CAS: 121-75-5; Malathion

该化合物是一种有机磷杀虫剂,广泛用于农业和公共卫生,用于虫害控制,其特点是相对于其他有机磷,它对哺乳动物的毒性相对较低,因此它是各种应用的首选;马拉硫磷是一种无色的,淡黄色的液体,具有略微甜味,在有机溶剂中可溶解,但在水中溶解性有限;其化学结构包括一个磷酸盐组,该组通过抑制酶乙酰胆碱酯酶,导致乙酰胆碱累积,并导致害虫正常...

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欧盟法规

《欧盟PIC法规》统一分类与标签"欧盟管控危险化学品"ECHA物质ECHA物质工作场所安全标识要求欧盟农药活性物质C&L通报OtherREACH预注册废弃物危险特性清单

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CAS号756-80-9 二硫代磷酸O,O'-二甲酯 | CAS号141-05-9 顺丁烯二甲酸二乙酯 | CAS号67-56-1 甲醇 | CAS号623-91-6 富马酸二乙酯 | CAS号26377-29-7 O,O-二甲基硫代磷酸钠 | CAS号64-17-5 乙醇 | CAS号17013-01-3 富马酸钠 | CAS号7554-12-3 DL-苹果酸二乙酯 | CAS号756-80-9 二硫代磷酸O,O'-二甲酯 | CAS号1190-28-9 马拉硫磷二羧酸 | CAS号3344-12-5 异甲基硫 | CAS号1634-78-2 马拉氧磷 | CAS号71133-16-9 1-carboethoxy-2... | CAS号33779-98-5 2-carboethoxy-1...

合成工艺路线路线简述

    富马酸二乙酯 反应生成马拉松
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    专利信息


    专利号:US-5206392-A
    优先权日:1992-04-27
    标 题:Facile synthesis of arylmaleic acids and anhydrides
    发明人:DEAN WILLIAM D
    权利人:AMERICAN CYANAMID CO
    摘要:A process for making acrylmaleic acid and arylmaleic anhydride derivative useful as intermediates for the preparation of arylmaleimides in the synthesis of compounds having activity in the central nervous system. The process involves reacting arylacetonitriles with glyoxylic acid to provide novel intermediate 3-aryl-3-cyanopropeneoates which may be converted to the arylmaleic acid and arylmaleic anhydride derivatives.

    专利号:US-7002017-B2
    优先权日:2003-03-24
    标题 :Enantioselective hydrogenation of intermediates in the synthesis of tipranavir
    发明人:KLINGLER FRANZ DIETRICH; STEIGERWALD MICHAEL; EHLENZ RICHARD
    权利人:BOEHRINGER INGELHEIM INT
    摘要:The invention relates to a process for preparing the compounds of general formula I n nby enantioselective hydrogenation of the compounds of formula II n nin the presence of special hydrogenation catalysts. The invention is characterised by high enantioselectivity, providing easy access to a category of important pharmaceutical compositions, i.e. intermediates for the synthesis of tipranavir.

    专利号:US-7994098-B2
    优先权日:2005-12-09
    标 题:Light directed DNA synthesis using inverse capping for error reduction
    发明人:KIM CHANGHAN; CERRINA FRANCO
    权利人:WISCONSIN ALUMNI RES FOUND
    摘要:A prepared substrate upon which light directed DNA synthesis is to occur is exposed to light via an inverse mask pattern to deprotect inactive regions of the substrate where the synthesis is not intended to occur. The deprotected sites are then capped to disable permanently the inactive areas, thereby forming an inverse capped substrate. Unwanted DNA synthesis in the inactive areas is thus prevented, resulting in purer quality DNA, even though such areas may be exposed to light due to diffraction, scattering and flare during subsequent DNA synthesis of the intended active areas of the substrate.

    专利号:US-4774173-A
    优先权日:1984-12-06
    标 题 :Microbiological assay kit and method for detecting de novo biomolecular synthesis inhibitors
    发明人:REINHARTZ AVRAHAM
    权利人:ORGENICS LTD
    摘要:A method for assaying a specimen for the presence of a substance capable of inhibiting de novo biomolecular synthesis in a test microorganism, which comprises: exposing a cell wall permeability-enhanced test microorganism exhibiting delayed de novo synthesis of said biomolecule to said specimen, and assaying the extent of inhibition of synthesis of said biomolecule in said microorganism. A kit is described for performing the method, as well as a reaction mixture for performing the technique.

