CAS: 330645-87-9; 2-(6-Chloro-1H-Benzo[d][1,2,3]Triazol-1-yl)-1,1,3,3-Tetramethyluronium Hexafluorophosphate(V)

专利信息

专利号:WO-2024165450-A1
优先权日:2023-02-09
标题:Method of chemical synthesis of single-chain antibody fragments and products thereby obtained
发明人：FIGINI MARIANGELA; LUISON ELENA
权利人:GLYTECH INC; FIGINI MARIANGELA
摘要:A new method is disclosed for the protein full-chemical synthesis of single-chain antibody fragments (scFv); the obtained products are structurally close and functionally equivalent to their biological counterpart, being however, advantageously free of impurities and more reproducible in properties. The method includes the general steps of: (a) separately synthetizing sub-sequences (peptide fragments) (b) sequentially assembling the sub-sequences obtained in step (a) in the order as they appear in the target scFv amino acid sequence, and (c) performing oxidative folding of the assembled whole peptide molecule obtained in step (b) and dialyzing the resulting product in a buffer.

专利号:US-10858390-B2
优先权日:2016-09-02
标 题 :Use of excess carbodiimide for peptide synthesis at elevated temperatures
发明人：COLLINS JONATHAN M; SINGH SANDEEP K
权利人:CEM CORP
摘要:An improved method of coupling amino acids into peptides or peptidomimetics is disclosed in which the activation and coupling are carried out in the same vessel, in the presence of a carbodiimide in an amount greater than 1 equivalent as compared to the amino acid, in the presence of an activator additive, and at a temperature greater than 30° C.

专利号:US-8076332-B2
优先权日:2006-12-26
标 题:N- (2-aminophenyl) benzamide derivative having urea structure
发明人：MOGI HIROYUKI; TAJIMA HISASHI; MISHINA NORIKO; YAMAZAKI YUSUKE; YONEDA SHINJI; WATANABE KATSUHIKO; FUJIKAWA JUNKO; YAMAMOTO MINORU
权利人:MOGI HIROYUKI; TAJIMA HISASHI; MISHINA NORIKO; YAMAZAKI YUSUKE; YONEDA SHINJI; WATANABE KATSUHIKO; FUJIKAWA JUNKO; YAMAMOTO MINORU; SANTEN PHARMACEUTICAL CO LTD
摘要:The present invention relates to a study on the synthesis of a novel N-(2-aminophenyl)benzamide derivative having an urea structure and represented by the general formula (1); and the utilization of a pharmacological effect of the derivative. A compound represented by the general formula (1) or a salt thereof has an effect of cellular morphological change on trabecular meshwork cells and is effective in the prevention and/or treatment of a disease considered to be related to intraocular pressure. In the formula, R 1 and R 2 represent a hydrogen atom, a lower alkyl group, or the like; R 3 represents a hydroxy group, a lower alkoxy group, a lower cycloalkyloxy group, an aryloxy group, or the like; R 4 and R 5 represent a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, or the like; X represents a lower alkylene group or the like; Y represents a single bond, a lower alkylene group, or the like; l and m represent 0, 1, 2, or the like.

专利号:EP-4414386-A1
优先权日:2023-02-09
标题 :Method of chemical synthesis of single-chain antibody fragments and products thereby obtained

专利号:US-2018066013-A1
优先权日:2016-09-02
标 题 :Use of Excess Carbodiimide for Peptide Synthesis at Elevated Temperatures

专利号:EP-3290430-A1
优先权日:2016-09-02
标 题:Use of excess carbodiimide for peptide synthesis at elevated temperatures