CAS: 1117-71-1; Methyl 4-Bromobut-2-Enoate

相似化合物

13991-36-1 6000-00-6 37746-78-4

上下游产品

CAS号623-43-8 巴豆酸甲酯 | CAS号3724-65-0 巴豆酸 | CAS号100038-62-8 methyl 4-phenyl... | CAS号5837-73-0 DL-2-羟基-3-丁烯酸甲酯 | CAS号56-23-5 四氯化碳 | CAS号67-56-1 甲醇 | CAS号13991-36-1 4-溴代巴豆酸 | CAS号3699-18-1 2,6-PIPERIDINED... | CAS号71-43-2 苯 | CAS号111042-30-9 (2,3-DIHYDRO-BE... | CAS号623-43-8 巴豆酸甲酯 | CAS号3724-55-8 3-丁烯酸甲酯 | CAS号143140-68-5 methyl 2-(1-hyd... | CAS号4493-42-9 2,4-葵二烯酸甲酯 | CAS号4619-18-5 4-(4-氯苯基)丁酸 | CAS号183742-32-7 2-(1,4-二苄基哌嗪-2-... | CAS号22991-05-5 4-(3-氯苄基)丁酸 | CAS号25157-66-8 4-(3,4-dichloro...

巴豆酸甲酯置于n-溴代丁二酰亚胺(Nbs),过氧化氢苯甲酰体系中,用 四氯化碳 用作溶剂,化学反应 7.0H,反应生成4-溴巴豆酸甲酯
参考文献:取代的烯丙基卤化物中的烯丙基与α,β-不饱和酯的电化学共轭加成
标题:取代的烯丙基卤化物中的烯丙基与α,β-不饱和酯的电化学共轭加成
摘要:在含有 0.2 M† 甲苯磺酸四乙基铵的 N,N'-二甲基甲酰胺中电解烯丙基卤和富马酸二乙酯 (2) 得到共轭加成产物 3-(乙氧基羰基)-5-己烯酸乙酯,收率适中.1-氯-3-甲基-2-丁烯(4)与2的电化学反应,烯丙基氯4与巴豆酸甲酯(6)的电化学反应,以及4-卤代-2-丁烯酸甲酯与2的电化学反应同样得到相应的共轭加成产物,3-(乙氧羰基)-6-甲基-5-庚烯酸乙酯,3,4,4-三甲基-5-己烯酸甲酯和3-(乙氧羰基)-4-(甲氧羰基)-5-己烯酸乙酯,分别.4 至 2 的加成反应仅发生在 4 的 α-碳末端,而 4 至 6 的加成反应发生在 4 的 γ-碳末端.讨论了这些加成反应的区域选择性和反应途径.
Doi:10.1246/bcsj.54.3456

专利信息

专利号:US-9556140-B2
优先权日:2013-01-26
标 题 :Approach for synthesis of catechins
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; RAI KUMAR SANTOSH; TRIPATHI VINAYAK; PATIL ISHWAR RAKESH
权利人:SPHAERA PHARMA PRIVATE LTD
摘要:A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

专利号:US-9242965-B2
优先权日:2013-12-31
标题:Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
发明人：ZHENG JUNCHENG; DENG DA; LV GUANGHUA; YAN JUN; BRANDENBURG JOERG; KROEBER JUTTA; SCHOLZ ULRICH
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I n nwherein R 1 and R 2 independently denote C 1-3 -alkyl groups and X − denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

专利号:US-6455680-B1
优先权日:2000-12-21
标 题 :Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
发明人：LUKIN KIRILL A
权利人:ABBOTT LAB
摘要:An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.

专利号:US-9428482-B2
优先权日:2011-01-27
标 题 :Process for synthesis of polyphenols
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE
权利人:DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE; SPHAERA PHARMA PTE LTD
摘要:The present invention provides synthetic processes for preparing racemic and/or optically pure epicatechin, epigallocatechin and related polyphenols as such or as their variously functionalized derivatives. A principle objective of the disclosure is to provide a new and useful method of synthesis to obtain polyphenols in isomerically pure and/or racemic forms.

专利号:US-7126025-B2
优先权日:2003-01-21
标 题 :Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
发明人：CONSIDINE JOHN LEO; DAIGNEAULT SYLVAIN; CHEW WARREN; IERA SILVIO; DUNCAN SCOTT MASON; REN JIANXIN
权利人:WYETH CORP
摘要:This invention provides a compound of Formula (I): n nwhereinn S 1 and S 2 are each independently, hydrogen, alkyl, alkenyl, alkynyl, aralkyl, substituted or unsubstituted aryl, and S 1 and S 2 together with the nitrogen to which they are attached form a nitrogen containing heteroaryl and a pharmaceutically acceptable salt thereof; a method of preparing the compound of Formula (I), and use of the compound of Formula (I) in the preparation of 3-cyano quinolines.

专利号:WO-03013740-A1
优先权日:2001-08-03
标题 :4- AND 5-AMINO-α, β UNSTATURATED ESTER SOLID SUPPORT TEMPLATES, METHOD OF PREPARATION AND FOR USING THE SAME
发明人：LOU BOLIANG; MAJJLI ADNAN M M
权利人:ADVANCED SYNTECH LLC
摘要:A substituted α, β-unsaturated ester template of the general formula (1) where: P is an insoluble substrate; n is 1 or 2; X is an atom or a functional group connecting the polymer and the linker L. having a structure such as but not limited to oxygen, ester, amide, sulfur, silicon and carbon; L is a multifunctional chemical monomer in which one functional group reacts with the polymer to form a covalent bond (X) and one other of the functional groups react with one of the R groups (R1, R2, R3, R5, or R6) through a plurality of chemical reactions to provide the desired templates for further chemistry. The ester template is useful for the solid phase synthesis of heterocycle compounds.