CAS: 60857-08-1; 4A,7B-Dihydroxy-3-(Hydroxymethyl)-1,1,6,8-Tetramethyl-5-Oxo-1,1A,1B,4,4A,5,7A,7B,8,9-Decahydro-9Ah-Cyclopropa[3,4]Benzo[1,2-E]Azulen-9A-Yl Acetate

上下游产品

CAS号1035455-44-7 (3aR,3bS,6aR,9a... | CAS号18325-99-0 4β,9α,20-trihyd...

📜C20-O-Trityl-Prostratin置于甲醇,高氯酸,水,碳酸氢钠体系中,用 甲醇 作为反应溶剂,化学反应 0.33H,以36%的收率获得产物12-脱氧佛波醇-13-乙酸
参考文献:Process To Produce Prostratin And Structural Or Functional Analogs Thereof
标题:Process To Produce Prostratin And Structural Or Functional Analogs Thereof
摘要:这项发明涉及一种将蒽醌型化合物中的一个羟基(在r3C-oh中加粗)转化为氢(在r3C-h中加粗),以获得脱氧蒽醌型化合物或其结构或功能类似物的过程.该过程具有广泛的应用,特别是用于大量生产特定生物活性化合物,以用作药物.具体而言,该过程可用于将富尔酚转化为12-脱氧蒽醌(俯卧的,用于治疗艾滋病的治疗前导物).还公开了新的物质组合.

专利信息

专利号:US-2024132460-A1
优先权日:2021-03-10
标题:Synthesis of tigilanol tiglate and analogs thereof
发明人：WENDER PAUL A; LUU NGUYEN HONG QUANG; GENTRY ZACHARY; NJOO EDWARD; FANELLI DAVID; MCATEER OWEN DENNIS
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Provided are methods for the isolation of phorbol from seed sources and the use of the phorbol for the generation of tigliane tiglate and derivatives thereof.

专利号:US-8759632-B2
优先权日:2005-07-05
标 题 :Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof
发明人：RO DAE-KYUN; NEWMAN KARYN; PARADISE ERIC M; KEASLING JAY D; OUELLET MARIO; EACHUS RACHEL; HO KIMBERLY; HAM TIMOTHY
权利人:RO DAE-KYUN; NEWMAN KARYN; PARADISE ERIC M; KEASLING JAY D; OUELLET MARIO; EACHUS RACHEL; HO KIMBERLY; HAM TIMOTHY; UNIV CALIFORNIA
摘要:The present invention provides isolated nucleic acids comprising nucleotide sequences encoding isoprenoid modifying enzymes, as well as recombinant vectors comprising the nucleic acids. The present invention further provides genetically modified host cells comprising a subject nucleic acid or recombinant vector. The present invention further provides a transgenic plant comprising a subject nucleic acid. The present invention further provides methods of producing an isoprenoid compound, the method generally involving culturing a subject genetically modified host cell under conditions that permit synthesis of an isoprenoid compound modifying enzyme encoded by a subject nucleic acid.

专利号:US-2019106684-A1
优先权日:2016-03-16
标题 :Modified cell
发明人：GRAHAM IAN; KING ANDREW
权利人:UNIV YORK
摘要:The present disclosure relates to nucleic acids that encode enzyme activities involved in the synthesis of lathyranes, intermediates in the synthesis of lathyranes and also compounds derived from lathyranes such as tiglianes, daphnanes and ingenanes; cells transformed with the nucleic acid molecules and vectors comprising the nucleic acid molecules.

专利号:US-2017239212-A1
优先权日:2014-08-11
标 题:Bryostatin analogs and use thereof as antiviral agents
发明人：KECK GARY E; KRAFT MATTHEW B; TRUONG ANH P; SANCHEZ CARINA C; LI WEI; COVEL JONATHAN A; WELCH DENNIE; POUDEL YAM; PETERSEN MARK E
权利人:UNIV UTAH RES FOUND
摘要:Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including the treatment or prevention of viral infection. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in a low number of steps and with a high degree of substitution and specificity.

专利号:WO-2022192521-A1
优先权日:2021-03-10
标 题 :Synthesis of tigilanol tiglate and analogs thereof

专利号:EP-4580642-A2
优先权日:2022-09-01
标 题 :Genetically engineered cd4 t-cells for in situ synthesis of proteins