CAS: 2304-98-5; (S)-2-(((Benzyloxy)Carbonyl)Amino)-5-(3-Nitroguanidino)Pentanoic Acid

上下游产品

CAS号2149-70-4 Nω-硝基-L-精氨酸 | CAS号501-53-1 氯甲酸苄酯 | CAS号74-79-3 L-精氨酸 | CAS号1119-34-2 L-精氨酸盐酸盐 | CAS号33515-09-2 黄体生成激素释放激素(LHRH) | CAS号74-79-3 L-精氨酸 | CAS号2896-20-0 H-Arg-Val-OH ac... | CAS号15706-88-4 ARG-ASP | CAS号123847-40-5 ethyl 4-[[2-[[4... | CAS号2047-13-4 H-ARG-PHE-OH | CAS号1188-24-5 H-ARG-LEU-OH | CAS号15706-89-5 H-ARG-GLU-OH | CAS号75957-60-7 斯耐潘定 | CAS号40968-46-5 H-ARG-LYS-OH

📜L-精氨酸盐酸盐置于sodium Hydroxide,硫酸,三氧化硫,硝酸,二氧化氮体系中,化学反应生成Nα-Cbz-Nω-硝基-L-精氨酸
参考文献:Gibian,H.; Schroeder,E.,Justus Liebigs Annalen Der Chemie,1961,Vol. 642,P. 145-162
标题:Gibian,H.; Schroeder,E.,Justus Liebigs Annalen Der Chemie,1961,Vol. 642,P. 145-162

专利信息

专利号:US-4704450-A
优先权日:1983-02-21
标 题 :Synthesis of hpGRF(Somatocrinin) in liquid phase and intermediate peptides
发明人：DIAZ JOSEPH; DEMARNE HENRI; RONCUCCI ROMEO; SCHMELCK PAUL-HENRY
权利人:SANOFI SA
摘要:The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising: coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group; selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

专利号:US-4581168-A
优先权日:1983-02-21
标题:Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides
发明人：DIAZ JOSEPH; DEMARNE HENRI; RONCUCCI ROMEO; SCHMELCK PAUL-HENRY
权利人:SANOFI SA
摘要:The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising:--coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group;--selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and--eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

专利号:US-4797469-A
优先权日:1984-07-10
标 题:Synthesis of hGRF (Somatocrinin) in liquid phase and intermediate peptides
发明人：DIAZ JOSEPH; DEMARNE HENRI; RONCUCCI ROMEO; SCHMELCK PAUL-HENRY
权利人:SANOFI SA
摘要:A process for the synthesis, in liquid phase and by fragments, of hGRF 1-44 and hGRF 1-40. This process consists in coupling, one after the other and in the order of the sequence of the GRF, (1) on the one hand, the following fragments: -H-Ala-Arg-Ala-Arg-Leu-NH2 called Fragment A hGRF (40-44) or - alaninamide (40) -H-Gln-Glu-Arg-Gly-OH called Fragment B'1 hGRF (36-39) -H-Glu-Ser-Asn-OH called Fragment B'2 hGRF (33-35) -H-Ser-Arg-Gln-Gln-Gly-OH called Fragment C hGRF (28-32) -H-Leu-Gln-Asp-Ile-Met-OH called Fragment D' hGRF (23-27) -H-Arg-Lys-Leu-OH called Fragment E'1 hGRF (20-22) - to obtain the peptide K1 [(hGRF (20-44)] on the corresponding peptide having the sequence (20-40) and (2) on the other hand, the following fragments: -H-Gln-Leu-Ser-Ala called Fragment F1 hGRF (16-19) -H-Tyr-Arg-Lys-Val-Leu-Gly OH called Fragment G1 hGRF (10-15) -H-Ile-Phe-Thr-Asn-Ser-OH called Fragment H1 hGRF (5-9) - to obtain the peptide J [hGRF (5-19)] and thereafter to couple together the peptides J and K1 in order to form the peptide having the sequence hGRF (5-44) or hGRF (5-40) and finally to couple the resulting peptide with the peptide H-Tyr-Ala-Asp-Ala-OH, called fragment I hGRF (1-4).

专利号:EP-0171315-B1
优先权日:1984-07-10
标题:Process for the synthesis of hgrf (somatocrinin) in the liquid phase, and intermediary peptides

专利号:CA-1267998-A
优先权日:1983-02-21
标题:Synthesis of hpgrf (somatocrinin) in liquid phase and intermediate peptides

专利号:EP-0122818-A1
优先权日:1983-02-21
标题:Liquid-phase synthesis of hpGRF (Somatocrinin) and intermediate peptides