专利号:US-5206392-A 优先权日:1992-04-27 标 题:Facile synthesis of arylmaleic acids and anhydrides 发明人:DEAN WILLIAM D 权利人:AMERICAN CYANAMID CO 摘要:A process for making acrylmaleic acid and arylmaleic anhydride derivative useful as intermediates for the preparation of arylmaleimides in the synthesis of compounds having activity in the central nervous system. The process involves reacting arylacetonitriles with glyoxylic acid to provide novel intermediate 3-aryl-3-cyanopropeneoates which may be converted to the arylmaleic acid and arylmaleic anhydride derivatives.
专利号:US-7002017-B2 优先权日:2003-03-24 标题 :Enantioselective hydrogenation of intermediates in the synthesis of tipranavir 发明人:KLINGLER FRANZ DIETRICH; STEIGERWALD MICHAEL; EHLENZ RICHARD 权利人:BOEHRINGER INGELHEIM INT 摘要:The invention relates to a process for preparing the compounds of general formula I n nby enantioselective hydrogenation of the compounds of formula II n nin the presence of special hydrogenation catalysts. The invention is characterised by high enantioselectivity, providing easy access to a category of important pharmaceutical compositions, i.e. intermediates for the synthesis of tipranavir.
专利号:US-7994098-B2 优先权日:2005-12-09 标 题:Light directed DNA synthesis using inverse capping for error reduction 发明人:KIM CHANGHAN; CERRINA FRANCO 权利人:WISCONSIN ALUMNI RES FOUND 摘要:A prepared substrate upon which light directed DNA synthesis is to occur is exposed to light via an inverse mask pattern to deprotect inactive regions of the substrate where the synthesis is not intended to occur. The deprotected sites are then capped to disable permanently the inactive areas, thereby forming an inverse capped substrate. Unwanted DNA synthesis in the inactive areas is thus prevented, resulting in purer quality DNA, even though such areas may be exposed to light due to diffraction, scattering and flare during subsequent DNA synthesis of the intended active areas of the substrate.
专利号:US-4774173-A 优先权日:1984-12-06 标 题 :Microbiological assay kit and method for detecting de novo biomolecular synthesis inhibitors 发明人:REINHARTZ AVRAHAM 权利人:ORGENICS LTD 摘要:A method for assaying a specimen for the presence of a substance capable of inhibiting de novo biomolecular synthesis in a test microorganism, which comprises: exposing a cell wall permeability-enhanced test microorganism exhibiting delayed de novo synthesis of said biomolecule to said specimen, and assaying the extent of inhibition of synthesis of said biomolecule in said microorganism. A kit is described for performing the method, as well as a reaction mixture for performing the technique.
专利号:US-2015099864-A1 优先权日:2013-10-08 标题:Preparation of organophosphate peptide adducts 发明人:BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T 权利人:BATTELLE MEMORIAL INSTITUTE 摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.
专利号:WO-2015053980-A1 优先权日:2013-10-08 标 题 :Preparation of organophosphate peptide adducts 发明人:BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T 权利人:BATTELLE MEMORIAL INSTITUTE 摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.
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