📜乙胺盐酸盐置于二氯化二硫体系中,化学反应生成 4,5-二氯-1,2,3-二噻唑氯化物 参考文献:Mayer,Roland,Phosphorus And Sulfur And The Related Elements,1985,Vol. 23,P. 277-296 标题:Mayer,Roland,Phosphorus And Sulfur And The Related Elements,1985,Vol. 23,P. 277-296
专利信息
专利号:US-8772301-B2 优先权日:2009-12-18 标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof 发明人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D 权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC 摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.
专利号:US-11149034-B2 优先权日:2017-07-25 标 题:Derivatives of luciferin and methods for their synthesis 发明人:JARDINE MOEGAMAT ANWAR; RYLANDS MARWAAN 权利人:UNIV CAPE TOWN 摘要:6-Thio derivatives of D-luciferin, also referred to as D-thioluciferins, having the general structure of Formula (I) are provided. Methods for synthesising D-luciferin, its derivatives, and their related 2-cyanobenzothiazole precursors are also provided. These compounds are commercially valuable due to their application in optical imaging, particularly in bioluminescence imaging.
专利号:WO-2019021202-A1 优先权日:2017-07-25 标题:LUCIFERIN DERIVATIVES AND METHODS OF SYNTHESIS
专利号:EP-3658544-B1 优先权日:2017-07-25 标 题 :Derivatives of luciferin and methods for their synthesis
专利号:EP-3658544-A1 优先权日:2017-07-25 标题:Derivatives of luciferin and methods for their synthesis
专利号:US-2020331902-A1 优先权日:2017-07-25 标题 :Derivatives of luciferin and methods for their synthesis