CAS: 252663-47-1; (4-(Benzylcarbamoyl)Phenyl)Boronic Acid

上下游产品

4-(苯甲基氨酰基)苯硼酸频哪酯 N-Benzyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Benzamide 1073353-57-7
4-羧基苯硼酸 4-Carboxyphenylboronic Acid 14047-29-1

📜4-(苯甲基氨酰基)苯硼酸频哪酯置于盐酸,Sodium Periodate体系中,用 四氢呋喃,水 用作溶剂,化学反应生成4-(N-苄基甲酰氨)苯基硼酸
参考文献:芳基硼酸作为双作用faah和trpv1配体
标题:芳基硼酸作为双作用faah和trpv1配体
摘要:制备了一系列基于药效团模型设计的31种芳基硼酸,用于各种trpv1拮抗剂,并在faah和trpv1通道上进行了测试.其中四个化合物,即化合物3C,4A,5A,B充当双重faah / Trpv1阻滞剂,Ic 50值在0.56至8.11μm之间,而其他十种化合物(化合物1C,F-I,2C-F,4B)则抑制faah和激活/脱敏的trpv1.
Doi:10.1016/j.Bmcl.2016.01.071

专利信息

专利号:US-6919382-B2
优先权日:2000-08-31
标 题 :Preparation and uses of conjugated solid supports for boronic acids
发明人：HALL DENNIS G
权利人:UNIV ALBERTA
摘要:The invention provides novel solid supports comprising dihydroxyalkyl aminoalkyl and dihydroxyalkylaminobenzyl groups, and methods for making and using them. The supports are particularly useful for immobilizing and derivatizing functionalized boronic acids for use in solid phase synthesis, such as those used in combinatorial chemistries. The compositions and methods of the invention are also useful as scavenger solid supports, e.g., in solution-phase parallel synthesis of small molecule libraries, and for use in resin-to-resin transfer reactions via phase transfer of solid supported boronic acids under both aqueous and anhydrous conditions. The methods of the invention provide convergent solid-phase synthesis of symmetrically or unsymmetrically functionalized compounds, such as biphenyl compounds. Also provided are synthesizer devices, e.g., semiautomated parallel synthesizers.