    专利号:US-2015099864-A1
    优先权日:2013-10-08
    标题:Preparation of organophosphate peptide adducts
    发明人:BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
    权利人:BATTELLE MEMORIAL INSTITUTE
    摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.

    专利号:WO-2015053980-A1
    优先权日:2013-10-08
    标 题 :Preparation of organophosphate peptide adducts
    发明人:BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
    权利人:BATTELLE MEMORIAL INSTITUTE
    摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.
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    主要参考文献


    1: Zhang Y, Wu L, Zhang G, Guan Y, Wang Z. Effect of low-dose malathion on the gonadal development of adult rare minnow Gobiocypris rarus. Ecotoxicol Environ Saf. 2016 Mar;125:135-40. doi: 10.1016/j.ecoenv.2015.11.041. Epub 2015 Dec 10. doi: 10.1016/j.tiv.2015.12.006. Epub 2015 Dec 10. doi: 10.1007/s00204-015-1466-0. Epub 2015 Jan 25. doi: 10.1016/j.cbpc.2015.11.001. Epub 2015 Nov 24. doi: 10.1002/etc.3189. Epub 2016 Jan 19. doi: 10.1093/jee/tov276. Epub 2015 Sep 11. doi: 10.1016/j.pestbp.2015.07.006. Epub 2015 Jul 29. doi: 10.1093/toxsci/kfv223. Epub 2015 Oct 22.
    10: Ghosh SK, Pal S. Entomopathogenic potential of Trichoderma longibrachiatum and its comparative evaluation with malathion against the insect pest Leucinodes orbonalis. Environ Monit Assess. 2016 Jan;188(1):37. doi: 10.1007/s10661-015-5053-x. Epub 2015 Dec 17. doi: 10.1016/j.aquatox.2015.11.023. Epub 2015 Nov 25. doi: 10.3109/01913123.2015.1088908. Epub 2015 Oct 29. doi: 10.1016/j.cbpc.2015.08.004. Epub 2015 Aug 19. doi: 10.1038/srep18394.
    15: Saeedi Saravi SS, Amirkhanloo R, Arefidoust A, Yaftian R, Saeedi Saravi SS, Shokrzadeh M, Dehpour AR. On the effect of minocycline on the depressive-like behavior of mice repeatedly exposed to malathion: interaction between nitric oxide and cholinergic system. Metab Brain Dis. 2015 Nov 19. [Epub ahead of print] doi: 10.1007/s11356-015-5014-5. Epub 2015 Jul 11. doi: 10.1007/s10661-015-4865-z. Epub 2015 Oct 19.

    合成参考文献


    参考文献:10.3390/ijms12064120
    摘要:Kim IS, Yang MR, Lee OH, Kang SN. Antioxidant activities of hot water extracts from various spices. Int J Mol Sci. 2011;12(6):4120–31.
    参考文献:10.2174/138955711796575434
    摘要:Orhan IE, Orhan G, Gurkas E. An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production. Mini Rev Med Chem. 2011 Sep;11(10):836–42. doi: 10.2174/138955711796575434.
    参考文献:10.1016/j.aca.2011.06.014
    摘要:Chauhan N, Pundir CS. An amperometric biosensor based on acetylcholinesterase immobilized onto iron oxide nanoparticles/multi-walled carbon nanotubes modified gold electrode for measurement of organophosphorus insecticides. Anal Chim Acta. 2011 Sep 02;701(1):66–74. doi: 10.1016/j.aca.2011.06.014.
    参考文献:10.1002/etc.623
    摘要:Fuentealba González P, Llanos-Rivera A, Carvajal Baeza N, Uribe Pérez E. Xenobiotic-induced changes in the arginase activity of zebrafish (Danio rerio) eleutheroembryo. Environ Toxicol Chem. 2011 Oct;30(10):2285–91. doi: 10.1002/etc.623.
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