CAS: 149849-92-3; 2-Chloropyrimidine-4-Carboxylic Acid

相似化合物

75833-38-4 149849-94-5 1196152-00-7

上下游产品

CAS号149849-93-4 2-氯嘧啶-4-羰基氯 | CAS号149849-93-4 2-氯嘧啶-4-羰基氯 | CAS号1196152-00-7 2-氯嘧啶-4-羧酸乙酯

2-氯-4-甲基嘧啶置于n-羟基邻苯二甲酰亚胺,二乙二醇二甲醚,氧气,Cobalt(II) Acetate,Manganese(II) Acetate体系中,用 溶剂黄146 用作溶剂,化学反应 2.0H,以80.8%的收率获得2-氯-4-嘧啶甲酸
参考文献:2-氯嘧啶-4-甲酸类化合物的连续性合成方法
标题:2-氯嘧啶-4-甲酸类化合物的连续性合成方法
摘要:本发明提供了一种2‑氯嘧啶‑4‑甲酸类化合物的连续性合成方法.2‑氯嘧啶‑4‑甲酸类化合物具有式i所示结构:式i式i中,R1和r2分别独立地选自氢,烷氧基,芳基,苄基或氟;合成方法包括以下步骤:S1,在非贵金属催化剂的作用下,将化合物a与甲基格氏试剂b进行连续甲基化反应,得到化合物c;化合物a为,化合物c为,R1和r2具有与前文相同定义,非贵金属催化剂为铁盐,钴盐,镍盐中的一种或多种;S2,将化合物c在氧气,氧化催化剂及添加剂的作用下进行连续氧化反应,得到2‑氯嘧啶‑4‑甲酸类化合物.采用本发明提供的工艺合成2‑氯嘧啶‑4‑甲酸类化合物,能够兼顾成本,收率,环保性等方面.

专利信息

专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:CN-110642789-A
优先权日:2019-11-25
标题:Continuous synthesis method of 2-chloropyrimidine-4-carboxylic acid compounds

专利号:CN-112851677-A
优先权日:2019-11-26
标题:Synthesis method of imidazopyridine or pyrimidine derivative

专利号:CN-110642789-B
优先权日:2019-11-25
标题:Continuous synthesis method of 2-chloropyrimidine-4-formic acid compound