CAS: 2315-81-3; 3-Chloro-4-Hydroxybenzonitrile

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📜4-羟基苯甲腈置于ammonium Persulfate,N-氯代丁二酰亚胺,氧气,次甲基绿体系中,用 乙腈 用作溶剂,化学反应 24.0H,以42.6 Mg的收率获得3-氯-4-羟基苯甲腈
参考文献:有机染料的可见光光催化活化n-氯代琥珀酰亚胺氯化芳烃和杂芳烃
标题:有机染料的可见光光催化活化n-氯代琥珀酰亚胺氯化芳烃和杂芳烃
摘要:使用n-氯代琥珀酰亚胺(ncs)在可见光激活的条件下,以中等到极好的收率氯化多种芳烃和杂芳烃.对已知的有机染料光催化剂的筛选导致鉴定出亚甲基绿是与ncs一起使用的最有效的催化剂.根据其中描述的机理研究,推测该反应通过亚甲基绿在可见光光氧化还原途径下通过ncs的单电子氧化来进行.Ncs的光氧化作用放大了ncs氯原子的亲电性,从而提高了其作为氯化试剂与芳香族底物的反应性.
Doi:10.1016/j.Tet.2019.130498

专利信息

专利号:US-9550757-B2
优先权日:2010-03-05
标题:Nuclear transport modulators and uses thereof
发明人：SHACHAM SHARON; KAUFFMAN MICHAEL; SANDANAYAKA VINCENT P; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).