CAS: 60-40-2; N,2,2,3-Tetramethylbicyclo[2.2.1]Heptan-3-Amine

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N-去甲基-N-甲酰基美卡拉明 2-Formylamino-Isocamphan 86351-88-4

合成工艺路线路线简述

    📜N-去甲基-N-甲酰基美卡拉明,Sodium;Tetratritioboranuide,三氟化硼,乙醚,四氢呋喃,盐酸 反应生成 美卡拉明
    参考文献:Filer,Crist N.;Nugent,Richard P.;Shelton,Emma J.,Trans. Amer. Nucl. Soc.,60,(1989) C. 36-38
    标题:Filer,Crist N.;Nugent,Richard P.;Shelton,Emma J.,Trans. Amer. Nucl. Soc.,60,(1989) C. 36-38

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    专利信息


    专利号:US-9353057-B2
    优先权日:2003-12-30
    标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    发明人:GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
    权利人:XENOPORT INC
    摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:US-12365760-B2
    优先权日:2019-05-13
    标题 :Process for the synthesis of polycarbonates from cyclic monothiocarbonates
    发明人:RUDOLF PETER; THIEL INDRE; WURM THOMAS MAXIMILIAN
    权利人:BASF SE
    摘要:A process can be used for the synthesis of compounds containing at least one non-cyclic carbonate group, wherein a compound A) containing at least one five-membered cyclic monothiocarbonate group is reacted with at least one hydroxy group of a compound B) or of compound A) itself.

    专利号:US-9315483-B2
    优先权日:2007-09-13
    标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
    发明人:JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
    权利人:CONCERT PHARMACEUTICALS INC
    摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

    专利号:US-2015158809-A9
    优先权日:2013-02-26
    标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
    发明人:WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
    权利人:XENOPORT INC
    摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.

    专利号:US-9556123-B2
    优先权日:2004-07-19
    标题:Synthesis of triethylenetetramines
    发明人:JONAS MARCO; VAULONT IRENE; SOI ANTONIO; SCHMIDT GUNTHER
    权利人:PHILERA NEW ZEALAND LTD
    摘要:Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.

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    合成参考文献


    参考文献:10.1097/fjc.0b013e31822b7204
    摘要:Calvillo L, Vanoli E, Andreoli E, Besana A, Omodeo E, Gnecchi M, Zerbi P, Vago G, Busca G, Schwartz PJ. Vagal Stimulation, Through its Nicotinic Action, Limits Infarct Size and the Inflammatory Response to Myocardial Ischemia and Reperfusion. Journal of Cardiovascular Pharmacology. 2011 Nov;58(5):500–7. doi: 10.1097/fjc.0b013e31822b7204.
    参考文献:10.1093/bja/aer202
    摘要:Kox M, Pompe JC, Peters E, Vaneker M, van der Laak JW, van der Hoeven JG, Scheffer GJ, Hoedemaekers CW, Pickkers P. α7 Nicotinic acetylcholine receptor agonist GTS-21 attenuates ventilator-induced tumour necrosis factor-α production and lung injury. British Journal of Anaesthesia. 2011 Oct;107(4):559–66. doi: 10.1093/bja/aer202.
    参考文献:10.1039/c1pp05131h
    摘要:Lamore SD, Wondrak GT. Autophagic-lysosomal dysregulation downstream of cathepsin B inactivation in human skin fibroblasts exposed to UVA. Photochemical & Photobiological Sciences. 2012 Nov 01;11(1):163–72. doi: 10.1039/c1pp05131h.
    参考文献:10.1139/o11-032
    摘要:Yu M, Liu Q, Sun J, Yi K, Wu L, Tan X. Nicotine improves the functional activity of late endothelial progenitor cells via nicotinic acetylcholine receptors. Biochem Cell Biol. 2011 Aug;89(4):405–10. doi: 10.1139/o11-032.
    参考文献:10.1007/s10911-011-9223-3
    摘要:Debnath J. The Multifaceted Roles of Autophagy in Tumors—Implications for Breast Cancer. Journal of Mammary Gland Biology and Neoplasia. 2011 Jul 21;16(3):173. doi: 10.1007/s10911-011-9223-3.
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