CAS: 553-27-5; N,N-Bis(2-Chloroethyl)Aniline

该化合物是一种氯乙酸芳香矿,可应用于有机合成和制药中间体,该化合物有两种活性2-氯乙基组,结合氮原子,能够用作制备氮芥子气和其他专门衍生物的碱基剂,其结构允许选择性地发挥功能,使其在发展有针对性的化学改造过程中具有价值.该产品一般在受控条件下处理,原因是其反应性和潜在毒性.在需要精确的烷基化的情况下,通常用于合成生物活性分子的研究环境.适当的储存和处理对于维持稳定至关重要.

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合成工艺路线路线简述

    📜N,N-二乙基苯胺置于氯化亚砜体系中,用 甲苯 作为反应溶剂,化学反应 1.0H,反应生成 N,N-双(2-氯乙基)苯胺
    参考文献:Ep1679069
    标题:Ep1679069

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    专利信息


    专利号:US-2025228878-A1
    优先权日:2021-10-14
    标题:Method for the synthesis of evoc probes
    发明人:ALLSWORTH MAX; LABUSCHAGNE CHRISTIAAN
    权利人:OWLSTONE MED LTD
    摘要:A process for the synthesis of a glycoside, comprising the step of;n performing hydrolysis of a methyl ester glycoside in the presence of a base in water, to form a glycoside,n nwherein the propensity to reform the methyl ester glycoside is reduced. The invention also extends to methods for the detection or prognosis of cancer using a glycoside obtained by said process

    专利号:US-6313297-B1
    优先权日:1998-01-17
    标题:Base-catalyzed synthesis of 1-aryl-4-(aryl ethyl)piperazines from aromatic olefins and 1-arylpiperazines
    发明人:HERWIG JUERGEN; BELLER MATTHIAS; BREINDL CLAUDIA
    权利人:AVENTIS RES & TECHNOLOGIES; GMBH & CO KG
    摘要:A process for preparing a 1-aryl-4-(arylethyl)piperazine of the formula (I)by reacting a 1-arylpiperazine of the formula (II)with an aromatic olefin of the formula (III)in an inert solvent in the presence of at least one basic catalyst, where in the formulae (I) to (III)Ar and Ar' independently of one another are an aryl radical, selected from the group of the fused and unfused C6-C22-aromatics and the fused or unfused C5-C22-heteroaromatics which have at least one nitrogen, oxygen or sulfur atom in the ring; andR1 and R2 independently of one another are a hydrogen atom, a C1-C8-alkyl radical or an aryl radical Ar.

    专利号:US-6562844-B2
    优先权日:1998-01-23
    标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:EP-4416163-A1
    优先权日:2021-10-14
    标题:Method for the synthesis of evoc probes

    专利号:US-7002020-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:WO-2023062386-A1
    优先权日:2021-10-14
    标题 :Method for the synthesis of evoc probes

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Chen CH, Hu TH, Huang TC, Chen YL, Chen YR, Cheng CC, Chen CT. Delineation of G-Quadruplex Alkylation Sites Mediated by 3,6-Bis(1-methyl-4-vinylpyridinium iodide)carbazole-Aniline Mustard Conjugates. Chemistry. 2015 Nov 23;21(48):17379-90. doi: 10.1002/chem.201502595. Epub 2015 Oct 13. doi: 10.1074/jbc.M111.278390. Epub 2011 Aug 10.
    3: Benckhuysen C, Ter Hart HG, Van Dijk PJ. Enhanced cytostatic effectiveness of aniline mustard against 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors during regression in response to ovariectomy. Cancer Treat Rep. 1981 Jul-Aug;65(7-8):567-74. Review. doi: 10.1016/j.steroids.2016.07.009. Epub 2016 Jul 26. doi: 10.1016/j.bmc.2008.04.024. Epub 2008 Apr 15.

    合成参考文献


    参考文献:10.1007/s10549-005-9083-x
    摘要:Trafalis DT, Geromichalos GD, Koukoulitsa C, Papageorgiou A, Karamanakos P, Camoutsis C. Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer. Breast Cancer Res Treat. 2006 May;97(1):17–31. doi: 10.1007/s10549-005-9083-x.
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