CAS: 500-42-5; N2-(4-Chlorophenyl)-1,3,5-Triazine-2,4-Diamine

该化合物是一种主要用作二氨基和抗血压剂的杂交有机化合物,其化学结构具有氯化三氮核心,通过肾管抑制促进钠和氯化排泄,有助于其药理活动.氯氮化物以其中度和长效作用著称,因此适合管理中度和中度水肿和高血压.该化合物表现出良好的生物利用率和可预测的药用植物,确保了治疗效果的连贯性.其行动机制与其他硫化物相似的二氨基相匹配,尽管在某些临床环境中它可能提供有利的副作用特征.氯氮化物的稳定性和溶性特性进一步支持其以口服剂量形式配制.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号106-47-8 对氯苯胺 | CAS号109-94-4 甲酸乙酯 | CAS号64-18-6 甲酸 | CAS号4022-81-5 1-(4-氯苯基)双胍盐酸盐 | CAS号5304-59-6 1-(4-氯苯基)双胍

合成工艺路线路线简述

    📜甲酸,Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成 氯拉扎尼
    参考文献:Clauder; Bulcsu,Magyar Kemiai Folyoirat,1951,Vol. 57,P. 68,71
    标题:Clauder; Bulcsu,Magyar Kemiai Folyoirat,1951,Vol. 57,P. 68,71

    海关参考信息

    专利信息


    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:US-2008287407-A1
    优先权日:2003-12-10
    标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
    发明人:GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
    权利人:NITROMED INC
    摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

    专利号:KR-101513003-B1
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications

    专利号:US-10814013-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A2
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A1
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Thevis M, Krug O, Geyer H, Walpurgis K, Baume N, Thomas A. Analytical challenges in sports drug testing. Anal Bioanal Chem. 2018 Mar;410(9):2275-2281. doi: 10.1007/s00216-018-0934-9. Epub 2018 Feb 14. doi: 10.1016/j.jpba.2015.07.017. Epub 2015 Jul 22. German. German. German. German. German. German. German.

    合成参考文献


    摘要:Archives Internationales de Pharmacodynamie et de Therapie., 151(225), 1964 []
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