CAS: 175202-48-9; Methyl 4-Cyano-5-(Methylthio)Thiophene-2-Carboxylate

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methyl 3-amino-4-cyano-5-(methylsulfanyl)-2-thiophenecarboxylate [Bis(methylthio)methylene]malononitrilemethyl 4-cyano-5-[(4-methoxyphenyl)methylthio]thiophene-2-carboxylate methyl 5-methoxy-4-(4-phenyl(1,3-thiazol-2-yl))thiophene-2-carboxylate methyl 4-(aminothioxomethyl)-5-[(4-methoxyphenyl)methylthio]thiophene-2-carboxylate 5-(4-methoxy-benzylsulfanyl)-4-(4-phenyl-thiazol-2-yl)-thiophene-2-carboxylic acid methyl ester

📜[双(甲硫基)亚甲基]丙烷二腈置于三乙胺,亚硝酸异戊酯体系中,用 甲醇,N,N-二甲基甲酰胺 用作溶剂,化学反应生成4-氰基-5-(甲硫基)噻吩-2-羟酸甲酯
参考文献:Synthesis Of Thiophene-2-Carboxamidines Containing 2-Amino-Thiazoles And Their Biological Evaluation As Urokinase Inhibitors
标题:Synthesis Of Thiophene-2-Carboxamidines Containing 2-Amino-Thiazoles And Their Biological Evaluation As Urokinase Inhibitors
摘要:The Serine Protease Urokinase (Upa) Has Been Implicated In The Progression Of Both Breast And Prostate Cancer. Utilizing Structure Based Design,The Synthesis Of A Series Of Substituted 4-[2-Amino-1,3-Thiazolyl]-Thiophene-2-Carboxamidine Is Described. Further Optimization Of This Series By Substitution Of The Terminal Amine Yielded Urokinase Inhibitors With Excellent Activities. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0960-894X(01)00102-0