CAS: 60633-25-2; 2-Bromo-4-Chloro-1-Methoxybenzene

上下游产品

CAS号695-96-5 2-溴-4-氯苯酚 | CAS号77-78-1 硫酸二甲酯 | CAS号74-88-4 碘甲烷 | CAS号623-12-1 4-氯苯甲醚 | CAS号67-68-5 二甲基亚砜 | CAS号3743-23-5 5-氯-2-甲氧基苯酚 | CAS号37908-96-6 3-氯-4-甲氧基苯甲酸 | CAS号3438-16-2 5-氯-2-甲氧基苯甲酸 | CAS号89694-48-4 5-氯-2-甲氧基苯硼酸 | CAS号864755-96-4 methyl 6-(5-chl... | CAS号847348-15-6 4-CHLORO-2-PHEN... | CAS号569688-62-6 2-Bromo-4-chlor... | CAS号569688-63-7 3-溴-5-氯-2-甲氧基苯胺

4-氯苯甲醚置于n-溴代丁二酰亚胺(Nbs)体系中,用 乙腈 作为反应溶剂,化学反应 18.0H,以178 Mg的收率获得产物2-溴-4-氯苯甲醚
参考文献:铁(iii)催化的芳烃氯化反应
标题:铁(iii)催化的芳烃氯化反应
摘要:已经开发了用于活化的芳烃氯化的通用的和区域选择性的方法.该转化过程使用三氟甲磺酸铁(iii)作为强力的路易斯酸来活化n-氯代琥珀酰亚胺和随后的氯化过程,将各种苯甲醚,苯胺,对乙酰苯胺和苯酚衍生物进行氯化.该反应用于一系列目标化合物的后期单氯化和二氯化反应,这些目标化合物例如是天然产物硝苯芬净,抗菌剂氯氧lenol和除草剂氯己腈.一锅,串联,铁催化的二卤化过程的发展证明了这种转变的简便性,可以高度区域选择性地形成不同的碳-卤键.通过合成天然产物和药物相关靶标,建立了所得二卤代芳基化合物作为结构单元的合成效用.
DOI:10.1021/acs.Joc.7B01225

专利信息

专利号:US-2006089405-A1
优先权日:2004-10-21
标 题 :Asymmetric synthesis of dihydrobenzofuran derivatives
发明人：ZHOU DAHUI; STACK GARY P; GONTCHAROV ALEXANDER V
权利人:WYETH CORP
摘要:This invention concerns a process for the preparation of benzofuran derivatives. In some aspects, these compounds are of formula I: n n nwherein each of R 1 , R 2 , R 3 , and R 4 is as defined herein.

专利号:US-9265773-B2
优先权日:2011-09-08
标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI; MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:WO-2009011653-A1
优先权日:2007-07-17
标题:A process for the preparation of intermediates and their us in the synthesis of spiropiperidine compounds

专利号:AU-2005299757-A1
优先权日:2004-10-21
标 题:Asymmetric synthesis of dihydrobenzofuran derivatives

专利号:CA-2584775-A1
优先权日:2004-10-21
标题:Asymmetric synthesis of dihydrobenzofuran derivatives

专利号:WO-2006047288-A2
优先权日:2004-10-21
标 题:Asymmetric synthesis of dihydrobenzofuran derivatives