CAS: 96568-02-4; 2,6-Dichloro-5-Fluoronicotinoyl Chloride
该化合物是一种氟化尼古丁氯化物衍生物,主要用作有机合成的关键中间体,特别是在制药业和农用化学工业中,其反应式丙基氯组得以有效衍生,促进将2,6-二氯-5-氟尼基诺基分子引入目标分子中.该化合物的氟代用能增强代谢稳定性和下游应用中的生物利用率.该化合物在合成活性药物成分和作物保护剂方面特别有用.高纯度能确保混合反应的一贯性.建议在空气中进行适当的惰性处理,因为其湿度敏感性.该介质为先进的异环化学提供了多功能性建筑块.
- 英文名称2,6-Dichloro-5-Fluoronicotinoyl Chloride
- 中文名称2,6-二氯-5-氟代烟酰氯
- IUPAC名称2,6-dichloro-5-fluoronicotinoyl chloride
- 其它别名2,6-Dichloro-5-Fluoronicotinoyl Chloride; 2,6-Dichloro-5-Fluoropyridine-3-Carbonyl Chloride; 2,6-Dichloro-5-Fluoro-3-Pyridinecarbonyl Chloride; 2,6-Dichloro-5-Fluoro-Pyridine-3-Carbonyl Chloride; Aatvxelayclvtj-Uhfffaoy
- CAS编号96568-02-4
- MFCD编号:MFCD01863240
- EINECS号:624-647-9
- FDA UNII编号:NRM82XP2HF
- 分子式:C6HCl3FNO分子量:228.44
- 产品CID: 2018006
- 产品分类医药中间体 → 吡啶类化合物
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: AATVXELAYCLVTJ-UHFFFAOYSA-N
- InChI=1S/C6HCl3FNO/c7-4-2(6(9)12)1-3(10)5(8)11-4/h1H
- 计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数1.0
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
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📜2,6-二氯-5-氟吡啶-3-羧酸乙酯置于盐酸,氯化亚砜,三氟乙酸体系中,用 水 作为反应溶剂,化学反应 28.5H,反应生成 2,6-二氯-5-氟代烟酰氯
参考文献:Antiviral And Antimicrobial Compounds
标题:Antiviral And Antimicrobial Compounds
摘要:本文披露了具有抗病毒和抗菌活性的胍和双胍衍生物.还披露了含有这些化合物作为活性成分的药物组合物,以及利用这些化合物的抗病毒和抗菌方法.还披露了使用胍和双胍衍生物治疗感染的方法.
海关参考信息
- 2912110000-甲醛
2933310010-吡啶
2903110000-一氯甲烷及氯乙烷
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-5204478-A
优先权日:1992-08-20
标题 :Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride
发明人：JENNINGS REX A
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy-5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluoronicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5-fluoronicotinic acid.
专利号:US-11059788-B2
优先权日:2017-06-12
标 题:Streamlined syntheses of fluoroquinolones
发明人：GUPTON FRANK B; TOSSO PERRER N
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:Methods of synthesizing fluoroquinolones such as ciprofloxacin are provided. The methods utilize affordable materials, reduce the number of synthesis steps and provide high yields.
专利号:EP-0655998-B1
优先权日:1992-08-20
标题:Improved process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride
专利号:EP-0655998-A1
优先权日:1992-08-20
标 题 :METHOD FOR THE SYNTHESIS OF 2,6-DICHLOR-5-FLUORNICOTINIC ACID AND 2,6-DICHLOR-5-FLUORNICOTINOYL CHLORIDE.
专利号:WO-9404501-A1
优先权日:1992-08-20
标题 :Improved process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride
专利号:CZ-286204-B6
优先权日:1992-08-20
标 题:Improved synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2010).
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