CAS: 124584-08-3; Nesiritide

专利信息

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-8742013-B2
优先权日:2009-04-24
标 题:Synthesis of lipoamide-grafted high molecular compound and method therefor
发明人：NOH INSUP; JO SEONGYEUN; KIM DOYEON; WOO JUNGHOON
权利人:NOH INSUP; JO SEONGYEUN; KIM DOYEON; WOO JUNGHOON; NAT UNIV SEOUL TECH CTENTER
摘要:The present disclosure provides polymer compounds binding with lipoamide produced by the reaction of the primary amine group of lipoamide with the carboxy group of polysaccharide compounds such as chondroitin sulfates, carboxymethyl celluloses, or hyaluronic acids; functional compounds such as peptides, proteins, growth factors; or drugs; or biocompatible polymers such as poly(ethylene oxide), poly(vinyl alcohol), or poly(vinyl pyrrolidone). The present disclosure also provides their synthesis methods, products of hydrogels and films using the same as and methods for manufacturing the products.

专利号:US-5352587-A
优先权日:1989-06-23
标 题:Compositions and methods for the synthesis of natriuretic protein receptor B and methods of use
发明人：CHANG MING-SHI; GOEDDEL DAVID V; LOWE DAVID G
权利人:GENENTECH INC
摘要:PCT No. PCT/US90/03586 Sec. 371 Date Dec. 19, 1991 Sec. 102(e) Date Dec. 19, 1991 PCT Filed Jun. 22, 1990 PCT Pub. No. WO91/00292 PCT Pub. Date Jan. 10, 1991.Described are the amino acid sequence of natriuretic peptide receptor B (NPRB) and DNA encoding NPRB. Also disclosed are expression vectors and cells transformed to express the NPRB, DNA encoding NPRB and diagnostic and therapeutic uses for the NPRB and the DNA encoding NPRB.

专利号:US-9695214-B2
优先权日:2013-03-15
标 题 :Solid phase peptide synthesis processes and associated systems
发明人：SIMON MARK DAVID; PENTELUTE BRADLEY L; ADAMO ANDREA; HEIDER PATRICK LOUIS; JENSEN KLAVS F
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

专利号:US-2006121565-A1
优先权日:2002-09-20
标题:Methods for increasing the production of a recombinant polypeptide from a host cell
发明人：JONSON LARS; REHFELD JENS F; JOHNSEN ANDERS H
权利人:CYMIP AS
摘要:The present invention provides a host cell comprising a nucleic acid sequence encoding a recombinant polypeptide in which the production of a naturally occurring metalloprotease comprising a sequence provided in SEQ ID NO:1 has been reduced or inhibited by genetic manipulation. The present invention also relates to methods for enhancing the production of a polypeptide from a cell by disrupting the synthesis or activity of the metalloprotease. In particular, the present invention relates to methods for enhancing the secretion of recombinant polypeptides from host cells such as, but not limited to, yeast and bacterial cells. The metalloprotease is a member of the pitrilysin subfamily of proteases, characterized by comprising the sequence HXXEH (SEQ ID NO:1), where X is any amino acid.