CAS: 32890-94-1; 2-Fluoro-6-(Trifluoromethyl)Benzoic Acid

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CAS号109-72-8 正丁基锂 | CAS号401-80-9 间氟三氟甲苯 | CAS号401-80-9 间氟三氟甲苯

2-氟-6-(三氟甲基)苯甲醛置于potassium Permanganate体系中,用 水 用作溶剂,化学反应 1.0H,以88.4%的收率获得2-氟-6-(三氟甲基)苯甲酸
参考文献:2-氟-6-(三氟甲基)苯甲酰胺的制备方法
标题:2-氟-6-(三氟甲基)苯甲酰胺的制备方法
摘要:本发明提供了一种2‑氟‑6‑(三氟甲基)苯甲酰胺的制备方法,包括向2‑氟‑6‑(三氟甲基)苯甲酸的有机溶液中加入缚酸剂和氯化剂,将2‑氟‑6‑(三氟甲基)苯甲酸酰氯化后,再加入胺化剂,使2‑氟‑6‑(三氟甲基)苯甲酰氯酰胺化的步骤.本发明提供的2‑氟‑6‑(三氟甲基)苯甲酰胺的的制备方法步骤简单,质量上乘,收率高,纯度高,适宜于工业化生产.

专利信息

专利号:US-12227528-B2
优先权日:2017-11-09
标 题:Glucose-sensitive albumin-binding derivatives
发明人：KRUSE THOMAS; KOFOD-HANSEN MIKAEL; MUENZEL MARTIN WERNER BORCHSENIUS; THOEGERSEN HENNING; SAUERBERG PER; EWALD JAKOB; BEHRENS CARSTEN; HOEG-JENSEN THOMAS; BALSANEK VOJTECH; DROBNAKOVA ZUZANA; DROZ LADISLAV; HAVRANEK MIROSLAV; KOTEK VLADISLAV; STENGL MILAN; SNAJDR IVAN; DRUSANOVA HANA
权利人:NOVO NORDISK AS
摘要:This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

专利号:US-9168248-B2
优先权日:2009-02-17
标 题:Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
发明人：LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LI CHUN SING; MORADEI OSCAR MIGUEL
权利人:LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LI CHUN SING; MORADEI OSCAR MIGUEL; MERCK CANADA INC
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.