CAS: 87206-44-8; (R)-2-Amino-4-(Methylthio)Butan-1-Ol

相似化合物

2899-37-8 51372-93-1 2491-18-1

上下游产品

D-methionine isopropyl ester tert-butyl (1R)-1-(hydroxymethyl)-3-(methylsulfanyl)propylcarbamate D-methionine N-t-butoxycarbonyl-D-methionineR)-4-methylsulfanyl-2-(4-nitro-benzoylamino)-1-(4-nitro-benzoyloxy)-butane(R)-4-methylsulfanyl-2-(4-nitro-benzoylamino)-1-(4-nitro-benzoyloxy)-butane 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-4-methylsulfanyl-2-(3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-butyl ester -2-phenyl-1,3-oxazole(4S)-4,5-dihydro-4-2-(methylsulfanyl)ethyl-2-phenyl-1,3-oxazole (R)-N-[1-hydroxy-4-(methylthio)butan-2-yl]-4-methylbenzenesulfonamide

D-蛋氨酸置于sodium Tetrahydroborate,碘体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 D-蛋氨醇
参考文献:Dabco催化各种亲核试剂与活化炔烃的反应,导致形成烯酸酯,1,4-二恶烷,吗啉和哌嗪酮衍生物
标题:Dabco催化各种亲核试剂与活化炔烃的反应,导致形成烯酸酯,1,4-二恶烷,吗啉和哌嗪酮衍生物
摘要:系统地研究了酸,醇,酰基酰胺,1,2-二醇,1,2-二胺或氨基醇与1,4-二氮杂双环[2.2.2]辛烷(dabco)催化的炔烃的反应.在一元或二元亲核试剂的反应中,分别以优异的收率形成了一系列不饱和链烯酸酯或杂环.
DOI:10.1016/j.Tet.2006.04.100

专利信息

专利号:US-2021171437-A1
优先权日:2017-07-17
标题 :Peptide nucleic acid (pna) monomers with an orthogonally protected ester moiety and novel intermediates and methods related thereto
发明人：COULL JAMES M; GILDEA BRIAN D
权利人:VERA THERAPEUTICS INC
摘要:The present disclosure pertains to peptide nucleic acid (PNA) monomers and oligomers, as well as methods and compositions useful for the preparation of PNA monomer precursors (e.g. PNA Monomer Esters, Backbone Esters and Backbone Ester Acid Salts, as described below) that can be used to prepare PNA monomers wherein said PNA monomers can be used to prepare said PNA oligomers. In some embodiments, the disclosure features sulfonic acid salts of Backbone Ester compounds, which sulfonic acid salts generally tend to be crystalline and can be obtained in reasonably good yield, often without requiring any chromatographic purification of the reaction product of the Backbone Ester synthesis reaction. This disclosure also pertains to novel methods for the synthesis of said Backbone Ester compounds and novel methods for the formation of the related sulfonic acid salts. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethy-(TCE), 2,2,2-tribromoethyl-(TBE), 2-iodoethyl-groups (2-IE) and 2-bromoethyl-(2-BrE) as the ester group. These particular ester groups can be removed under conditions where both Boc and Fmoc protected amine groups are stable.