专利号:EP-4026837-A1 优先权日:2021-01-08 标 题:Process for producing 2,5-diamino-2,5-dideoxy-1,4:3,6-dianhydrohexitol 发明人:RUIJING GUO; PIRES RAUL; BEUCK SASKIA; LATORRE MARTINEZ IRENE CRISTINA; PAN XIANGCHENG; WANG QIANYI; YANG SHICHENG; JIANG YUAN 权利人:COVESTRO DEUTSCHLAND AG 摘要:The invention relates to a process for the synthesis of chiral diamines based on renewable resources. More specifically the invention provides a process for synthesis of diaminoisoidide, diaminoisosorbide, and diaminoisomannide, more specifically 2,5-diamino-2,5-dideoxy-1,4:3,6-dianhydrohexitols.
专利号:US-2023192718-A1 优先权日:2018-03-30 标 题 :Bicyclic enone carboxylates as modulators of transporters and uses thereof 发明人:SANDANAYAKA VINCENT 权利人:NIROGY THERAPEUTICS INC 摘要:The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.
专利号:US-6479668-B1 优先权日:1998-09-08 标 题 :Method of producing pyrrolidine derivatives 发明人:MURAOKA HIDEO; SATO HARUYO 权利人:TORAY INDUSTRIES 摘要:A method for producing pyrrolidine derivatives such as 3,4-epoxypyrrolodines, 3-pyrrolidols and the like, by oxidizing 3-pyrrolines with at least one peroxide in the presence of at least one acid is disclosed. The 3-pyrrolines are produced by deriving cis-2-butene compounds from cis-2-butene-1,4-diols and performing a cyclization between the cis-2-butene derivatives and at least one primary amine. The method may be performed as a one-pot synthesis and may be performed as a continuous reaction.
专利号:EP-3515880-B1 优先权日:2017-03-17 标题:Methods and compositions for synthesis of encoded libraries 发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN 权利人:HITGEN INC
专利号:US-2020149034-A1 优先权日:2017-03-17 标题:Methods and Compositions for Synthesis of Encoded Libraries
专利号:US-8034908-B2 优先权日:2003-02-14 标 题:Glycolipids and synthetic method thereof as well as their synthetic intermediates, and synthetic method thereof 发明人:ANNOURA HIROKAZU; MURATA KENJI; YAMAMURA TAKASHI 权利人:JAPAN GOVERNMENT 摘要:Novel glycolipid derivatives, where the substituent of the sphingosine base part is a short carbon chain alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group and efficient synthetic methods for practical mass production of the same and intermediates useful for the synthesis of these compounds. n Glycolipids having the formula (I): n nwhere R 3 indicates a substituted or unsubstituted C 1 to C 7 linear alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group, or substituted or unsubstituted aralkyl group and R 8 indicates a substituted or unsubstituted C 1 to C 35 alkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group are chemically synthesized.
参考标题:The Organocatalytic Synthesis Of Perfluorophenylsulfides Via The Thiolation Of Trimethyl(Perfluorophenyl)Silanes And Thiosulfonates 作者:Jinyun Luo,Muze Lin,Leifang Wu,Zhihua Cai,Lin He,Guangfen Du 摘要:The Organic Superbase T-Bu-P4-Catalyzed Direct Thiolation Of Trimethyl(Perfluorophenyl)Silanes And Thiosulfonates Was Developed. Yields Of Perfluorophenylsulfides Of Up To 97% Under Catalysis Of 5 Mol% T-Bu-P4 Were Achieved. This Method Was Shown To Provide An Efficient Way To Construct The Perfluorophenyl-Sulfur Bond Under Mild Metal-Free Reaction Conditions.
合成参考文献
摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 284. 摘要:Kashemirov, B. A.; Błażewska, K.; Justyna, K.; Lyu, J.; McKenna, C. E., Science of Synthesis Knowledge Updates, (2021) 1, 414. 摘要:Inamoto, K., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 432. 摘要:Das, A.; Sarmah, B. K., Science of Synthesis: Knowledge Updates, (2024) 1, 339.