CAS: 28315-93-7; 5-Hydroxy-3,4-Dihydronaphthalen-1(2H)-One

该化合物是属于四氟化合物类别的有机化合物,它们是双环化合物,具有一氯酮功能组,其特征是四氟酮结构的5个位置上存在一个氢氧化物组(OH),它一般看起来像白色到白色以外的固体,在乙醇和甲醇等有机溶剂中可溶解,但在水中溶解性有限.由于存在氢氧和碳基组,复合物表现出令人感兴趣的化学反应,允许各种化学变异,包括氧化和替代反应.5-Hydroxy-1-teroon由于其潜在的生物活动,包括反氟化和肛门特性,对医药化学和研究感兴趣.它的结构特征也使它在更复杂的有机分子合成中成为有价值的中间体.与许多有机化合物一样,在与该物质打交道时,应观察适当的处理和安全防范措施.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号83-56-7 1,5-二羟基萘 | CAS号33892-75-0 5-甲氧基-1-萘满酮 | CAS号40771-26-4 1,5-二羟基-1,2,3,4-四氢萘 | CAS号3041-17-6 4,5-二氢苯并[b]氧杂卓-... | CAS号529-34-0 1-四氢萘酮 | CAS号91028-13-6 acetic acid,5,6... | CAS号13913-82-1 十氢萘-1,5-二酮 | CAS号529-35-1 5,6,7,8-四氢-1-萘酚 | CAS号40771-26-4 1,5-二羟基-1,2,3,4-四氢萘 | CAS号27591-01-1 布诺洛尔 | CAS号74887-79-9 6-羟基-4,5-二氢-1H-... | CAS号140481-22-7 5,6-dihydro-4H-... | CAS号140244-74-2 6,7-dihydro-5H-... | CAS号6939-35-1 3,4-二氢化-5-甲基-1(... | CAS号432036-78-7 8-phenylmethoxy... | CAS号41552-12-9 5-hydroxy-6-nit... | CAS号41552-20-9 3,4-dihydro-6,8... | CAS号40771-27-5 3,4-dihydro-5-h...

合成工艺路线路线简述

  • 合成目标产物 5-Hydroxy-1-Tetralone 主要起始原料 1,5-Dihydroxy Naphthalene
  • (文献来源)合成步骤主要原料 1,5-Dihydroxy Naphthalene
四氢萘酚置于chromium(Vi) Oxide,硫酸,乙酸酐,溶剂黄146体系中,化学反应生成5-羟基-1-四氢萘酮
参考文献:Organic Analysis. Vii. New Fluorescence Reaction Of Hexose By 5-Hydroxytetralone
标题:Organic Analysis. Vii. New Fluorescence Reaction Of Hexose By 5-Hydroxytetralone
摘要:在硫酸中加热5-羟基四氢萘酮-(1)与含有己糖单位的己糖,低聚糖或多糖时,能够产生绿色荧光.该反应对己糖具有灵敏且特异的检测能力,仅受少数物质干扰.文中列出了己糖,低聚糖和多糖的检测限度,并描述了该试剂的新合成方法.
Doi:10.1248/cpb1953.4.209

海关参考信息

专利信息


专利号:WO-2008010578-A1
优先权日:2006-07-21
标题 :Process for production of styrene derivative
发明人:KUWABE SHIN-ITSU; MASAOKA HIDEO; GISELBRECHT KARL-HEINZ; HIEBL JOHANN; REITER KLAUS; SKRANC WOLFGANG; DE VRIES ANDRE HENDRIKUS MARIA; DE VRIES JOHANNES GERARDUS
权利人:ONO PHARMACEUTICAL CO; KUWABE SHIN-ITSU; MASAOKA HIDEO; GISELBRECHT KARL-HEINZ; HIEBL JOHANN; REITER KLAUS; SKRANC WOLFGANG; DE VRIES ANDRE HENDRIKUS MARIA; DE VRIES JOHANNES GERARDUS
摘要:A process for producing a styrene derivative represented by the general formula (III), particularly 5-(3-ethoxy- 3-oxopropyl)-7,8-dihydronaphthalen-1-yl pivalate with efficiency, comprising conducting a coupling reaction of a compound represented by the general formula (I) with a compound represented by the general formula (II) in a non-aqueous solvent in the presence of a catalytic amount of a phosphine complex of nickel or palladium, particularly a phosphine complex of nickel. The styrene derivative is useful as an intermediate for the synthesis of various pharmaceutical agents. (I)(II) (III) wherein each symbol is as defined in the description.

