CAS: 5498-31-7; 1-Bromo-3-Hydroxynaphthalene

相似化合物

116632-05-4 2648221-50-3 7385-87-7

上下游产品

4-bromo-1-diazonio-naphthalen-2-olate 4-bromonaphthalene-2-amine 4-bromo-2-nitro-1-naphthylamine 4-bromo-2-nitronaphthalene b]furan5-bromo-1,2-diphenyl-naphtho[2,1-b]furan 3-hydroxynaphthalenecarboxaldehyde -naphthopyran6-bromo-3,3-diphenyl-3H-naphtho2,1-bpyran diphenyl-phosphinic acid 4-bromo-naphthalen-2-yl ester

📜硝基萘置于三乙基硅烷,Sodium Tetrahydroborate,溴,溶剂黄146,丙酸,Palladium Dichloride,Sodium Nitrite体系中,用 乙醇,溶剂黄146 作为反应溶剂,化学反应 0.59H,反应生成 1-溴-3-羟基萘
参考文献:Discovery Of Novel Naphthylphenylketone And Naphthylphenylamine Derivatives As Cell Division Cycle 25B (Cdc25B) Phosphatase Inhibitors: Design,Synthesis,Inhibition Mechanism,And In Vitro Efficacy Against Melanoma Cell Lines
标题:Discovery Of Novel Naphthylphenylketone And Naphthylphenylamine Derivatives As Cell Division Cycle 25B (Cdc25B) Phosphatase Inhibitors: Design,Synthesis,Inhibition Mechanism,And In Vitro Efficacy Against Melanoma Cell Lines
摘要:Cdc25 Phosphatases Play A Critical Role In The Regulation Of The Cell Cycle And Thus Represent Attractive Cancer Therapeutic Targets. We Previously Discovered The 4-(2-Carboxybenzoyl)Phthalic Acid (Nsc28620) As A New Cdc25 Inhibitor Endowed With Promising Anticancer Activity In Breast,Prostate,And Leukemia Cells. Herein,We Report A Structure-Based Optimization Of Nsc28620,Leading To The Identification Of A Series Of Novel Naphthylphenylketone And Naphthylphenylamine Derivatives As Cdc25B Inhibitors. Compounds 7J,7I,6E,7F,And 3 Showed Higher Inhibitory Activity Than The Initial Lead,With Ki Values In The Low Micromolar Range. Kinetic Analysis,Intrinsic Fluorescence Studies,And Induced Fit Docking Simulations Provided A Mechanistic Understanding Of The Activity Of These Derivatives. All Compounds Were Tested In The Highly Aggressive Human Melanoma Cell Lines A2058 And A375. Compound 4A Potently Inhibited Cell Proliferation And Colony Formation,Causing An Increase Of The G2/m Phase And A Reduction Of The G0/g1 Phase Of The Cell Cycle In Both Cell Lines.
DOI:10.1021/acs.Jmedchem.9B00632

专利信息

专利号:WO-2025118034-A1
优先权日:2023-12-06
标题 :Compounds active at the serotonergic 5-ht2a receptor
发明人：JORGENSON WILLIAM; TAN JINLONG; WHISH LACHLAN; BANISTER SAMUEL
权利人:Psylo Pty Ltd
摘要:The present disclosure relates to compounds of formula (I), their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.