专利号:WO-2006101119-A1 优先权日:2005-03-22 标 题 :Collagen synthesis promoter 发明人:TACHIKAWA MASAMI; KARAKIDA FUMITO; KAWAKAMI ZENJI; MATSUURA DAISUKE; KANATANI HIROTOSHI 权利人:TSUMURA & CO; TACHIKAWA MASAMI; KARAKIDA FUMITO; KAWAKAMI ZENJI; MATSUURA DAISUKE; KANATANI HIROTOSHI 摘要:A collagen synthesis promoter capable of exhibiting a satisfactory collagen synthesis promoting activity and a high skin conditioning potency. There is provided a collagen synthesis promoter comprising as an active ingredient an extract from the fruit of myrobalan, and provided a collagen synthesis promoter comprising as an active ingredient one or two or more members selected from the group consisting of chebulagic acid, chebulinic acid, gallic acid and corilagin. The provided collagen synthesis promoter is suitable for use as a skin external preparation or skin quality improver; and can impart moistness and suppleness to the skin, can effect texture conditioning and can sustain the water retaining power of superficial skin.
专利号:US-12036300-B2 优先权日:2021-03-31 标题:Methods and compositions for improving skin 发明人:LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN 权利人:OREAL 摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.
1: Yang L, Liu Y, Zhang W, Hua Y, Chen B, Wu Q, Chen D, Liu S, Li X. Ferroptosis-Inhibitory Difference between Chebulagic Acid and Chebulinic Acid Indicates Beneficial Role of HHDP. Molecules. 2021 Jul 15;26(14):4300. doi: 10.3390/molecules26144300. 2: Vasu G, Sundaram R, Muthu K. Chebulagic acid attenuates HFD/streptozotocin induced impaired glucose metabolism and insulin resistance via up regulations of PPAR γ and GLUT 4 in type 2 diabetic rats. Toxicol Mech Methods. 2022 Mar;32(3):159-170. doi: 10.1080/15376516.2021.1976333. Epub 2021 Sep 22. 14:1143427. doi: 10.3389/fphar.2023.1143427.
合成参考文献
参考文献:10.1155/2012/125247 摘要:Chang CL, Lin CS. Phytochemical Composition, Antioxidant Activity, and Neuroprotective Effect ofTerminalia chebulaRetzius Extracts. Evidence-Based Complementary and Alternative Medicine. 2012;2012():1–7. doi: 10.1155/2012/125247.