专利号:US-5426227-A
优先权日:1993-06-24
标 题:Enantioselective process for the preparation of leveobunolol
发明人:STAMPA DIEZ DEL CORRAL ALBERTO; CAMPS GARCIA PELAYO; ONRUBIA MIGUEL MARIA DEL CARME; ARNALOT AGUILAR CARMEN
权利人:MEDICHAM S A
摘要:The invention relates to a new, industrially advantageous, process for the preparation of the known beta-adrenergic blocking agent, levobunolol, not requiring resolution of racemic bunolol, based on the enantioselective synthesis of an oxiranic intermediate which is then reacted with tert-butylamine. It consists of reacting 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone with (R)-(-)epichlorhydrine in an aprotic solvent, in the presence of a strong base at a temperature of over 90° C., thus obtaining the intermediate chiral oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1-(2H)-naphthalenone with more than 95% optical purity, and then, the intermediate chiral oxirane is reacted with tert-butylamine.

专利号:US-7361789-B1
优先权日:2004-07-28
标 题 :Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis
发明人:YAN QI; ORIHUELA CARLOS; SHEN BO; CHEN YING; WANG XIN; NG JOHN; JI RUIZHI; ZHOU PENGZU
权利人:AMGEN INC
摘要:The present invention relates to novel dihydronaphthalene compounds, compositions, methods for using the same, and processes for preparing the same. The present invention also relates to novel total synthesis approaches for preparing these compounds. In addition, the present invention relates to methods of producing quantities of isomers of these compounds and separating and purifying them using chiral separation techniques. The present invention also relates to methods of producing quantities of a single isometric compound without the need for chiral separation techniques.

专利号:US-5504104-A
优先权日:1993-11-19
标 题:Tricyclic pyrone derivatives as protease inhibitors and antiviral agents
发明人:ELLSWORTH EDMUND L; TAIT BRADLEY D
权利人:WARNER LAMBERT CO
摘要:The present invention relates to novel substituted tricyclic pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The tricyclic pyrone derivatives are useful in the development of therapies for the treatment of vital infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized tricyclic pyrones and of related structures.

专利号:CN-104276934-A
优先权日:2014-09-26
标题:The chemical synthesis method of 4,8-dihydroxy-1-tetralone
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主要参考文献

参考标题:Efficient Synthesis Of Substances Related To Cinacalcet Hydrochloride Via Heck Coupling
作者:Fan Lei,Boyi Qu,Xiaolong Li,Li Guo,Mei Guan,Li Hai,Hui Jin,Yong Wu |发布日期:2014.10.2
摘要:Abstract Efficient Synthetic Methods To Process Substances Related To Cinacalcet Hydrochloride 1, Generated During The Preparation, Were Described. The Compounds Were Identified As [1-(7,8-Dihydro-Naphthalen-1-Yl)-Ethyl]-[3-(3-Trifluoromethyl-Phenyl)-Propyl]-Amine Hydrochloride 2,[1-(5,6,7,8-Tetrahydro-Naphthalen-1-Yl)-Ethyl]-[3-(3-Trifluoromethyl-Phenyl)-Propyl]-Amine Hydrochloride 3 And [1-(Naph

合成参考文献


参考文献:10.1371/journal.pone.0021922
摘要:Hunt PR, Son TG, Wilson MA, Yu Q, Wood WH, Zhang Y, Becker KG, Greig NH, Mattson MP, Camandola S, Wolkow CA. Extension of Lifespan in C. elegans by Naphthoquinones That Act through Stress Hormesis Mechanisms. PLoS ONE. 2011 Jul 13;6(7):e21922. doi: 10.1371/journal.pone.0021922.
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