CAS: 288573-56-8; Tert-Butyl 4-((4-Fluorophenyl)Amino)Piperidine-1-Carboxylate

该化合物是一种化学化合物,其特点是管状环结构,有助于其基本性和形成氢联结的潜力;四氟联苯组的存在会增强其亲脂性,并可能影响其生物活动,使其对药物研究感兴趣;酯功能组表示,它可以进行水解,有可能释放相应的箱状酸和酒精;这种化合物可能具有特定的药理特性,包括可能作为止痛剂或抗炎剂的活动,因为存在结构型细胞,其溶解性和稳定性可能因环境条件而不同,例如pH和温度而不同;与许多有机化合物一样,安全性和处理预防措施至关重要,因为如果摄入或吸入,可能会构成风险.

英文名称Tert-Butyl 4-((4-Fluorophenyl)Amino)Piperidine-1-Carboxylate
中文名称1-Boc-4-(4-氟苯氨基)-哌啶
其它别名1-tert-Butoxycarbonyl-4-[(4-fluorophenyl)amino]piperidine; 4-(4-Fluorophenylamino)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(4-fluoroanilino)-1-piperidinecarboxylate
CAS编号288573-56-8
MFCD编号:MFCD07785990
FDA UNII编号:5PT28N6ELP
分子式:C16H23FN2O2分子量:294.36
产品CID: 1270030
产品分类有机原料 → 有机杂环化合物 → 哌啶类

相似结构搜索
InChIKey: TUYSUNKDSSHKHM-UHFFFAOYSA-N
InChI=1S/C16H23FN2O2/c1-16(2,3)21-15(20)19-10-8-14(9-11-19)18-13-6-4-12(17)5-7-13/h4-7,14,18H,8-11H2,1-3H3
计算化学: 氢键受体数4.0氢键供体数1.0可旋转键数4.0

MSDS等安全信息

上下游产品

1-Boc-4-氨基哌啶 1-(Tert-Butoxycarbonyl)-4-Aminopiperidine 87120-72-7

合成工艺路线路线简述

合成目标产物 1-Boc-4-(4-Fluoro-Phenylamino)-Piperidine 主要起始原料 N-(Tert-Butoxycarbonyl)-4-Piperidone And 4-Fluoroaniline
(文献来源)合成步骤主要原料 N-(Tert-Butoxycarbonyl)-4-Piperidone 和 4-Fluoroaniline

📜4-氟苯胺置于三乙酰氧基硼氢化钠体系中,用二氯甲烷用作溶剂,化学反应 18.5H,反应生成1-Boc-4-(4-氟苯氨基)-哌啶
参考文献:The Discovery Of [1-(4-Dimethylamino-Benzyl)-Piperidin-4-Yl]-[4-(3,3-Dimethylbutyl)-Phenyl]-(3-Methyl-But-2-Enyl)-Amine,An N-Type Ca +2 Channel Blocker With Oral Activity For Analgesia
标题:The Discovery Of [1-(4-Dimethylamino-Benzyl)-Piperidin-4-Yl]-[4-(3,3-Dimethylbutyl)-Phenyl]-(3-Methyl-But-2-Enyl)-Amine,An N-Type Ca +2 Channel Blocker With Oral Activity For Analgesia
摘要:Our Drug Discovery Efforts For N-Type Calcium Channel Blockers In The 4-Piperidinylaniline Series Led To The Discovery Of An Orally Active Analgesic Agent 26. 1-[4-Dimethylamino-Benzyl)-Piperidin-4-Yl]-[4-(3,3-Dimethyl-Butyl)-Phenyl]-(3-Methyl-But-2-Enyl)-Amine (26) Showed High Affinity To Functionally Block N-Type Calcium Channels Ic50 = 0.7 Mu M In The Imr32 Assay) And Exhibited High Efficacy In The Anti-Writhing Analgesia Test With Mice (Ed50 = 12 Mg/kg By Po And 4 Mg/kg By Iv). In This Report,The Rationale For The Design,Synthesis,Biological Evaluation,And Pharmacokinetics Of This Series Of Blockers Is Described. (C) 2000 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0968-0896(00)00077-8