📜Dipropyl Diethylphosphoramidodithioite,溶剂黄146 反应 1.0H,以64%的收率获得二乙胺乙酸盐 参考文献:Sinyashin,O. G.; Kostin,V. P.; Batyeva,E. S.,Journal Of General Chemistry Of The Ussr,1982,Vol. 52,# 12,P. 2382-2384 标题:Sinyashin,O. G.; Kostin,V. P.; Batyeva,E. S.,Journal Of General Chemistry Of The Ussr,1982,Vol. 52,# 12,P. 2382-2384
专利号:US-2015111934-A1 优先权日:2013-10-07 标 题:Crystalline forms of an adrenergic agonist 发明人:BOVE ALESSIO; ALLEGRINI PIETRO; ATTOLINO EMANUELE 权利人:DIPHARMA FRANCIS SRL 摘要:The present invention relates to the acetate salt of Mirabegron, in particular in two novel crystalline forms, a process for their preparation and the use of said salt and its crystalline forms in the synthesis of Mirabegron with high yields and chemical purity.
专利号:WO-2022094916-A1 优先权日:2020-11-06 标题:Method for improving activity of nicotinamide phosphoribosyltransferase, and composition thereof 发明人:YANG LIANG; LI XIANG 权利人:SHENZHEN INST OF ADV TECH CAS 摘要:A method for improving the activity of nicotinamide phosphoribosyltransferase, and a composition thereof. The method and composition are capable of increasing the deacetylation level of nicotinamide phosphoribosyltransferase (NAMPT) via a silent information regulator 2 related enzyme 1 (SIRT1), thus causing increased NAMPT activity, and further improving β-nicotinamide mononucleotide (β-NMN) and NAD+ levels. The composition is processed to improve the nicotinamide phosphoribosyltransferase activity by means of supplementing a certain amount of nicotine, resveratrol, or SRT 1720. Changes in NAD+ levels can regulate various physiological activities, such as DNA damage repair, carbohydrate metabolism and lipid metabolism, T cell activation, insulin release, the synthesis and degradation of proteins, the transmembrane signal transduction of cells and cellular senescence.
专利号:US-5869629-A 优先权日:1996-07-11 标题 :Synthesis of 9-deoxo-9a-aza-11,12-deoxy-9a-methyl-9a-homoerythromycin A 11,12 Hydrogenorthoborate dihydrate and a process for the preparation of azitromicin dihydrate 发明人:BAYOD JASANDA D MIGUEL SANTOS; FERNANDEZ GONZALEZ D JOSERAMON 权利人:ASTURPHARMA S A 摘要:The preparation of azitromycin dihydrate from 9-deoxo-9a-aza-11,12-deoxy-9a-methyl-9a-homoerythromycin A 11,12-hydrogenorthoborate, obtained by a step by step process starting from 9-deoxo-6-deoxy-6,9-epoxy-9,9a-dihydro-9a-azahomoerythromycin A is a process which takes place under mild conditions and with good yields.
专利号:CN-114264740-B 优先权日:2021-12-13 标 题:Determination of the active ingredients in the circulating catalyst for the synthesis of methacrolein
专利号:US-7615634-B2 优先权日:2003-02-10 标题:4-aminopyrimidine-5-one derivatives 发明人:BARTKOVITZ DAVID JOSEPH; CHU XIN-JIE; DING QINGJIE; JIANG NAN; LOVEY ALLEN JOHN; MOLITERNI JOHN ANTHONY; MULLIN JR JOHN GUILFOYLE; VU BINH THANH; WOVKULICH PETER MICHAEL 权利人:HOFFMANN LA ROCHE 摘要:Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.
专利号:WO-2007074391-A2 优先权日:2005-12-28 标题:Preparation of a key intermediate in the synthesis of rosuvastatin
参考文献:10.1007/s11581-025-06877-y 摘要:Nascimento AD, dos Reis RA, Santos JPS, Mattedi S, Senna LF. Impact of hydroxylation and ion structure on conductivity and stability of short-chain alkylammonium-based protic ionic liquids. Ionics. 2025 Dec 06;32(2):1635–49. doi: 10.1007/s11581-025-06877-y.