl-β-D-Glucopyranoside置于吡啶,Sodium Hydroxide,4 Angstroem Ms,三氟化硼乙醚,对甲苯磺酸体系中,用 四氢呋喃,甲醇,二氯甲烷,水 作为反应溶剂,化学反应 7.0H,反应生成 重楼皂苷i
参考文献:A Facile Synthetic Approach To A Group Of Structurally Typical Diosgenyl Saponins
标题:A Facile Synthetic Approach To A Group Of Structurally Typical Diosgenyl Saponins
摘要:A Facile Approach Was Developed For Synthesizing An Important Group Of Plant Diosgenyl Saponins,Three Members (Dioscin,Polyphyllin D,And Balanitin 7) With Promising Bioactivities Were Prepared. (C) 1998 Published By Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0040-4039(98)01354-9
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905310000-1,2-乙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-114807075-A
优先权日:2021-01-27
标题:Glycosyltransferase PpUGT73E5 and application thereof in synthesis of paris polyphylla saponin
专利号:CN-114480323-A
优先权日:2020-11-11
标 题:Avena Glycosyltransferase AsUGT73E1 and Its Application in the Synthesis of Steroidal Saponins
专利号:CN-114480322-A
优先权日:2020-11-11
标题 :Oat glycosyltransferase AsUGT73E5 and application thereof in synthesis of steroid saponin
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📌 第三方产品分析报告
合成参考文献
参考文献:10.1016/s0031-9422(00)81066-3
摘要:Ma JCN, Lau FW. Structure characterization of haemostatic diosgenin glycosides from paris polyphylia. Phytochemistry. 1985 Jan;24(7):1561–5. doi: 10.1016/s0031-9422(00)81066-3.
参考文献:10.1093/abbs/gmx033
摘要:Liu J, Zhang Y, Chen L, Yu F, Li X, Dan Tao, Zhao J, Zhou S. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Jun 01;49(6):479–86. doi: 10.1093/abbs/gmx033.
参考文献:10.1096/fj.202001499r
摘要:Zhou Y, Yang D, Chen H, Zheng C, Jiang H, Liu X, Huang X, Ye S, Song S, Jiang N, Zhao Z, Ma S, Ma J, Huang K, Chen C, Fan X, Gong Y, Wang X, Fan J, Liu R, Shentu Y. Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice. FASEB J. 2020 Dec;34(12):16414–31. doi: 10.1096/fj.202001499r.
参考文献:10.19540/j.cnki.cjcmm.20210824.704
摘要:Zhang T, Zhang L, Lu JF, Wen J, Xiong YL, Liu Y. [Mechanism of polyphyllin Ⅰ targeting EGFR to affect proliferation and apoptosis of human breast cancer cells]. Zhongguo Zhong Yao Za Zhi. 2022 Feb;47(3):721–9. doi: 10.19540/j.cnki.cjcmm.20210824.704.
参考文献:10.1016/j.jpba.2014.12.002
摘要:Zhu H, Zhu S, Shakya S, Mao Q, Ding C, Long M, Li S. Study on the pharmacokinetics profiles of Polyphyllin I and its bioavailability enhancement through co-administration with P-glycoprotein inhibitors by LC–MS/MS method. Journal of Pharmaceutical and Biomedical Analysis. 2015 Mar;107():119–24. doi: 10.1016/j.jpba.2014.12.002.
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