CAS: 161832-74-2; (R)-2-Amino-4-Methyl-1,1-Diphenylpentan-1-Ol
该化合物是一种手性有机化合物,其特点是其特定的立体化学(由(R)配置表示),该化合物的特点是氨基氨基化合物(-NH2)和一个氢氧基化合物(-OH),使其成为氨基醇,与中央碳相连的两个苯基组的存在有助于其疏水特性,而氨基和氢氧基化合物组则引入极性功能组,允许潜在的氢结合.这种双重性会影响其溶液在各种溶剂中的溶性.该化合物通常在不对称合成过程中研究,并可作为合成药物的手性辅助剂或建筑块.其独特结构允许生物系统中的特定互动,使其对药用化学感兴趣.此外,该化合物的立体化学学在确定其生物活动和药基营养学方面发挥着关键作用,而后者是药物开发和设计中的重要因素.
- 英文名称(R)-2-Amino-4-Methyl-1,1-Diphenylpentan-1-Ol
- 中文名称(R)-2-氨基-4-甲基-1,1-二苯基戊-1-醇
- IUPAC名称(2R)-2-amino-4-methyl-1,1-diphenylpentan-1-ol
- 其它别名(R)-(+)-2-氨-4-甲基-1,1-联苯-1-丙醇; (R)-(+)-2-Amino-4-Methyl-1,1-Diphenyl-1-Pentanol
- CAS编号161832-74-2
- MFCD编号:MFCD03093530
- EINECS号:621-429-5
- 分子式:C18H23NO分子量:269.38
- 产品CID: 817330
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
78603-95-9 86695-06-9 78603-91-5物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
methyl (L)-leucinate hydr°Chloride phenylmagnesium bromide bromobenzene (R)-leucine methyl ester hydr°Chloride (S)-2-{[1-(3-{[(E)-(S)-1-(Hydroxy-diphenyl-methyl)-3-methyl-butylimino]-methyl}-phenyl)-meth-(E)-ylidene]-amino}-4-methyl-1,1-diphenyl-pentan-1-ol -m-xylylenediamine(-)-(1S)-bis-m-xylylenediamine (R)-N-((R)-1-hydroxy-4-methyl-1,1-diphenylpentan-2-yl)pyrrolidine-2-carboxamide合成工艺路线路线简述
- 合成目标产物 (R)-(+)-2-Amino-4-Methyl-1,1-Diphenyl-1-Pentanol 主要起始原料 Methyl L-Leucinate Hydrochloride And Phenylmagnesium Bromide
- (文献来源)合成步骤主要原料 Methyl L-Leucinate Hydrochloride 和 Phenylmagnesium Bromide
📜D-亮氨酸置于氯化亚砜,Magnesium体系中,用 乙醚 用作溶剂,化学反应 18.5H,反应生成(R)-(+)-2-氨基-4-甲基-1,1-二苯基-1-戊醇
参考文献:Large-Scale Synthesis Of Singh's Catalyst In A One-Pot Procedure Starting From Proline
标题:Large-Scale Synthesis Of Singh's Catalyst In A One-Pot Procedure Starting From Proline
摘要:A Practical One-Pot Procedure For The Preparation Of Singh'S Catalyst From Either L-/d-Proline Or Boc-Proline Is Described. The Coupling Partner,A Chiral Amino Alcohol,Can Be Prepared And Used Directly Without Purification From The Corresponding Amino Acid Ester. Moreover,A Procedure For Tert-Butoxycarbonyl (Boc) Group Removal Using Concentrated Hcl In Meoh-Dcm Was Developed And Utilized For The Multigram-Scale Synthesis Of Singh'S Catalyst.
Doi:10.1021/op200283Q
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2906210000-苄醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:EP-1730108-B1
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin d analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.
专利号:EP-1735276-B1
优先权日:2004-04-02
标题:Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues
发明人：HANSEN ERIK TORNGAARD; SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; PEDERSEN HENRIK; DEUSSEN HEINZ-JOSEF WILHELM
权利人:LEO PHARMA AS
摘要:The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.
专利号:US-8759555-B2
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin D analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.
专利号:RU-2378252-C2
优先权日:2004-04-02
标题 :Novel method for synthesis of intermediate compounds, used in synthesis of vitamin d analogues
专利号:US-2007027333-A1
优先权日:2004-03-18
标题 :Stereoselective synthesis of vitamin d analogues
专利号:CA-2555260-C
优先权日:2004-03-18
标 题 :Stereoselective synthesis of vitamin d analogues
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Direction Of Kinetically Versus Thermodynamically Controlled Organocatalysis And Its Application In Chemoenzymatic Synthesis作者:Giuseppe Rulli,Nongnaphat Duangdee,Katrin Baer,Werner Hummel,Albrecht Berkessel,Harald Gröger |发布日期:2011.8.16
摘要:The Catalyst Loading In The Narrow Range Between 0.5 And 10 Mol % Determines Whether An Enantioselective Organocatalytic Aldol Reaction Proceeds Under Kinetic Or Thermodynamic Control; High Conversions And Ee Values Can Be Achieved With Low Catalyst Loadings (See Scheme). Since The Reaction Is Carried Out In Water, It Can Be Combined With A Biocatalytic Reduction For The One‐pot Synthesis Of 1,3‐diols
合成参考文献
参考文献:10.1055/s-0040-1707235
摘要:Khangarot RK, Khandelwal M, Ray SK. Syntheses and Applications of Singh’s Catalyst. Synthesis. 2020 Aug 19;52(23):3577–82. doi: 10.1055/s-0040-1707235.
📝 需求与反馈
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