CAS: 24654-55-5; 4-Fluorocinnamaldehyde

该化合物其结构特征为该化合物其结构特征为:有全氟苯基替代成分的丙烯基(一种不饱和的甲醚),该化合物一般是一种无色的黄色液体或固态,视其纯度和温度而定,其颜色为黄色液体或固态;其含氟苯基组的存在,具有独特的芳香味;苯环的副位置中的氟原子,可影响该化合物的再活性和极性,使其对各种化学反应感兴趣,包括核循环添加和凝聚反应. 3-(4-氟联苯基)-2-丙烯酸经常用于有机合成,可用作制药,农业化学品和其他精密化学品的生产中间体;其特性,如沸点,熔点和溶解性等,可因环境条件而异,并可影响该化合物的再反应和极度,从而引起人们对各种化学反应感兴趣,在使用其他功能组时,安全.

结构式图片

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CAS号63416-70-6 3-(4-氟苯基)丙醛

合成工艺路线路线简述

    1-氟-4-(丙-1-烯基)苯置于叔丁基过氧化氢,Ru(Tpttp)Cl2体系中,用 乙腈 用作溶剂,化学反应 3.0H,以76%的收率获得对氟肉桂醛
    参考文献:Evolution Of Physical And Photocatalytic Properties Of New Zn(II) And Ru(II) Complexes
    标题:Evolution Of Physical And Photocatalytic Properties Of New Zn(II) And Ru(II) Complexes
    摘要:Synthesis Of Zn(II) And Ru(II) Complexes Were Reported By Using N-4-Macrocyclic Schiff Base Ligands Under Solvothermal Conditions. The Newly Synthesized Zn(II) And Ru(II) Complexes Have Been Characterized By Various Physico-Chemical Techniques Such As Elemental Analysis,Molar Conductance,Hrms,Tga,Fesem,Uv-Vis,Ft-Ir,H-1 NMR,And Cyclic Voltammetry. By Using Molar Conductance Studies,The Complexes Are Formulated As [zn(Tpttp)]Cl-2 And [ru(Tpttp)Cl-2]. C-H Bond Activation Of An Sp A Group Of Methylstyrenes (Converted Into Cinnamaldehydes) And C-H Bond Activation Of The Sp(2) Bond Of Polycyclic Aromatic Hydrocarbons Through Photooxidation Was Examined In The Presence Of Zn(II) And Ru(II) Complexes. Reusable Activity Studies And Photostability Of Catalyst Are Investigated By Using Uv-Vis Spectra. Based On The Results,Higher Catalytic Activity Of [ru(Tpttp)Cl-2] Complex Than [zn(Tpttp)]Cl-2 Complex In Both C-H Bond Activation And Photooxidation Of Aromatic Hydrocarbons Has Been Reported. (C) 2019 Elsevier Ltd. All Rights Reserved.
    Doi:10.1016/j.Poly.2019.05.065

    海关参考信息

    专利信息


    专利号:US-9085605-B2
    优先权日:2010-05-27
    标 题:Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate
    发明人:LIU GANG; ZHAO NAN; MA YAO
    权利人:LIU GANG; ZHAO NAN; MA YAO; SHENZHEN SALUBRIS PHARM CO LTD
    摘要:The present invention discloses chemical synthesis, anti-tumor and anti-metastatic effects of a dual functional conjugate as shown by formula I. Specifically, paclitaxel or docetaxol is linked with muramyl dipeptide derivative to form a conjugate, thus dual anti-tumor and anti-metastatic effects are achieved by combination of chemotherapy and immunotherapy. The present invention also discloses that paclitaxel or docetaxol and muramyl dipeptide derivative conjugate is synthesized by combination of solid-phase and solution-phase synthesis, and said conjugate can be used in manufacture of anti-tumor medicaments as proved by reliable bioassays.

    专利号:US-10829464-B2
    优先权日:2016-11-23
    标题 :Benzoheterocyclic alkylamine compounds and use thereof
    发明人:LI JIAN; LAN LEFU; LI BAOLI; CHEN FEIFEI; NI SHUAISHUAI; LIU YIFU; WEI HANWEN; MAO FEI; ZHU JIN
    权利人:UNIV EAST CHINA SCIENCE & TECH; SHANGHAI INST MATERIA MEDICA CAS
    摘要:Disclosed are benzoheterocyclic alkylamine compounds, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, and a preparation method thereof, and use of the same in the manufacture of an antibacterial drug as an inhibitor of staphyloxanthin synthesis in Staphylococcus aureus .

    专利号:EP-3239139-B1
    优先权日:2010-05-27
    标题 :Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate

    专利号:US-2013143826-A1
    优先权日:2010-05-27
    标 题 :Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate

    专利号:EP-2612857-B1
    优先权日:2010-05-27
    标 题:Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate

    专利号:UA-79448-C2
    优先权日:2002-02-06
    标题 :Derivatives of 3-aryl-2,5-dihydroxy-1,4-benzoquinone, method for synthesis and pharmaceutical composition
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    合成参考文献


    摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 75.
    摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 83.
    摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 307.
    摘要:González-Bello, C., Science of Synthesis Knowledge Updates, (2018) 3, 441.
    摘要:MacMillan, D. W. C.; Watson, A. J. B., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 356.
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