CAS: 54848-30-5; (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5R,6R)-5-Hydroxy-2-(((4S,6Ar,6Bs,8As,8Br,9S,10R,11As,12As,12Bs)-10-Hydroxy-6A,8A,9-Trimethyl-10-((R)-3-Methyl-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Butyl)-3,4,5,6,6A,6B,7,8,8A,8B,9,10,11A,12,12A,12B-Hexadecahydro-1H-Naphtho[2',1':4,5]Indeno[2,1-B]Furan-4-yl)Oxy)-6-(Hydroxymethyl)-4-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-3-yl)Oxy)-6-Methyltetrahydro-2H-Pyran-3,4,5-Triol

该化合物是属于抗生素类的化学化合物,来自自然来源,具有抗菌特性,有助于治疗各种细菌感染,其特点是其特定的分子结构,包括有助于其生物活动的功能组别,其特点是其特定分子结构,包括有助于其生物活动的各种功能组别,普罗托格拉西林因其对某些细菌菌株的功效而闻名,其行动机制通常包括抑制细菌细胞壁合成,从而防止细菌的生长和复制.此外,它可能拥有增强细菌稳定性和生物利用率的特性.与许多抗生素一样,使用丙加西林应该以感应测试为指导,以确保抗生素的功效和尽量减少抗药性发展的风险.安全和副作用也是其应用中的重要考虑因素,需要在治疗过程中进行仔细监测.

• 英文名称(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5R,6R)-5-Hydroxy-2-(((4S,6Ar,6Bs,8As,8Br,9S,10R,11As,12As,12Bs)-10-Hydroxy-6A,8A,9-Trimethyl-10-((R)-3-Methyl-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Butyl)-3,4,5,6,6A,6B,7,8,8A,8B,9,10,11A,12,12A,12B-Hexadecahydro-1H-Naphtho[2',1':4,5]Indeno[2,1-B]Furan-4-yl)Oxy)-6-(Hydroxymethyl)-4-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-3-yl)Oxy)-6-Methyltetrahydro-2H-Pyran-3,4,5-Triol
• 中文名称原纤细薯蓣皂苷
• IUPAC名称(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5R,6R)-5-hydroxy-2-(((4S,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-10-hydroxy-6a,8a,9-trimethyl-10-((R)-3-methyl-4-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)butyl)-3,4,5,6,6a,6b,7,8,8a,8b,9,10,11a,12,12a,12b-hexadecahydro-1H-naphtho[2',1':4,5]indeno[2,1-b]furan-4-yl)oxy)-6-(hydroxymethyl)-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
• 其它别名Protogracillin(P); Protogracillin; Protogracillin 98.0% By Hplc; Lilioglycosider; (3β,22α,25R)-26-(β-D-Glucopyranosyloxy)-22-Hydroxyfurost-5-En-3-Yl O-6-Deoxy-α-L-Mannopyranosyl-(1→2)-O-[β-D-Glucopyranosyl-(1→3)]-β-D-Glucopyranoside; Protogracillin, , From Dioscorea Opposita Thunb.; B-D-Glucopyranoside, (3B,22A,25R)-26-(B-D-Glucopyranosyloxy)-22-Hydroxyfurost-5-En-3-Yl O-6-Deoxy-A-L-Mannopyranosyl-(12)-O-[b-D-Glucopyranosyl-(13)]-; β-D-Glucopyranoside, (3β,22α,25R)-26-(β-D-Glucopyranosyloxy)-22-Hydroxyfurost-5-En-3-Yl O-6-Deoxy-α-L-Mannopyranosyl-(1→2)-O-[β-D-Glucopyranosyl-(1→3)]-
• CAS编号54848-30-5
• MFCD编号:MFCD09038733
• 分子式:C51H84O23分子量:1065.21
• 产品CID: 2508242
• 产品分类生物化工 → 提取物

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: GMCGZPQYTRHQRU-DKWQWWTLSA-N
• InChI=1S/C51H84O23/c1-20(19-66-45-40(62)38(60)34(56)29(16-52)69-45)8-13-51(65)21(2)32-28(74-51)15-27-25-7-6-23-14-24(9-11-49(23,4)26(25)10-12-50(27,32)5)68-48-44(73-46-41
• 计算化学: 氢键受体数23.0氢键供体数14.0可旋转键数15.0

物理性质

• 密度1.5±0.1 g/cm3
• pKa:12.78±0.70(预测)
• PSA:366.29
• LogP:0.81
• 折射率1.640
• 溶解性DMF: 30 mg/mL; DMSO: 30 mg/mL
• 外观形态类白色至淡黄色固体
• 储存条件-20°C，密闭，干燥环境
• 产品应用该化合物是一种最初与T. TERRESTRIS隔离的类固醇沙邦因,对K562细胞具有细胞毒性. 血清沙邦宁是植物对生物和非生物压力作出反应所必不可少的一种重要的植物特定代谢物.

MSDS等安全信息

• 警示词Warning
• 危险描述H302-H315-H319-
• 防范说明P264-P270-P280-P301+P312+P330-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P501-
• 安全声明24/25

上下游产品

Methyl Protogracillin 54522-53-1

合成工艺路线路线简述

📜Methyl Protogracillin 以 水,丙酮 作为反应溶剂,化学反应 24.0H,以394 Mg的收率获得产物原纤细薯蓣皂甙
参考文献:A Furostanol Glycoside From Rhizomes Of Dioscorea Collettii Var. Hypoglauca
标题:A Furostanol Glycoside From Rhizomes Of Dioscorea Collettii Var. Hypoglauca
摘要:
DOI:10.1016/s0031-9422(96)00750-9

海关参考信息

• 2901210000-乙烯
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  2905122000-异丙醇
  2905310000-1,2-乙二醇
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

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主要参考文献

1. Tomova, M., Gyulemetova, R., Zarkova, S., et al. Steroidal saponins from Tribulus terrestris L. with a stimulating action on the sexual functions. 1st Int. Conf. Chem. Biotechnol. Biol. Act. Nat. Prod. 3(1), 298-302 (1982). 2. Hu, K., Dong, A.-J., Yao, X.-S., et al. Antineoplastic steroidal saponins from rhizomes of DIoscorea collettii var. Hypoglauca. Stud. Plant Sci. 6, 220-229 (1999). 3. Li Y, Yang H, Li Z, Li S, Li J. Advances in the Biosynthesis and Molecular Evolution of Steroidal Saponins in Plants. Int J Mol Sci. 2023 Jan 30;24(3):2620. doi: 10.3390/ijms24032620.

合成参考文献

参考文献:10.1248/cpb.22.2164
摘要:KAWASAKI T, KOMORI T, MIYAHARA K, NOHARA T, HOSOKAWA I, MIHASHI K. Furostanol bisglycosides corresponding to dioscin and gracillin. Chem. Pharm. Bull. 1974;22(9):2164–75. doi: 10.1248/cpb.22.2164.
参考文献:10.1016/s0928-3420(99)80031-7
摘要:Cui T, Zheng Q, Mi L, Zhang L, Tu Z. Screening for molluscicidal activity in medicinal plant. 1999. In: Studies in Plant Science.
参考文献:10.1016/s0031-9422(96)00750-9
摘要:Ke Hu, Ai-Jun Dong, Xin-Sheng Yao, Kobayashi H, Iwasaki S. A furostanol glycoside from rhizomes of Dioscorea collettii var. hypoglauca. Phytochemistry. 1997 Apr;44(7):1339–42. doi: 10.1016/s0031-9422(96)00750-9.

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