📜[(三氟甲基)亚磺酰]苯置于三氟甲磺酸酐体系中,用 苯 用作溶剂,以40%的收率获得二苯基(三氟甲基)锍三氟甲磺酸盐 参考文献:Method For Condensation Of Aromatic Derivative(S) And A Sulphinic Derivative 标题:Method For Condensation Of Aromatic Derivative(S) And A Sulphinic Derivative 摘要:本发明涉及一种通过一种卤代,优选为全氟碳原子,对芳香衍生物或亚磺酸衍生物进行缩合的方法.该方法的特点在于将所述亚磺酸衍生物和所述芳香衍生物置于pka不超过0的强酸的作用下.本发明适用于有机合成.
专利号:WO-2024041503-A1 优先权日:2022-08-22 标 题:Compounds targeting y220c mutant of p53 发明人:LI SUJING; LI AMIN; ZHENG QIAN; Dang Chaojie; FAN XINRUI; LONG WEI; WANG YANPING 权利人:JACOBIO PHARMACEUTICALS CO LTD 摘要:The present invention discloses compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are processes for the synthesis and use of the compounds of formula (I).
专利号:US-6486351-B1 优先权日:1998-09-14 标 题 :Method for condensation of aromatic derivative(s) and a sulphinic derivative 发明人:SAINT-JALMES LAURENT; TORDEUX MARC; WAKSELMAN CLAUDE 权利人:RHODIA CHIMIE SA 摘要:The invention concerns a method for the condensation of aromatic derivative(s) or a sulphinic derivative by a perhalogenated, advantageously perfluorinated, carbon atom. Said method is characterized in that it consists in subjecting said sulphinic derivative and said aromatic derivative to the action of a strong acid whereof the pKa is not more that 0. The invention is applicable to organic synthesis.
专利号:CN-117486856-A 优先权日:2023-11-02 标题 :A kind of synthesis method of 4-bromo-5-(trifluoromethyl)thiophene-2-carboxylic acid methyl ester